Dermal Peptide Delivery Using Enhancer Molecules and Colloidal Carrier Systems – Part IV: Search for an Alternative Model Membrane for Future ATR Permeation Studies Using PKEK as the Model Substance

2019 ◽  
Vol 32 (3) ◽  
pp. 151-161
Author(s):  
Ann-Christin Foerster ◽  
Reinhard H.H. Neubert
Keyword(s):  
Alternative Model ◽  
Peptide Delivery ◽  
Model Membrane ◽  
Model Substance ◽  
Permeation Studies ◽  
Colloidal Carrier ◽  
Carrier Systems

scholarly journals Dermal Peptide Delivery Using Enhancer Molecules and Colloidal Carrier Systems – Part I: Carnosine

2012 ◽  
Vol 25 (6) ◽  
pp. 281-287 ◽  
Author(s):  
A.S.B. Goebel ◽  
G. Schmaus ◽  
R.H.H. Neubert ◽  
J. Wohlrab
Keyword(s):  
Peptide Delivery ◽  
Colloidal Carrier ◽  
Carrier Systems

Dermal peptide delivery using enhancer molecules and colloidal carrier systems. Part III: Tetrapeptide GEKG

2018 ◽  
Vol 124 ◽  
pp. 137-144 ◽  
Author(s):  
Elfi Sommer ◽  
Reinhard H.H. Neubert ◽  
Matthias Mentel ◽  
Benjamin Tuchscherer ◽  
Yahja Mrestani ◽  
...  
Keyword(s):  
Peptide Delivery ◽  
Colloidal Carrier ◽  
Carrier Systems

Dermal Peptide Delivery Using Colloidal Carrier Systems

2008 ◽  
Vol 21 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Alexandra Goebel ◽  
Reinhard H.H. Neubert
Keyword(s):  
Peptide Delivery ◽  
Colloidal Carrier ◽  
Carrier Systems

Dermal peptide delivery using enhancer moleculs and colloidal carrier systems. Part II: Tetrapeptide PKEK

2018 ◽  
Vol 124 ◽  
pp. 28-33 ◽  
Author(s):  
Reinhard H.H. Neubert ◽  
Elfi Sommer ◽  
Melanie Schölzel ◽  
Benjamin Tuchscherer ◽  
Yahja Mrestani ◽  
...  
Keyword(s):  
Peptide Delivery ◽  
Colloidal Carrier ◽  
Carrier Systems

scholarly journals Case studies of enhanced pharmacodynamic activity of poorly oral bioavailable drugs via solid lipid nanoparticles

2021 ◽  
Vol 11 (2) ◽  
pp. 204-208
Author(s):  
D Raju
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Absorption ◽  
Lipid Nanoparticles ◽  
Lymphatic Transport ◽  
Therapeutic Effectiveness ◽  
Therapeutic Activity ◽  
Solid Lipid ◽  
Current Review ◽  
Colloidal Carrier ◽  
Carrier Systems

Solid lipid nanoparticles (SLNs) considered as an alternative vehicle for the enhanced oral absorption of drugs, and also to enhance therapeutic effectiveness after oral administration. Pharmacodynamic activity of drug is mainly describes the pharmacological and therapeutic activity of drug to the biological system. Lipid nanoparticles especially SLNs made of physiological inert lipid molecules and helps the lymphatic transport. Numerous literatures is available on the effect of SLNs and other colloidal carrier systems on the pharmacokinetic activity of poorly bioavailable drugs, to improve their oral absorption and also respective mechanisms for the improved oral bioavailability. However, very few literatures is reported on the pharmacodynamic activity and the effect of dose on the pharmacodynamic activity. Therefore, the current review is mainly dealing with the effect of SLNs on the pharmacodynamic activity discussed.   Keywords: Oral absorption, solid lipid nanoparticles, lymphatic transport, pharmacokinetics, pharmacodynamics.

