Dermal delivery of desmopressin acetate using colloidal carrier systems

2005 ◽  
Vol 57 (4) ◽  
pp. 423-427 ◽  
Author(s):  
Melkamu Getie ◽  
Johannes Wohlrab ◽  
Reinhard H. H. Neubert
Keyword(s):  
Dermal Delivery ◽  
Colloidal Carrier ◽  
Carrier Systems

scholarly journals Case studies of enhanced pharmacodynamic activity of poorly oral bioavailable drugs via solid lipid nanoparticles

2021 ◽  
Vol 11 (2) ◽  
pp. 204-208
Author(s):  
D Raju
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Absorption ◽  
Lipid Nanoparticles ◽  
Lymphatic Transport ◽  
Therapeutic Effectiveness ◽  
Therapeutic Activity ◽  
Solid Lipid ◽  
Current Review ◽  
Colloidal Carrier ◽  
Carrier Systems

Solid lipid nanoparticles (SLNs) considered as an alternative vehicle for the enhanced oral absorption of drugs, and also to enhance therapeutic effectiveness after oral administration. Pharmacodynamic activity of drug is mainly describes the pharmacological and therapeutic activity of drug to the biological system. Lipid nanoparticles especially SLNs made of physiological inert lipid molecules and helps the lymphatic transport. Numerous literatures is available on the effect of SLNs and other colloidal carrier systems on the pharmacokinetic activity of poorly bioavailable drugs, to improve their oral absorption and also respective mechanisms for the improved oral bioavailability. However, very few literatures is reported on the pharmacodynamic activity and the effect of dose on the pharmacodynamic activity. Therefore, the current review is mainly dealing with the effect of SLNs on the pharmacodynamic activity discussed.   Keywords: Oral absorption, solid lipid nanoparticles, lymphatic transport, pharmacokinetics, pharmacodynamics.

Lipid Nanoparticles and Active Natural Compounds: A Perfect Combination for Pharmaceutical Applications

2019 ◽  
Vol 26 (24) ◽  
pp. 4681-4696 ◽  
Author(s):  
Carmelo Puglia ◽  
Rosario Pignatello ◽  
Virginia Fuochi ◽  
Pio Maria Furneri ◽  
Maria Rosaria Lauro ◽  
...  
Keyword(s):  
Water Solubility ◽  
Chemical Nature ◽  
Natural Compounds ◽  
Lipid Nanoparticles ◽  
Pharmaceutical Applications ◽  
Therapeutic Properties ◽  
Colloidal Carrier ◽  
Carrier Systems ◽  
Active Natural ◽  
Significant Health

Phytochemicals represent an important class of bioactive compounds characterized by significant health benefits. Notwithstanding these important features, their potential therapeutic properties suffer from poor water solubility and membrane permeability limiting their approach to nutraceutical and pharmaceutical applications. Lipid nanoparticles are well known carrier systems endowed with high biodegradation and an extraordinary biocompatible chemical nature, successfully used as platform for advanced delivery of many active compounds, including the oral, topical and systemic routes. This article is aimed at reviewing the last ten years of studies about the application of lipid nanoparticles in active natural compounds reporting examples and advantages of these colloidal carrier systems.

Colloidal Carrier Systems for Transcutaneous Immunization

2011 ◽  
Vol 12 (4) ◽  
pp. 579-597 ◽  
Author(s):  
Prem N. Gupta ◽  
Suresh P. Vyas
Keyword(s):  
Transcutaneous Immunization ◽  
Colloidal Carrier ◽  
Carrier Systems

scholarly journals Nanoliposomes and Tocosomes as Multifunctional Nanocarriers for the Encapsulation of Nutraceutical and Dietary Molecules

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 638 ◽  
Author(s):  
Ali Zarrabi ◽  
Mandana Alipoor Amro Abadi ◽  
Sepideh Khorasani ◽  
M.-Reza Mohammadabadi ◽  
Aniseh Jamshidi ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Formation Mechanisms ◽  
Bioactive Materials ◽  
Health Promoting ◽  
Nanoscale Object ◽  
Multifunctional Nanocarriers ◽  
Spherical Vesicles ◽  
Colloidal Carrier ◽  
Carrier Systems ◽  
Hydrophobic Material

