scholarly journals LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins

2007 ◽  
Vol 35 (19) ◽  
pp. 6663-6671 ◽  
Author(s):  
Aman Husbands ◽  
Elizabeth M. Bell ◽  
Bin Shuai ◽  
Harley M.S. Smith ◽  
Patricia S. Springer
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
New Family ◽  
Lateral Organ ◽  
Bhlh Proteins ◽  
Organ Boundaries

scholarly journals Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C

1999 ◽  
Vol 19 (4) ◽  
pp. 2853-2862 ◽  
Author(s):  
Jeanne Wilson-Rawls ◽  
Jeffery D. Molkentin ◽  
Brian L. Black ◽  
Eric N. Olson
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
Notch Signaling Pathway ◽  
Mads Box ◽  
Dna Binding Domains ◽  
Muscle Gene Expression ◽  
Binding Domains ◽  
Myocyte Enhancer Factor ◽  
Bhlh Proteins ◽  
Enhancer Factor

ABSTRACT Skeletal muscle gene expression is dependent on combinatorial associations between members of the MyoD family of basic helix-loop-helix (bHLH) transcription factors and the myocyte enhancer factor 2 (MEF2) family of MADS-box transcription factors. The transmembrane receptor Notch interferes with the muscle-inducing activity of myogenic bHLH proteins, and it has been suggested that this inhibitory activity of Notch is directed at an essential cofactor that recognizes the DNA binding domains of the myogenic bHLH proteins. Given that MEF2 proteins interact with the DNA binding domains of myogenic bHLH factors to cooperatively regulate myogenesis, we investigated whether members of the MEF2 family might serve as targets for the inhibitory effects of Notch on myogenesis. We show that a constitutively activated form of Notch specifically blocks DNA binding by MEF2C, as well as its ability to cooperate with MyoD and myogenin to activate myogenesis. Responsiveness to Notch requires a 12-amino-acid region of MEF2C immediately adjacent to the DNA binding domain that is unique to this MEF2 isoform. Two-hybrid assays and coimmunoprecipitations show that this region of MEF2C interacts directly with the ankyrin repeat region of Notch. These findings reveal a novel mechanism for Notch-mediated inhibition of myogenesis and demonstrate that the Notch signaling pathway can discriminate between different members of the MEF2 family.

scholarly journals Lateral organ boundaries domain transcription factors

2012 ◽  
Vol 7 (12) ◽  
pp. 1702-1704 ◽  
Author(s):  
Louise F. Thatcher ◽  
Kemal Kazan ◽  
John M. Manners
Keyword(s):  
Transcription Factors ◽  
Lateral Organ ◽  
Organ Boundaries

scholarly journals A Novel DNA-Binding Motif, Hallmark of a New Family of Plant Transcription Factors

2005 ◽  
Vol 137 (2) ◽  
pp. 602-606 ◽  
Author(s):  
José L. Carrasco ◽  
Gema Ancillo ◽  
María José Castelló ◽  
Pablo Vera
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
Binding Motif ◽  
New Family

scholarly journals Genome-Wide Identification of LATERAL ORGAN BOUNDARIES DOMAIN (LBD) Transcription Factors and Screening of Salt Stress Candidates of Rosa rugosa Thunb

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 992
Author(s):  
Jianwen Wang ◽  
Weijie Zhang ◽  
Yufei Cheng ◽  
Liguo Feng
Keyword(s):  
Transcription Factors ◽  
Salt Stress ◽  
Abiotic Stress ◽  
Gene Family ◽  
Expression Patterns ◽  
Wild Plant ◽  
Stress Signaling ◽  
Rosa Rugosa ◽  
Lateral Organ ◽  
Organ Boundaries

LATERAL ORGAN BOUNDARIES DOMAIN (LBD) transcription factors are regulators of lateral organ morphogenesis, boundary establishment, and secondary metabolism in plants. The responsive role of LBD gene family in plant abiotic stress is emerging, whereas its salt stress responsive mechanism in Rosa spp. is still unclear. The wild plant of Rosa rugosa Thunb., which exhibits strong salt tolerance to stress, is an ideal material to explore the salt-responsive LBD genes. In our study, we identified 41 RrLBD genes based on the R. rugosa genome. According to phylogenetic analysis, all RrLBD genes were categorized into Classes I and II with conserved domains and motifs. The cis-acting element prediction revealed that the promoter regions of most RrLBD genes contain defense and stress responsiveness and plant hormone response elements. Gene expression patterns under salt stress indicated that RrLBD12c, RrLBD25, RrLBD39, and RrLBD40 may be potential regulators of salt stress signaling. Our analysis provides useful information on the evolution and development of RrLBD gene family and indicates that the candidate RrLBD genes are involved in salt stress signaling, laying a foundation for the exploration of the mechanism of LBD genes in regulating abiotic stress.

scholarly journals LATERAL ORGAN BOUNDARIES DOMAIN transcription factors direct callus formation in Arabidopsis regeneration

Cell Research ◽  
2012 ◽  
Vol 22 (7) ◽  
pp. 1169-1180 ◽  
Author(s):  
Mingzhu Fan ◽  
Chongyi Xu ◽  
Ke Xu ◽  
Yuxin Hu
Keyword(s):  
Transcription Factors ◽  
Callus Formation ◽  
Lateral Organ ◽  
Organ Boundaries

The Banana MaLBD (LATERAL ORGAN BOUNDARIES DOMAIN) Transcription Factors Regulate EXPANSIN Expression and Are Involved in Fruit Ripening

2014 ◽  
Vol 32 (6) ◽  
pp. 1103-1113 ◽  
Author(s):  
Liang-jie Ba ◽  
Wei Shan ◽  
Jian-fei Kuang ◽  
Bi-hong Feng ◽  
Yun-yi Xiao ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Fruit Ripening ◽  
Lateral Organ ◽  
Organ Boundaries

DNA-binding profiles of mammalian transcription factors

2012 ◽  
Vol 34 (8) ◽  
pp. 950-968
Author(s):  
Guang-Ming GU ◽  
Jin-Ke WANG
Keyword(s):  
Transcription Factors ◽  
Dna Binding
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