Lipid Nanoparticles and Active Natural Compounds: A Perfect Combination for Pharmaceutical Applications

2019 ◽  
Vol 26 (24) ◽  
pp. 4681-4696 ◽  
Author(s):  
Carmelo Puglia ◽  
Rosario Pignatello ◽  
Virginia Fuochi ◽  
Pio Maria Furneri ◽  
Maria Rosaria Lauro ◽  
...  
Keyword(s):  
Water Solubility ◽  
Chemical Nature ◽  
Natural Compounds ◽  
Lipid Nanoparticles ◽  
Pharmaceutical Applications ◽  
Therapeutic Properties ◽  
Colloidal Carrier ◽  
Carrier Systems ◽  
Active Natural ◽  
Significant Health

Phytochemicals represent an important class of bioactive compounds characterized by significant health benefits. Notwithstanding these important features, their potential therapeutic properties suffer from poor water solubility and membrane permeability limiting their approach to nutraceutical and pharmaceutical applications. Lipid nanoparticles are well known carrier systems endowed with high biodegradation and an extraordinary biocompatible chemical nature, successfully used as platform for advanced delivery of many active compounds, including the oral, topical and systemic routes. This article is aimed at reviewing the last ten years of studies about the application of lipid nanoparticles in active natural compounds reporting examples and advantages of these colloidal carrier systems.

Colloidal Carrier Systems for Transcutaneous Immunization

2011 ◽  
Vol 12 (4) ◽  
pp. 579-597 ◽  
Author(s):  
Prem N. Gupta ◽  
Suresh P. Vyas
Keyword(s):  
Transcutaneous Immunization ◽  
Colloidal Carrier ◽  
Carrier Systems

scholarly journals Nanoliposomes and Tocosomes as Multifunctional Nanocarriers for the Encapsulation of Nutraceutical and Dietary Molecules

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 638 ◽  
Author(s):  
Ali Zarrabi ◽  
Mandana Alipoor Amro Abadi ◽  
Sepideh Khorasani ◽  
M.-Reza Mohammadabadi ◽  
Aniseh Jamshidi ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Formation Mechanisms ◽  
Bioactive Materials ◽  
Health Promoting ◽  
Nanoscale Object ◽  
Multifunctional Nanocarriers ◽  
Spherical Vesicles ◽  
Colloidal Carrier ◽  
Carrier Systems ◽  
Hydrophobic Material

Nanoscale lipid bilayers, or nanoliposomes, are generally spherical vesicles formed by the dispersion of phospholipid molecules in a water-based medium by energy input. The other nanoscale object discussed in this entry, i.e., tocosome, is a recently introduced bioactive carrier made mainly from tocopheryl phosphates. Due to their bi-compartmental structure, which consists of lipidic and aqueous compartments, these nanocarriers are capable of carrying hydrophilic and hydrophobic material separately or simultaneously. Nanoliposomes and tocosomes are able to provide protection and release of sensitive food-grade bioactive materials in a sustained manner. They are being utilized for the encapsulation of different types of bioactive materials (such as drugs, vaccines, antimicrobials, antioxidants, minerals and preservatives), for the enrichment and fortification of different food and nutraceutical formulations and manufacturing of functional products. However, a number of issues unique to the nutraceutical and food industry must first be resolved before these applications can completely become a reality. Considering the potentials and promises of these colloidal carrier systems, the present article reviews various aspects of nanoliposomes, in comparison with tocosomes, including the ingredients used in their manufacture, formation mechanisms and issues pertaining to their application in the formulation of health promoting dietary supplements and functional food products.

Dermal targeting of tacrolimus using colloidal carrier systems

2011 ◽  
Vol 404 (1-2) ◽  
pp. 159-168 ◽  
Author(s):  
Alexandra S.B. Goebel ◽  
Reinhard H.H. Neubert ◽  
Johannes Wohlrab
Keyword(s):  
Colloidal Carrier ◽  
Carrier Systems
Sign in / Sign up

Export Citation Format

Share Document