scholarly journals Reductions in Basal Metabolic Rate and Physical Activity Contribute to Hypothalamic Obesity

2008 ◽  
Vol 93 (7) ◽  
pp. 2588-2593 ◽  
Author(s):  
M. Guftar Shaikh ◽  
Richard G. Grundy ◽  
Jeremy M. W. Kirk
Keyword(s):  
Physical Activity ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Hypothalamic Obesity

scholarly journals Significance of variation in basal metabolic rate in laboratory mice for translational experiments

2021 ◽  
Author(s):  
Paweł Brzęk ◽  
Andrzej Gębczyński ◽  
Piotr Selewestruk ◽  
Aneta Książek ◽  
Julita Sadowska ◽  
...  
Keyword(s):  
Physical Activity ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Activity Level ◽  
Laboratory Mice ◽  
Ambient Temperatures ◽  
Thermoneutral Zone ◽  
Significant Difference ◽  
The Mean ◽  
Spontaneous Physical Activity

AbstractThe basal metabolic rate (BMR) accounts for 60–70% of the daily energy expenditure (DEE) in sedentary humans and at least 50% of the DEE in laboratory mice in the thermoneutral zone. Surprisingly, however, the significance of the variation in the BMR is largely overlooked in translational research using such indices as physical activity level (PAL), i.e., the ratio of DEE/BMR. In particular, it is unclear whether emulation of human PAL in mouse models should be carried out within or below the thermoneutral zone. It is also unclear whether physical activity within the thermoneutral zone is limited by the capacity to dissipate heat generated by exercise and obligatory metabolic processes contributing to BMR. We measured PAL and spontaneous physical activity (SPA) in laboratory mice from two lines, divergently selected towards either high or low level of BMR, and acclimated to 30 °C (i.e., the thermoneutral zone), 23 or 4 °C. The mean PAL did not differ between both lines in the mice acclimated to 30 °C but became significantly higher in the low BMR mouse line at the lower ambient temperatures. Acclimation to 30 °C reduced the mean locomotor activity but did not affect the significant difference observed between the selected lines. We conclude that carrying out experiments within the thermoneutral zone can increase the consistency of translational studies aimed at the emulation of human energetics, without affecting the variation in physical activity correlated with BMR.

scholarly journals Physical Activity, Nutritional Status, Basal Metabolic Rate, and Total Energy Expenditure of Indonesia Migrant Workers during Covid-19 Pandemic

2020 ◽  
Vol 5 (2) ◽  
Author(s):  
I Putu Agus Dharma Hita ◽  
B. M. Wara Kushartanti ◽  
Fitri Agung Nanda
Keyword(s):  
Physical Activity ◽  
Energy Expenditure ◽  
Nutritional Status ◽  
Metabolic Rate ◽  
Total Energy ◽  
Basal Metabolic Rate ◽  
Migrant Workers ◽  
Physical Activity Level ◽  
Total Energy Expenditure ◽  
Activity Level

Physical activity, nutritional status, and total energy expenditure are important components of a human. The purpose of this study was to find out the depiction of physical activity, nutritional status, basal metabolic rate, and total energy expenditure of Indonesia migrant workers during Covid-19 pandemic. The study was a survey study with a descriptive design. The samples were 86 Indonesia migrant workers. The instrument used was the 24 hour recall physical activity sheet for 14 days. The result of the study showed that: 88% of male samples and 95% of female samples gained physical activity level score in low category. The PAL score of the male samples was 1.56, while the PAL score of female samples was 1.52. Related to body mass index, 51% of Indonesia migrant workers were in the normal category; 27% were in the overweight category; 17% were in the Obese I Category, and 5% were in the Obese II category. 22 Indonesia migrant workers in overweight category had low physical activity category, 15 persons in Obesity I category had low physical activity category, and 4 persons in Obese II category. The average of the BMR of the samples during the quarantine, due to Covid-19 pandemic, was 1669 kkal/day for male and 1335 kkal/day for female. The average of total energy expenditure of the samples during Covid-19 quarantine was 2595 kkal/day for male and 2031 kkal/day for female. The physical activity level was low, the nutrition status was normal, total energy expenditure was low, the BMR of the sample was dominated by age factor, sex, and weight of the sample. The result of the study was expected to be a reference of regional and other quarantine systems to improve the immunity system during the 14 days of quarantine.

scholarly journals Enegy expenditure, physical activity and basal metabolic rate of elderly subjects

1995 ◽  
Vol 73 (4) ◽  
pp. 571-581 ◽  
Author(s):  
Daphne L.E. Pannemans ◽  
Klaas R. Westerterp
Keyword(s):  
Physical Activity ◽  
Young Adults ◽  
Energy Expenditure ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Nutrient Intake ◽  
The Elderly ◽  
Activity Level ◽  
Positive Effect ◽  
Energy And Nutrient Intake

