scholarly journals Corrigendum to: “Suppressed Prostate Epithelial Development with Impaired Branching Morphogenesis in Mice Lacking Stromal Fibromuscular Androgen Receptor”

Endocrinology ◽  
2020 ◽  
Vol 161 (10) ◽  
Author(s):  
Kuo-Pao Lai ◽  
Shinichi Yamashita ◽  
Spencer Vitkus ◽  
Chih-Rong Shyr ◽  
Shuyuan Yeh ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Branching Morphogenesis ◽  
Epithelial Development

scholarly journals Suppressed Prostate Epithelial Development with Impaired Branching Morphogenesis in Mice Lacking Stromal Fibromuscular Androgen Receptor

2012 ◽  
Vol 26 (1) ◽  
pp. 52-66 ◽  
Author(s):  
Kuo-Pao Lai ◽  
Shinichi Yamashita ◽  
Spencer Vitkus ◽  
Chih-Rong Shyr ◽  
Shuyuan Yeh ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Growth Factor ◽  
Branching Morphogenesis ◽  
Placental Growth Factor ◽  
Wild Type ◽  
Wild Type Littermate ◽  
Stromal Fibroblasts ◽  
Epithelial Development ◽  
Anterior Prostate ◽  
Prostate Epithelium

Abstract Using the cre-loxP system, we generated a new mouse model [double stromal androgen receptor knockout (dARKO)] with selectively deleted androgen receptor (AR) in both stromal fibroblasts and smooth muscle cells, and found the size of the anterior prostate (AP) lobes was significantly reduced as compared with those from wild-type littermate controls. The reduction in prostate size of the dARKO mouse was accompanied by impaired branching morphogenesis and partial loss of the infolding glandular structure. Further dissection found decreased proliferation and increased apoptosis of the prostate epithelium in the dARKO mouse AP. These phenotype changes were further confirmed with newly established immortalized prostate stromal cells (PrSC) from wild-type and dARKO mice. Mechanistically, IGF-1, placental growth factor, and secreted phosphoprotein-1 controlled by stromal AR were differentially expressed in PrSC-wt and PrSC-ARKO. Moreover, the conditioned media (CM) from PrSC-wt promoted prostate epithelium growth significantly as compared with CM from PrSC-dARKO. Finally, adding IGF-1/placental growth factor recombinant proteins into PrSC-dARKO CM was able to partially rescue epithelium growth. Together, our data concluded that stromal fibromuscular AR could modulate epithelium growth and maintain cellular homeostasis through identified growth factors.

scholarly journals Disruption of Prostate Epithelial Androgen Receptor Impedes Prostate Lobe-Specific Growth and Function

Endocrinology ◽  
2007 ◽  
Vol 148 (5) ◽  
pp. 2264-2272 ◽  
Author(s):  
Ulla Simanainen ◽  
Charles M. Allan ◽  
Patrick Lim ◽  
Stephen McPherson ◽  
Mark Jimenez ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Epithelial Cells ◽  
Molecular Mechanisms ◽  
Functional Differentiation ◽  
Branching Morphogenesis ◽  
Testis Weight ◽  
Structural Differentiation ◽  
Prostate Development ◽  
Prostate Epithelium

Prostate development and maturation requires stromal-epithelial interactions and androgen action via the androgen receptor (AR) within these compartments. However, the specific roles of epithelial and stromal AR in postnatal prostate differentiation are unclear. We used Cre-LoxP technology to determine the prostate phenotype in mice with epithelial-selective genetic inactivation of the AR leaving the stromal AR functionally intact. We find that prostate development abolished in mice globally lacking a functional AR can be rescued by restricting the AR knockout to the postnatal prostate epithelium. We show that, at 8 wk of age, prostate epithelial AR knockout (PEARKO) mice exhibit prostate development with normal branching morphogenesis but lobe-specific decrease in prostate weight and hindered structural and functional differentiation of the mature prostate epithelium. No change was observed in PEARKO testis weight or serum testosterone compared with littermate controls. The most striking change was increased proliferation and abnormal lesions of epithelial cells predominantly in the anterior lobe of PEARKO mice. These findings highlight the vital role of stromal AR in postnatal prostate growth and structural differentiation and emphasize the requirement of epithelial AR in maintaining functional differentiation and restraining proliferation of epithelial cells in a lobe-specific manner. This unique PEARKO mouse provides a new paradigm with which to define the molecular mechanisms of the androgen signaling in mature prostate lobes in vivo and provides insight into the identification of better targets for treatment of prostate cancer and hyperplasia.

