scholarly journals Liver X Receptors Control IgE Expression in B Cells

2009 ◽  
Vol 182 (9) ◽  
pp. 5276-5282 ◽  
Author(s):  
Guido Heine ◽  
Anja Dahten ◽  
Kerstin Hilt ◽  
Dennis Ernst ◽  
Milena Milovanovic ◽  
...  
Keyword(s):  
B Cells ◽  
Liver X Receptors ◽  
X Receptors

Using integrative lipid systems biology to understand the role of Liver X receptors (LXRs) in male reproduction

2018 ◽  
Author(s):  
Sheba Jarvis ◽  
Lee Gethings ◽  
Raffaella Gadeleta ◽  
Emmanuelle Claude ◽  
Robert Winston ◽  
...  
Keyword(s):  
Systems Biology ◽  
Male Reproduction ◽  
Liver X Receptors ◽  
X Receptors

Chromene and chromone derivatives as liver X receptors modulators from a marine-derived Pestalotiopsis neglecta fungus

2021 ◽  
pp. 104927
Author(s):  
Zhi Liang ◽  
Tanwei Gu ◽  
Jianjiao Wang ◽  
Jianglian She ◽  
Yuxiu Ye ◽  
...  
Keyword(s):  
Liver X Receptors ◽  
Chromone Derivatives ◽  
X Receptors ◽  
Pestalotiopsis Neglecta

scholarly journals Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer

2021 ◽  
Author(s):  
Wanting Shao ◽  
Christina Kuhn ◽  
Doris Mayr ◽  
Nina Ditsch ◽  
Magdalena Kailuwait ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Poor Prognosis ◽  
Early Stage ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Parameters ◽  
Liver X Receptors ◽  
X Receptors ◽  
Independent Marker ◽  
Overall Survival Analysis

Abstract Purpose The aim of this study was to investigate the expression of liver X receptors α/β (LXR) in primary breast cancer (BC) tissues and to analyze its correlations with clinicopathological parameters including patient survival. Methods In a well-characterized cohort of 305 primary BC, subcellular distribution of LXR was evaluated by immunohistochemistry. Correlations with clinicopathological characteristics as well as with patient outcome were analyzed. Results LXR was frequently localized in both nuclei and cytoplasms of BC cells, with stronger staining in nuclei. Total and nuclear LXR expression was positively correlated with ER and PR status. Overall survival analysis demonstrated that cytoplasmic LXR was significantly correlated with poor survival and appeared as an independent marker of poor prognosis, in stage I but not in stage II–III tumors Conclusion Altogether, these data suggest that cytoplasmic LXR could be defined as a prognostic marker in early stage primary BC.

scholarly journals Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

2013 ◽  
Vol 18 (1) ◽  
pp. 106-117 ◽  
Author(s):  
Simon W. Beaven ◽  
Aleksey Matveyenko ◽  
Kevin Wroblewski ◽  
Lily Chao ◽  
Damien Wilpitz ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver X Receptors ◽  
Reciprocal Regulation ◽  
X Receptors

scholarly journals Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein

Hepatology ◽  
2015 ◽  
Vol 62 (2) ◽  
pp. 615-626 ◽  
Author(s):  
Fiona O'Mahony ◽  
Kevin Wroblewski ◽  
Sheila M. O'Byrne ◽  
Hongfeng Jiang ◽  
Kara Clerkin ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Liver X Receptors ◽  
X Receptors ◽  
Lipid Stores ◽  
Lipid Droplet Protein

Liver X receptors: new players in atherogenesis?

2003 ◽  
Vol 14 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Virginie Bocher ◽  
Lesley J. Millatt ◽  
Jean-Charles Fruchart ◽  
Bart Staels
Keyword(s):  
Liver X Receptors ◽  
X Receptors

Liver X receptors: new drug targets to treat Type 2 diabetes?

2006 ◽  
Vol 1 (2) ◽  
pp. 181-189 ◽  
Author(s):  
Knut R Steffensen ◽  
Jan-Åke Gustafsson
Keyword(s):  
Type 2 Diabetes ◽  
Drug Targets ◽  
Liver X Receptors ◽  
New Drug ◽  
X Receptors

Stress as an immunomodulator: liver X receptors maybe the answer

2018 ◽  
Vol 27 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Issam Nessaibia ◽  
Allan Fouache ◽  
Jean-Marc A. Lobaccaro ◽  
Abdelkrim Tahraoui ◽  
Amalia Trousson ◽  
...  
Keyword(s):  
Liver X Receptors ◽  
X Receptors
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