Nanoscale lipid bilayers, or nanoliposomes, are generally spherical vesicles formed by the dispersion of phospholipid molecules in a water-based medium by energy input. The other nanoscale object discussed in this entry, i.e., tocosome, is a recently introduced bioactive carrier made mainly from tocopheryl phosphates. Due to their bi-compartmental structure, which consists of lipidic and aqueous compartments, these nanocarriers are capable of carrying hydrophilic and hydrophobic material separately or simultaneously. Nanoliposomes and tocosomes are able to provide protection and release of sensitive food-grade bioactive materials in a sustained manner. They are being utilized for the encapsulation of different types of bioactive materials (such as drugs, vaccines, antimicrobials, antioxidants, minerals and preservatives), for the enrichment and fortification of different food and nutraceutical formulations and manufacturing of functional products. However, a number of issues unique to the nutraceutical and food industry must first be resolved before these applications can completely become a reality. Considering the potentials and promises of these colloidal carrier systems, the present article reviews various aspects of nanoliposomes, in comparison with tocosomes, including the ingredients used in their manufacture, formation mechanisms and issues pertaining to their application in the formulation of health promoting dietary supplements and functional food products.

Dermal targeting of tacrolimus using colloidal carrier systems

2011 ◽  
Vol 404 (1-2) ◽  
pp. 159-168 ◽  
Author(s):  
Alexandra S.B. Goebel ◽  
Reinhard H.H. Neubert ◽  
Johannes Wohlrab
Keyword(s):  
Colloidal Carrier ◽  
Carrier Systems

scholarly journals Dermal Peptide Delivery Using Enhancer Molecules and Colloidal Carrier Systems – Part I: Carnosine

2012 ◽  
Vol 25 (6) ◽  
pp. 281-287 ◽  
Author(s):  
A.S.B. Goebel ◽  
G. Schmaus ◽  
R.H.H. Neubert ◽  
J. Wohlrab
Keyword(s):  
Peptide Delivery ◽  
Colloidal Carrier ◽  
Carrier Systems

scholarly journals Applications of Polymeric and Lipid Nanoparticles in Ophthalmic Pharmaceutical Formulations: Present and Future Considerations

2014 ◽  
Vol 17 (3) ◽  
pp. 278 ◽  
Author(s):  
Hugo Almeida ◽  
Maria Helena Amaral ◽  
Paulo Lobão ◽  
Ana C Silva ◽  
José Manuel Sousa Loboa
Keyword(s):  
Targeted Delivery ◽  
Pharmaceutical Formulations ◽  
Lipid Nanoparticles ◽  
Routes Of Administration ◽  
Gelling Properties ◽  
Ophthalmic Administration ◽  
Ocular Drugs ◽  
New Generation ◽  
Colloidal Carrier ◽  
Carrier Systems

The unique properties and characteristics of ocular tissues and the whole set of defence mechanisms of the ocular globe make the instillation of ocular drugs into a difficult task with a low rate of therapeutic response. One of the challenges for the new generation of ophthalmic pharmaceutical formulations is to increase the bioavailability of drugs administered by the ocular route and, therefore, their therapeutic efficacy. This can be achieved with the use of some strategies that provide an increase in the formulation pre-corneal residence time, mucoadhesion and penetration across the eye tissues. Colloidal carrier systems have been very successfully used for the selective and targeted delivery of drugs for several routes of administration. In this context, nanoparticles prepared with specific polymers or lipids and coated, dispersed or suspended in polymer solutions with mucoadhesion properties or in situ gelling properties will be an excellent strategy that deserves attention and further research. In this review, the characteristics and main properties of polymeric and lipid nanoparticles are discussed and examples and advantages of the application of these colloidal carrier systems for the ophthalmic administration of drugs are presented. The future directions of the research required in this specific field are also presented.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Sign in / Sign up

Export Citation Format

Share Document