A new family of plant transcription factors displays a novel ssDNA-binding surface

2002 ◽  
Vol 9 (7) ◽  
pp. 512-517 ◽  
Author(s):  
Darrell Desveaux ◽  
Julie Allard ◽  
Normand Brisson ◽  
Jurgen Sygusch
Keyword(s):  
Transcription Factors ◽  
Ssdna Binding ◽  
New Family ◽  
Binding Surface

Single-Stranded DNA-Binding Protein Complex from Helicobacter pylori Suggests an ssDNA-Binding Surface

2009 ◽  
Vol 388 (3) ◽  
pp. 508-519 ◽  
Author(s):  
Kun-Wei Chan ◽  
Yi-Juan Lee ◽  
Chia-Hung Wang ◽  
Haimei Huang ◽  
Yuh-Ju Sun
Keyword(s):  
Helicobacter Pylori ◽  
Dna Binding ◽  
Protein Complex ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Single Stranded Dna ◽  
Ssdna Binding ◽  
Binding Surface

scholarly journals LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins

2007 ◽  
Vol 35 (19) ◽  
pp. 6663-6671 ◽  
Author(s):  
Aman Husbands ◽  
Elizabeth M. Bell ◽  
Bin Shuai ◽  
Harley M.S. Smith ◽  
Patricia S. Springer
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
New Family ◽  
Lateral Organ ◽  
Bhlh Proteins ◽  
Organ Boundaries

scholarly journals A new family of transcription factors

Development ◽  
2008 ◽  
Vol 135 (18) ◽  
pp. 3093-3101 ◽  
Author(s):  
Y. Yamada ◽  
H. Y. Wang ◽  
M. Fukuzawa ◽  
G. J. Barton ◽  
J. G. Williams
Keyword(s):  
Transcription Factors ◽  
New Family

scholarly journals Biophysical investigation of the dual binding surfaces of human transcription factors FOXO4 and p53

2021 ◽  
Author(s):  
Jinwoo Kim ◽  
Dabin Ahn ◽  
Chin-Ju Park
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
Cellular Senescence ◽  
Structural Information ◽  
Titration Calorimetry ◽  
Transactivation Domain ◽  
Forkhead Box ◽  
Binding Surface ◽  
Forkhead Domain ◽  
Oncogenic Stress

AbstractCellular senescence is protective against external oncogenic stress, but its accumulation causes aging-related diseases. Forkhead box O4 (FOXO4) and p53 are human transcription factors known to promote senescence by interacting in the promyelocytic leukemia bodies. Inhibiting their binding is a strategy for inducing apoptosis of senescent cells, but the binding surfaces that mediate the interaction of FOXO4 and p53 remain elusive. Here, we investigated two binding sites involved in the interaction between FOXO4 and p53 by using NMR spectroscopy. NMR chemical shift perturbation analysis showed that the binding between FOXO4’s forkhead domain (FHD) and p53’s transactivation domain (TAD), and between FOXO4’s C-terminal transactivation domain (CR3) and p53’s DNA binding domain (DBD), mediate the FOXO4-p53 interaction. Also, we showed that the CR3-binding surface of FOXO4 FHD interacts with p53 TAD2, and four residues of FOXO4 CR3 interact with the DNA-binding surface of p53 DBD. Further isothermal titration calorimetry experiments showed that the FOXO4 FHD-p53 TAD interaction takes precedence with high affinity and that the FOXO4 CR3-p53 DBD interaction follows. This work provides structural information at the molecular level that is key to understanding the interplay of two proteins responsible for cellular senescence.

scholarly journals A Novel DNA-Binding Motif, Hallmark of a New Family of Plant Transcription Factors

