scholarly journals Liver X Receptors (LXRs) Regulate Apolipoprotein AIV-Implications of the Antiatherosclerotic Effect of LXR Agonists

2004 ◽  
Vol 18 (8) ◽  
pp. 2000-2010 ◽  
Author(s):  
Yu Liang ◽  
Xian-Cheng Jiang ◽  
Ruijie Liu ◽  
Guosheng Liang ◽  
Thomas P. Beyer ◽  
...  
Keyword(s):  
Liver X Receptors ◽  
Antiatherosclerotic Effect ◽  
X Receptors ◽  
Lxr Agonists

scholarly journals Liver X Receptors as potential therapeutic targets in atherosclerosis

2009 ◽  
Vol 32 (5) ◽  
pp. 383 ◽  
Author(s):  
Yanfei Zhu ◽  
Yousheng Li
Keyword(s):  
Cardiovascular Disease ◽  
First Generation ◽  
Cholesterol Transport ◽  
Therapeutic Effects ◽  
Liver X Receptors ◽  
Hepatic Lipogenesis ◽  
Current State ◽  
Selective Agonists ◽  
X Receptors ◽  
Lxr Agonists

Purpose: Atherosclerosis is the primary independent risk factor of cardiovascular disease, and Liver X Receptors (LXR? and LXR?) activation may play an anti-atherosclerosis effect. In this article, we summarize the current state of knowledge of roles of LXRs in physiology and homeostasis as well as the links between LXR action and atherosclerosis, and discuss the potential therapeutic effects of LXR agonists. Source: A MEDLINE database search was performed to identify relevant articles using the keywords “liver X receptors”, “LXRs”, and “atherosclerosis”. Additional papers were identified by a manual research of the references from the key articles. Principle findings: Both LXR isoforms promote reverse cholesterol transport (RCT) and have anti-inflammatory activity. LXR? is the predominant receptor in the liver regulating triglyceride synthesis. The antiatherosclerotic ability of LXRs makes them attractive targets for drugs for the treatment of cardiovascular disease. However, LXR activation induces lipogenesis and hypertriglyceridemia. The first-generation synthetic ligands of LXR increase hepatic lipogenesis and plasma triglyceride levels. New LXR ligands need to be designed without undesirable side effects. Conclusion: LXR ?-selective agonists and LXR modulators, which act as agonists in macrophages and induce cholesterol efflux while as antagonists of lipogenesis in the liver, are two critical and attractive approaches to treat atherosclerosis and cardiovascular diseases.

Liver X receptor: from metabolism to cancer

2014 ◽  
Vol 459 (2) ◽  
pp. e1-e3 ◽  
Author(s):  
Nicolas Venteclef ◽  
Pascal Ferré
Keyword(s):  
Mammalian Cells ◽  
Interferon Γ ◽  
Liver X Receptors ◽  
Biochemical Journal ◽  
Important Regulator ◽  
Ifn Γ ◽  
New Perspective ◽  
X Receptors ◽  
And Function ◽  
Lxr Agonists

Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Accumulation of cholesterol and its intermediates, such as oxysterols, lead to activation of the nuclear receptors LXRs (liver X receptors). LXR is an important regulator of cholesterol homoeostasis by controlling its transport and its neo-synthesis. Accumulating evidence indicates that the endogenous ligands of LXRs, oxysterols, play an active and important role in regulating the fate and function of immune cells. Indeed, LXRs are negative regu-lators of innate immunity by interfering with macrophage activation. Recent advances have highlighted a controversial role for LXR in cancer. In this issue of the Biochemical Journal, Wang et al. propose that LXR agonist directly controls IFN-γ (interferon-γ) expression, which limits tumour growth. This protective effect mediated by LXR appears to be dependent on IFN-γ. Thus, despite accumulation of endogenous ligand of LXR in cancer, activation of LXR seems protective. This novel evidence provides a new perspective for targeting LXR in cancer, although controversial studies can be also found in the literature. In order to avoid side effects associated with LXR agonists, molecular and cellular studies are required to decipher this unexpected action of LXRs.

Using integrative lipid systems biology to understand the role of Liver X receptors (LXRs) in male reproduction

2018 ◽  
Author(s):  
Sheba Jarvis ◽  
Lee Gethings ◽  
Raffaella Gadeleta ◽  
Emmanuelle Claude ◽  
Robert Winston ◽  
...  
Keyword(s):  
Systems Biology ◽  
Male Reproduction ◽  
Liver X Receptors ◽  
X Receptors

Chromene and chromone derivatives as liver X receptors modulators from a marine-derived Pestalotiopsis neglecta fungus

2021 ◽  
pp. 104927
Author(s):  
Zhi Liang ◽  
Tanwei Gu ◽  
Jianjiao Wang ◽  
Jianglian She ◽  
Yuxiu Ye ◽  
...  
Keyword(s):  
Liver X Receptors ◽  
Chromone Derivatives ◽  
X Receptors ◽  
Pestalotiopsis Neglecta

scholarly journals Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer

2021 ◽  
Author(s):  
Wanting Shao ◽  
Christina Kuhn ◽  
Doris Mayr ◽  
Nina Ditsch ◽  
Magdalena Kailuwait ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Poor Prognosis ◽  
Early Stage ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Parameters ◽  
Liver X Receptors ◽  
X Receptors ◽  
Independent Marker ◽  
Overall Survival Analysis

Abstract Purpose The aim of this study was to investigate the expression of liver X receptors α/β (LXR) in primary breast cancer (BC) tissues and to analyze its correlations with clinicopathological parameters including patient survival. Methods In a well-characterized cohort of 305 primary BC, subcellular distribution of LXR was evaluated by immunohistochemistry. Correlations with clinicopathological characteristics as well as with patient outcome were analyzed. Results LXR was frequently localized in both nuclei and cytoplasms of BC cells, with stronger staining in nuclei. Total and nuclear LXR expression was positively correlated with ER and PR status. Overall survival analysis demonstrated that cytoplasmic LXR was significantly correlated with poor survival and appeared as an independent marker of poor prognosis, in stage I but not in stage II–III tumors Conclusion Altogether, these data suggest that cytoplasmic LXR could be defined as a prognostic marker in early stage primary BC.

scholarly journals Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

2013 ◽  
Vol 18 (1) ◽  
pp. 106-117 ◽  
Author(s):  
Simon W. Beaven ◽  
Aleksey Matveyenko ◽  
Kevin Wroblewski ◽  
Lily Chao ◽  
Damien Wilpitz ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver X Receptors ◽  
Reciprocal Regulation ◽  
X Receptors

scholarly journals Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein

Hepatology ◽  
2015 ◽  
Vol 62 (2) ◽  
pp. 615-626 ◽  
Author(s):  
Fiona O'Mahony ◽  
Kevin Wroblewski ◽  
Sheila M. O'Byrne ◽  
Hongfeng Jiang ◽  
Kara Clerkin ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Liver X Receptors ◽  
X Receptors ◽  
Lipid Stores ◽  
Lipid Droplet Protein

scholarly journals Liver X Receptors Control IgE Expression in B Cells

2009 ◽  
Vol 182 (9) ◽  
pp. 5276-5282 ◽  
Author(s):  
Guido Heine ◽  
Anja Dahten ◽  
Kerstin Hilt ◽  
Dennis Ernst ◽  
Milena Milovanovic ◽  
...  
Keyword(s):  
B Cells ◽  
Liver X Receptors ◽  
X Receptors
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