Energy expenditure, and therefore energy requirement, generally decreases with advancing age because of a decrease in basal metabolic rate (BMR) and physical activity. The aim of the present study was to measure total energy expenditure (EE) and activity level in a group of healthy elderly (sixteen men aged 71·3 (SD 4·9) years; ten women aged 67·6 (SD 4·1) years) and young adults (nineteen men aged 30·4 (SD 5·0) years; ten women aged 27·2 (SD 3·9) years) by using the doubly-labelled water method in combination with measurements of BMR. Age-related differences in body composition and their relationship to BMR and activity level were studied. EE was lower in elderly compared with young adults, partly due to a significantly lower BMR. The lower BMR was not fully explained by the lower fat-free mass (FFM) in the elderly. Energy expended (MJ/d) on activity was higher for the younger subjects although there was no significant difference in the physical activity index (PAI = EE/BMR) between the two age groups. The effect of physical activity level is twofold: first it has a positive effect on the BMR, and second it has a positive effect on the FFM. Both effects involve an increase in the total EE with an increased level of physical activity. At energy balance this will lead to increased energy and nutrient intake, making especially the elderly less vulnerable to inadequate energy and nutrient intake.

Simulated weightlessness alters the nycthemeral distribution of energy expenditure in rats

2001 ◽  
Vol 204 (23) ◽  
pp. 4107-4113
Author(s):  
Stéphane Blanc ◽  
Alain Géloën ◽  
Sylvie Normand ◽  
Claude Gharib ◽  
Laurence Somody
Keyword(s):  
Physical Activity ◽  
Energy Expenditure ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Male Rats ◽  
Metabolic Rates ◽  
Tail Suspension ◽  
Simulated Weightlessness ◽  
Basal Energy Expenditure ◽  
The Cost

SUMMARY The energy metabolism adaptations to simulated weightlessness in rats by hindlimb tail suspension are unknown. 12 male rats were assigned to 7 days of isolation, 7 days of habituation to the suspension device, 10 days of simulated weightlessness, and 3 days of recovery. The 24-hour energy expenditure was measured by continuous indirect calorimetry. We calculated the 12-hour energy expenditure during the active (night) and inactive (day) periods, the minimal observed metabolic rates with the day values taken as an index of the basal metabolic rate, and the non-basal energy expenditure representing the cost of physical activity plus the diet-induced thermogenesis. Suspension did not change the mean 24-hour energy expenditure (360.8±15.3 J min–1 kg–0.67), but reduced the night/day difference by 64 % (P<0.05) through a concomitant drop in night-energy expenditure and increase in day values. The difference between night and day minimal metabolic rates was reduced by 81 % (P<0.05), and the transient rise in day values suggests an early and moderate basal metabolic rate increase (9 %). An overall 19 % reduction in non-basal energy expenditure was observed during simulated weightlessness (P<0.05), which was mainly attributable to a reduction in the cost of physical activity. 3 days of recovery restored the night/day differences but increased the 24-hour energy expenditure by 10 % (P<0.05). In conclusion, hindlimb tail suspension in rats did not alter the 24-hour energy expenditure, but it transiently increased the basal metabolic rate, and altered both the energy expended on physical activity and the nycthemeral distribution of motor activity. These data suggest that the circadian rhythms of energy expenditure are affected during simulated weightlessness.

scholarly journals FTO Variant, Energy Intake, Physical Activity and Basal Metabolic Rate in Caucasians. The HAPIEE Study

2011 ◽  
pp. 175-183 ◽  
Author(s):  
J. A. HUBÁČEK ◽  
H. PIKHART ◽  
A. PEASEY ◽  
R. KUBÍNOVÁ ◽  
M. BOBÁK
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Metabolic Rate ◽  
Energy Intake ◽  
Basal Metabolic Rate ◽  
Dietary Energy ◽  
Genetic Determinants ◽  
Mediating Role ◽  
Diet And Physical Activity

The FTO gene variants are the most important genetic determinants of body weight and obesity known so far, but the mechanism of their effect remains unclear. We have analyzed FTO rs17817449 variant (G>T in first intron) in 6024 adults aged 45-69 years to assess the potential mediating role of diet and physical activity. Diet was assessed by a 140-item food frequency questionnaire. Physical activity was measured by hours spent during a typical week by sport, walking and other activities outside of work requiring heavy and medium physical activity. Basal metabolic rate was calculated according Schofield formula. The FTO variant was significantly associated with body mass index (means in GG, GT and TT carriers were 28.7, 28.2 and 27.8 kg/m2, p<0.001) and basal metabolic rate (BMR) (means in GG, GT and TT were 1603, 1588 and 1576 kcal per day, respectively, p<0.008) but it was not associated with physical activity, total energy intake or with energy intakes from fat, carbohydrates, proteins or alcohol. Results were essentially similar in men and women and the adjustment for physical activity or dietary energy intake did not reduce the effect of the FTO polymorphism. Means of BMR per kg of body weight was lowest in GG carriers (20.09, 20.21 for GT and 20.30 for TT, p<0.006) and this effect was more pronounced in females. These results suggest that the effect of the FTO rs17817449 variant on BMI in Caucasian adults is not mediated by energy intake or physical activity, but some effect on BMR per kg of body weight is possible.

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