scholarly journals Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts

The Prostate ◽  
2011 ◽  
Vol 72 (4) ◽  
pp. 437-449 ◽  
Author(s):  
Shengqiang Yu ◽  
Chiuan-Ren Yeh ◽  
Yuanjie Niu ◽  
Hong-Chiang Chang ◽  
Yu-Chieh Tsai ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Stromal Fibroblasts ◽  
Epithelial Development

scholarly journals Altered prostate epithelial development and IGF-1 signal in mice lacking the androgen receptor in stromal smooth muscle cells

The Prostate ◽  
2010 ◽  
Vol 71 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Shengqiang Yu ◽  
Caixia Zhang ◽  
Chiu-Chun Lin ◽  
Yuanjie Niu ◽  
Kuo-Pao Lai ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Androgen Receptor ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Epithelial Development

Expression of androgen receptor and 5α-reductase types 1 and 2 in early gestation fetal lung: a possible correlation with branching morphogenesis

2003 ◽  
Vol 105 (6) ◽  
pp. 709-713 ◽  
Author(s):  
Y. KIMURA ◽  
T. SUZUKI ◽  
C. KANEKO ◽  
A. D. DARNEL ◽  
J. AKAHIRA ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Epithelial Cells ◽  
Fetal Lung ◽  
Branching Morphogenesis ◽  
Rt Pcr ◽  
Reverse Transcription Pcr ◽  
Epithelial Cell Lines ◽  
Human Fetal Lung

The bioactive and potent androgen 5α-dihydrotestosterone (DHT) has been postulated to be involved in the development of branching morphogenesis in the human fetal lung, but its expression has not been examined. We therefore examined the expression of the androgen receptor (AR) and 5α-reductases (type 1 and type 2), which catalyse the conversion of testosterone into DHT, in the human fetal lung using immunohistochemistry and reverse transcription–PCR (RT-PCR). Immunoreactive AR was detected predominantly in the nuclei of epithelial cells of the budding component of the early gestational fetal lung. 5α-Reductase type 1 immunoreactivity was detected in the cytoplasm of epithelial cells, whereas immunoreactivity for 5α-reductase type 2 was not detected in the samples of human fetal lung examined. RT-PCR also confirmed the presence of AR and 5α-reductase in all fetal lung and epithelial cell lines. The results of our present study suggest that DHT may play an important role in epithelial cells, which might include precursor cells, in which both AR and 5α-reductases are expressed during branching morphogenesis of the human fetal lung.

417: The Human Androgen Receptor Gene is a Primary Target of the WNT Signaling Pathway

2006 ◽  
Vol 175 (4S) ◽  
pp. 136-136
Author(s):  
Ralph Buttyan ◽  
Xuezhen Yang ◽  
Min-Wei Chen ◽  
Debra L. Bemis ◽  
Mitchell C. Benson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Receptor Gene ◽  
Wnt Signaling Pathway ◽  
Androgen Receptor Gene ◽  
Primary Target ◽  
Human Androgen Receptor Gene ◽  
Human Androgen Receptor

609: Effects of Sirna and Phytoestrogen Treatments on the Expression of Genes Regulated through the Androgen Receptor of Lncap Prostate Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 162-162
Author(s):  
Paul Thelen ◽  
Michal Grzmil ◽  
Iris E. Eder ◽  
Barbara Spengler ◽  
Peter Burfeind ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Expression Of Genes

Father absence, age at menarche, and sexual behaviors in women: Evaluating the genetic confounding hypothesis using the androgen receptor gene.

2019 ◽  
Vol 13 (3) ◽  
pp. 205-222 ◽  
Author(s):  
Gabriel L. Schlomer ◽  
Jessica Murray ◽  
Brianna Yates ◽  
Kerry Hair ◽  
David J. Vandenbergh
Keyword(s):  
Androgen Receptor ◽  
Sexual Behaviors ◽  
Receptor Gene ◽  
Father Absence ◽  
Androgen Receptor Gene ◽  
Age At Menarche
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