2005 ◽  
Vol 137 (2) ◽  
pp. 602-606 ◽  
Author(s):  
José L. Carrasco ◽  
Gema Ancillo ◽  
María José Castelló ◽  
Pablo Vera
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
Binding Motif ◽  
New Family

scholarly journals Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells

Blood ◽  
1993 ◽  
Vol 81 (11) ◽  
pp. 2854-2859 ◽  
Author(s):  
R Hromas ◽  
J Moore ◽  
T Johnston ◽  
C Socha ◽  
M Klemsz
Keyword(s):  
Polymerase Chain Reaction ◽  
Transcription Factors ◽  
Pcr Amplification ◽  
Amino Acid Sequences ◽  
Myelogenous Leukemia ◽  
Transcriptional Activators ◽  
Chain Reaction ◽  
New Family ◽  
Polymerase Chain ◽  
Forkhead Gene

Abstract The forkhead gene (FKH) regulates morphogenesis in Drosophila. It is the prototype of a new family of transcriptional activators. Partially degenerate oligonucleotides to two conserved amino acid sequences of this family were used to prime a polymerase chain reaction (PCR) amplification of HEL cell cDNA. Two unique clones, designated H3 and H8, were isolated that contained homologies to FKH. A third novel clone, 5–3, was isolated by low stringency screening of a chronic myelogenous leukemia cDNA library using H8 as a probe. H3 and 5–3 are preferentially expressed in restricted hematopoietic lineages, while the expression of H8 was ubiquitous. Southern analysis showed that FKH 5–3 is conserved through yeast, which is rare among tissue-specific transcription factors. The H3 and 5–3 clones provide evidence that FKH family members are present in a tissue-restricted manner in humans.

scholarly journals Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells

Blood ◽  
1993 ◽  
Vol 81 (11) ◽  
pp. 2854-2859 ◽  
Author(s):  
R Hromas ◽  
J Moore ◽  
T Johnston ◽  
C Socha ◽  
M Klemsz
Keyword(s):  
Polymerase Chain Reaction ◽  
Transcription Factors ◽  
Pcr Amplification ◽  
Amino Acid Sequences ◽  
Myelogenous Leukemia ◽  
Transcriptional Activators ◽  
Chain Reaction ◽  
New Family ◽  
Polymerase Chain ◽  
Forkhead Gene

The forkhead gene (FKH) regulates morphogenesis in Drosophila. It is the prototype of a new family of transcriptional activators. Partially degenerate oligonucleotides to two conserved amino acid sequences of this family were used to prime a polymerase chain reaction (PCR) amplification of HEL cell cDNA. Two unique clones, designated H3 and H8, were isolated that contained homologies to FKH. A third novel clone, 5–3, was isolated by low stringency screening of a chronic myelogenous leukemia cDNA library using H8 as a probe. H3 and 5–3 are preferentially expressed in restricted hematopoietic lineages, while the expression of H8 was ubiquitous. Southern analysis showed that FKH 5–3 is conserved through yeast, which is rare among tissue-specific transcription factors. The H3 and 5–3 clones provide evidence that FKH family members are present in a tissue-restricted manner in humans.

HIPK2: a multitalented partner for transcription factors in DNA damage response and developmentThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

2007 ◽  
Vol 85 (4) ◽  
pp. 411-418 ◽  
Author(s):  
Cinzia Rinaldo ◽  
Andrea Prodosmo ◽  
Francesca Siepi ◽  
Silvia Soddu
Keyword(s):  
Transcription Factors ◽  
Gene Transcription ◽  
Review Process ◽  
Peer Review Process ◽  
Post Translational Modification ◽  
Interacting Protein ◽  
Cellular Processes ◽  
New Family ◽  
Damage Response ◽  
Selection Of

Protein phosphorylation is a widely diffuse and versatile post-translational modification that controls many cellular processes, from signal transduction to gene transcription. The homeodomain-interacting protein kinases (HIPKs) belong to a new family of serine–threonine kinases first identified as corepressors for homeodomain transcription factors. Different screenings for the identification of new partners of transcription factors have indicated that HIPK2, the best characterized member of the HIPK family, is a multitalented coregulator of an increasing number of transcription factors and cofactors. The aim of this review is to describe the different mechanisms through which HIPK2 regulates gene transcription.

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