Effect of calorie restriction on spontaneous physical activity and body mass in mice divergently selected for basal metabolic rate (BMR)

2016 ◽  
Vol 161 ◽  
pp. 116-122 ◽  
Author(s):  
Paweł Brzęk ◽  
Andrzej K. Gębczyński ◽  
Aneta Książek ◽  
Marek Konarzewski
Keyword(s):  
Physical Activity ◽  
Metabolic Rate ◽  
Body Mass ◽  
Calorie Restriction ◽  
Basal Metabolic Rate ◽  
Spontaneous Physical Activity

scholarly journals Significance of variation in basal metabolic rate in laboratory mice for translational experiments

2021 ◽  
Author(s):  
Paweł Brzęk ◽  
Andrzej Gębczyński ◽  
Piotr Selewestruk ◽  
Aneta Książek ◽  
Julita Sadowska ◽  
...  
Keyword(s):  
Physical Activity ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Activity Level ◽  
Laboratory Mice ◽  
Ambient Temperatures ◽  
Thermoneutral Zone ◽  
Significant Difference ◽  
The Mean ◽  
Spontaneous Physical Activity

AbstractThe basal metabolic rate (BMR) accounts for 60–70% of the daily energy expenditure (DEE) in sedentary humans and at least 50% of the DEE in laboratory mice in the thermoneutral zone. Surprisingly, however, the significance of the variation in the BMR is largely overlooked in translational research using such indices as physical activity level (PAL), i.e., the ratio of DEE/BMR. In particular, it is unclear whether emulation of human PAL in mouse models should be carried out within or below the thermoneutral zone. It is also unclear whether physical activity within the thermoneutral zone is limited by the capacity to dissipate heat generated by exercise and obligatory metabolic processes contributing to BMR. We measured PAL and spontaneous physical activity (SPA) in laboratory mice from two lines, divergently selected towards either high or low level of BMR, and acclimated to 30 °C (i.e., the thermoneutral zone), 23 or 4 °C. The mean PAL did not differ between both lines in the mice acclimated to 30 °C but became significantly higher in the low BMR mouse line at the lower ambient temperatures. Acclimation to 30 °C reduced the mean locomotor activity but did not affect the significant difference observed between the selected lines. We conclude that carrying out experiments within the thermoneutral zone can increase the consistency of translational studies aimed at the emulation of human energetics, without affecting the variation in physical activity correlated with BMR.

Effect of Calorie Restriction on Resting Metabolic Rate and Spontaneous Physical Activity**

Obesity ◽  
2007 ◽  
Vol 15 (12) ◽  
pp. 2964-2973 ◽  
Author(s):  
Corby K. Martin ◽  
Leonie K. Heilbronn ◽  
Lilian de Jonge ◽  
James P. DeLany ◽  
Julia Volaufova ◽  
...  
Keyword(s):  
Physical Activity ◽  
Metabolic Rate ◽  
Calorie Restriction ◽  
Resting Metabolic Rate ◽  
Spontaneous Physical Activity

The relationship between body mass and rate of rewarming from hibernation and daily torpor in mammals

1990 ◽  
Vol 151 (1) ◽  
pp. 349-359 ◽  
Author(s):  
F. Geiser ◽  
R. V. Baudinette
Keyword(s):  
Metabolic Rate ◽  
Body Mass ◽  
Air Temperature ◽  
Basal Metabolic Rate ◽  
Strong Relationship ◽  
The Other ◽  
Daily Torpor ◽  
Pronounced Increase ◽  
The Relationship

1. Rewarming rate from torpor and body mass were inversely related in 86 mammals ranging in body mass between 2 and 8500 g. 2. Most of the mammalian taxa investigated showed a similar change of rewarming rate with body mass. Only the insectivores showed a more pronounced increase in rewarming with a decrease in body mass than did the other taxa. The rates of rewarming of marsupials were similar to those of placentals. 3. At low air temperature (Ta), the rate of rewarming of marsupials was not related to body mass, although a strong relationship between the two variables was observed in the same species at high Ta. 4. The slopes relating rewarming rates and body mass of the mammalian groups and taxa analysed here were similar to those obtained earlier for mass-specific basal metabolic rate (BMR) and body mass in mammals, suggesting that the rate of rewarming and BMR are physiologically linked.

Basal metabolic rate in adults with growth hormone deficiency and in patients with acromegaly: relationship with lean body mass, plasma insulin level and leucocyte sodium pump activity

1992 ◽  
Vol 83 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Franco Salomon ◽  
Ross C. Cuneo ◽  
Richard Hesp ◽  
Jenny F. Morris ◽  
Lucilla Poston ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Metabolic Rate ◽  
Growth Hormone Deficiency ◽  
Lean Body Mass ◽  
Body Mass ◽  
Basal Metabolic Rate ◽  
Plasma Insulin ◽  
Recombinant Human Growth Hormone ◽  
Hormone Deficiency ◽  
Sodium Efflux

1. The relationship of lean body mass, plasma insulin concentration and leucocyte active sodium transport with basal metabolic rate was investigated in 24 adults with growth hormone deficiency before and after treatment with recombinant human growth hormone and in 10 patients with untreated acromegaly. 2. Based on total-body potassium determined by whole-body 40K counting, patients with acromegaly had increased lean body mass, whereas lack of growth hormone was associated with decreased lean body mass. 3. By indirect calorimetry, patients with acromegaly had increased basal metabolic rates and patients with growth hormone deficiency had decreased values when expressed as percentages of values predicted from the WHO/FAO/UNU equations. Basal metabolic rate expressed in terms of lean body mass was similar in acromegaly and growth hormone deficiency, but was higher than normal in both patient groups. 4. The leucocyte ouabain-sensitive sodium efflux rate constant was decreased in both patients with acromegaly and patients with growth hormone deficiency, and there was no correlation with basal energy expenditure, fasting plasma insulin level or serum growth hormone level. 5. There was no increase in the sodium efflux rate constant in patients with growth hormone deficiency after 1 month on treatment with recombinant human growth hormone. 6. Apparent differences in basal metabolic rate in growth hormone deficiency and acromegaly are due to changes in lean body mass. Both adults with growth hormone deficiency and patients with acromegaly have increased energy expenditure, probably owing to changes in fuel metabolism which are not reflected in the leucocyte sodium pump activity.

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