scholarly journals Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts

The Prostate ◽  
2011 ◽  
Vol 72 (4) ◽  
pp. 437-449 ◽  
Author(s):  
Shengqiang Yu ◽  
Chiuan-Ren Yeh ◽  
Yuanjie Niu ◽  
Hong-Chiang Chang ◽  
Yu-Chieh Tsai ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Stromal Fibroblasts ◽  
Epithelial Development

scholarly journals Suppressed Prostate Epithelial Development with Impaired Branching Morphogenesis in Mice Lacking Stromal Fibromuscular Androgen Receptor

2012 ◽  
Vol 26 (1) ◽  
pp. 52-66 ◽  
Author(s):  
Kuo-Pao Lai ◽  
Shinichi Yamashita ◽  
Spencer Vitkus ◽  
Chih-Rong Shyr ◽  
Shuyuan Yeh ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Growth Factor ◽  
Branching Morphogenesis ◽  
Placental Growth Factor ◽  
Wild Type ◽  
Wild Type Littermate ◽  
Stromal Fibroblasts ◽  
Epithelial Development ◽  
Anterior Prostate ◽  
Prostate Epithelium

Abstract Using the cre-loxP system, we generated a new mouse model [double stromal androgen receptor knockout (dARKO)] with selectively deleted androgen receptor (AR) in both stromal fibroblasts and smooth muscle cells, and found the size of the anterior prostate (AP) lobes was significantly reduced as compared with those from wild-type littermate controls. The reduction in prostate size of the dARKO mouse was accompanied by impaired branching morphogenesis and partial loss of the infolding glandular structure. Further dissection found decreased proliferation and increased apoptosis of the prostate epithelium in the dARKO mouse AP. These phenotype changes were further confirmed with newly established immortalized prostate stromal cells (PrSC) from wild-type and dARKO mice. Mechanistically, IGF-1, placental growth factor, and secreted phosphoprotein-1 controlled by stromal AR were differentially expressed in PrSC-wt and PrSC-ARKO. Moreover, the conditioned media (CM) from PrSC-wt promoted prostate epithelium growth significantly as compared with CM from PrSC-dARKO. Finally, adding IGF-1/placental growth factor recombinant proteins into PrSC-dARKO CM was able to partially rescue epithelium growth. Together, our data concluded that stromal fibromuscular AR could modulate epithelium growth and maintain cellular homeostasis through identified growth factors.

scholarly journals The Role of Androgen Receptor in Cross Talk Between Stromal Cells and Prostate Cancer Epithelial Cells

2021 ◽  
Vol 9 ◽  
Author(s):  
Qianyao Tang ◽  
Bo Cheng ◽  
Rongyang Dai ◽  
Ronghao Wang
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Tumor Microenvironment ◽  
Epithelial Cells ◽  
Cross Talk ◽  
Cell Invasion ◽  
Stromal Cells ◽  
Neuroendocrine Cells ◽  
Stromal Fibroblasts ◽  
Biological Regulation

Prostate cancer (PCa) lists as the second most lethal cancer for men in western countries, and androgen receptor (AR) plays a central role in its initiation and progression, which prompts the development of androgen deprivation therapy (ADT) as the standard treatment. Prostate tumor microenvironment, consisting of stromal cells and extracellular matrix (ECM), has dynamic interactions with PCa epithelial cells and affects their growth and invasiveness. Studies have shown that both genomic and non-genomic AR signaling pathways are involved in the biological regulation of PCa epithelial cells. In addition, AR signaling in prostate stroma is also involved in PCa carcinogenesis and progression. Loss of AR in PCa stroma is clinically observed as PCa progresses to advanced stage. Especially, downregulation of AR in stromal fibroblasts dysregulates the expression levels of ECM proteins, thus creating a suitable environment for PCa cells to metastasize. Importantly, ADT treatment enhances this reciprocal interaction and predisposes stromal cells to promote cell invasion of PCa cells. During this process, AR in PCa epithelium actively responds to various stimuli derived from the surrounding stromal cells and undergoes enhanced degradation while elevating the expression of certain genes such as MMP9 responsible for cell invasion. AR reduction in epithelial cells also accelerates these cells to differentiate into cancer stem-like cells and neuroendocrine cells, which are AR-negative PCa cells and inherently resistant to ADT treatments. Overall, understanding of the cross talk between tumor microenvironment and PCa at the molecular level may assist the development of novel therapeutic strategies against this disease. This review will provide a snapshot of AR’s action when the interaction of stromal cells and PCa cells occurs.

scholarly journals Altered prostate epithelial development and IGF-1 signal in mice lacking the androgen receptor in stromal smooth muscle cells

The Prostate ◽  
2010 ◽  
Vol 71 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Shengqiang Yu ◽  
Caixia Zhang ◽  
Chiu-Chun Lin ◽  
Yuanjie Niu ◽  
Kuo-Pao Lai ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Androgen Receptor ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Epithelial Development

scholarly journals Corrigendum to: “Suppressed Prostate Epithelial Development with Impaired Branching Morphogenesis in Mice Lacking Stromal Fibromuscular Androgen Receptor”

Endocrinology ◽  
2020 ◽  
Vol 161 (10) ◽  
Author(s):  
Kuo-Pao Lai ◽  
Shinichi Yamashita ◽  
Spencer Vitkus ◽  
Chih-Rong Shyr ◽  
Shuyuan Yeh ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Branching Morphogenesis ◽  
Epithelial Development

scholarly journals Effects of Androgen Receptor and Androgen on Gene Expression in Prostate Stromal Fibroblasts and Paracrine Signaling to Prostate Cancer Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e16027 ◽  
Author(s):  
Matthew J. Tanner ◽  
R. Charles Welliver ◽  
Mengqian Chen ◽  
Michael Shtutman ◽  
Alejandro Godoy ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Paracrine Signaling ◽  
Prostate Cancer Cells ◽  
Stromal Fibroblasts

417: The Human Androgen Receptor Gene is a Primary Target of the WNT Signaling Pathway

2006 ◽  
Vol 175 (4S) ◽  
pp. 136-136
Author(s):  
Ralph Buttyan ◽  
Xuezhen Yang ◽  
Min-Wei Chen ◽  
Debra L. Bemis ◽  
Mitchell C. Benson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Receptor Gene ◽  
Wnt Signaling Pathway ◽  
Androgen Receptor Gene ◽  
Primary Target ◽  
Human Androgen Receptor Gene ◽  
Human Androgen Receptor

609: Effects of Sirna and Phytoestrogen Treatments on the Expression of Genes Regulated through the Androgen Receptor of Lncap Prostate Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 162-162
Author(s):  
Paul Thelen ◽  
Michal Grzmil ◽  
Iris E. Eder ◽  
Barbara Spengler ◽  
Peter Burfeind ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Expression Of Genes

Father absence, age at menarche, and sexual behaviors in women: Evaluating the genetic confounding hypothesis using the androgen receptor gene.

2019 ◽  
Vol 13 (3) ◽  
pp. 205-222 ◽  
Author(s):  
Gabriel L. Schlomer ◽  
Jessica Murray ◽  
Brianna Yates ◽  
Kerry Hair ◽  
David J. Vandenbergh
Keyword(s):  
Androgen Receptor ◽  
Sexual Behaviors ◽  
Receptor Gene ◽  
Father Absence ◽  
Androgen Receptor Gene ◽  
Age At Menarche
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