scholarly journals Body Weight Impact on Puberty: Effects of High-Calorie Diet on Puberty Onset in Female Rhesus Monkeys

Endocrinology ◽  
2012 ◽  
Vol 153 (4) ◽  
pp. 1696-1705 ◽  
Author(s):  
Ei Terasawa ◽  
Joseph R. Kurian ◽  
Kim L. Keen ◽  
Nicholas A. Shiel ◽  
Ricki J. Colman ◽  
...  
Keyword(s):  
Body Weight ◽  
Rhesus Monkeys ◽  
Close Monitoring ◽  
Primate Research ◽  
Genetic Traits ◽  
Female Rhesus ◽  
Calorie Diet ◽  
Puberty Onset ◽  
High Calorie Diet ◽  
High Calorie

Secular trends toward a declining age at puberty onset with correlated changes in body weight have been reported in economically advanced countries. This has been attributed to excess calorie intake along with reduced physical activity in children. However, because the timing of puberty in humans is also influenced by other factors, such as genetic traits, living conditions, geographical location, and environmental chemicals, it is difficult to distinguish the effect of diet and body size from other factors in a human population. Here we report that feeding juvenile female rhesus monkeys born and raised at the Wisconsin National Primate Research Center with a high-calorie diet results in acceleration of body growth and precocious menarche. The monkeys fed a high-calorie diet also had an elevated body mass index. The most significant treatment effects on circulating hormones were increased leptin and IGF-I levels throughout the experiment. The findings of this study suggest the importance of close monitoring of juvenile feeding behaviors as an important intervention to reduce the prevalence of precocious development and metabolic diseases in adulthood.

scholarly journals THE INFLUENCE OF KIDNEY BEANS ( PHASEOLUS VULGARIS ) PODS EXTRACT ON OBESITY DEVELOPMENT

2016 ◽  
Vol 72 (2) ◽  
pp. 86-88
Author(s):  
A. Yurchenko ◽  
N. Raksha ◽  
O. Savchuk
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Food Intake ◽  
Phaseolus Vulgaris ◽  
Body Mass ◽  
Diet Group ◽  
Kidney Beans ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

The influence of kidney beans pods extract on obesity development was investigated. It was found that administration of P. vulgaris pods extract led to decrease of body weight and body mass index of the animals which were on high-calorie diet. Found changes could be result of decrease of food intake by rats treated with extract in compare with rats in high-calorie diet group.

scholarly journals Effects of Papaya Seed Oil (Carica papaya Linn.) on Food Consumption, Weight Gain and Hormones of Animals Treated With a High Calorie Diet

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1245-1245
Author(s):  
Lidiani Santana ◽  
Diana Aquino ◽  
Bruna Espirito Santo ◽  
Adriana Guércio ◽  
Mariana Tatara ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Consumption ◽  
Seed Oil ◽  
Saline Treatment ◽  
Calorie Diet ◽  
Hypercaloric Diet ◽  
High Calorie Diet ◽  
Papaya Seed ◽  
High Calorie

Abstract Objectives To evaluate the effects of papaya seed oil (Carica papaya Linn.) on food consumption, weight gain and hormonal of animals treated with a high calorie diet. Methods The project was approved by protocol no980/2018 (CEUA). Swiss, male, adult mice were used and divided into the experimental groups: control group (CT - Nuvital® diet - saline treatment), AIN-93M group (AIN-93M diet - saline treatment), HPL group (hypercaloric diet - saline treatment), HPL OS group (hypercaloric diet - soybean oil treatment), HPL AZ group (hypercaloric diet - olive oil treatment) and HPL OM group (hypercaloric diet - papaya seed oil treatment). The animals received treatment daily by gavage, 1 mL/kg, for 8 weeks. Body weight and food consumption were evaluated (Camry® analytical digital scale). At the end of the experiment, the animals were submitted to euthanasia and the blood was collected for quantification of leptin, insulin and resistin (commercial kit MADKMAG-71K®-Merck). The results were expressed as mean ± standard deviation, using Prisma 5.0 software (GraphPad Software, USA) (P ≤ 0.05).It was observed that the papaya seed oil reduced food consumption and body weight, as well as increased the concentration of leptin, maintaining insulin and resistin, thus being effective in combating the metabolic changes caused by the high fat diet. Results In the first month of the study, food consumption was lower in the HPL AZ and HPL OM groups than in the CT (P < 0.005), and in the second month all groups that received HPL diet consumed less if compared to the CT, being that HPL OM have significantly lower consumption than groups AIN-93M, CT and HPL (P < 0.05). At the beginning of the experiment, all animals were weighed and evenly distributed in the groups (P = 0.938). In the first and second weeks, HLP OM had a lower weight than HLP OS and HPL (P < 0.05). In the weeks that followed, the weight gain of the HLP OM group was lower compared to the groups that received a high-fat diet, but without significant difference. In the evaluation of the hormone leptin, a higher value was found in the HPL OM group (P < 0.001), with values of resistin and insulin similar to the control groups. Conclusions It was observed that the papaya seed oil reduced food consumption and body weight, as well as increased the concentration of leptin, maintaining insulin and resistin. Funding Sources CNPQ.

scholarly journals Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet/STZ-Induced Diabetic Rats

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 558 ◽  
Author(s):  
Jun-bo Wang ◽  
Xin-ran Liu ◽  
Si-qi Liu ◽  
Rui-xue Mao ◽  
Chao Hou ◽  
...  
Keyword(s):  
Body Weight ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Urine Volume ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Sd Rats ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

The study was aimed to determine whether treatment with oat oligopeptides (OOPs) could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in Sprague–Dawley (SD) rats. Diabetic SD rats modeling by a joint effect of high-calorie diet for 45 days and twice intraperitoneal injection of 30 mg/kg streptozotocin at one-week interval were observed with or without OOPs administration (0.25, 0.50, 1.00, and 2.00 g/kg Body Weight) for 12 weeks. Fasting blood glucose (FBG), oral glucose test tolerance (OGTT), serum insulin, level of antioxidant, and hepatic enzymes were measured. In addition, frequency of micturition was recorded in this study for the first time. It was observed that the administration of OOPs (2.00 g/kg Body Weight) resulted in a significant decrease (p < 0.05) in FBG since 6th week and a significant decrease (p < 0.05) in the OGTT-AUC on 6th and 10th week. In addition, the administration of OOPs (2.00 g/kg Body Weight) reduced HOMA-IR index and 24-h urine volume significantly (p < 0.05) whereas increased SOD activity significantly (p < 0.05). These results suggested that OOPs may have a hypoglycemic effect in diabetic rats.

scholarly journals Morphofunctional state of rat visceral white adipose tissue under obesity development and silver nanoparticles administration

2020 ◽  
Vol 83 (4) ◽  
pp. 37-43
Author(s):  
A. Pustovalov ◽  
O. Tkachenko ◽  
M. Matviienko ◽  
M. Dzerzhynsky
Keyword(s):  
Silver Nanoparticles ◽  
Body Weight ◽  
Adipose Tissue ◽  
Silver Nitrate ◽  
White Adipose Tissue ◽  
Nitrate Solution ◽  
Silver Nitrate Solution ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

There was studied the morphofunctional state of the visceral white adipose tissue of rats with obesity and after introduction of silver salt solution and silver nanoparticles solution. In particular, we analyzed the morphofunctional changes in the visceral white adipose tissue of rats on a high-calorie diet, as well as the effects of the silver nitrate solution and the silver nanoparticles solution at a dose of 1 mg / 1 kg body weight and 0.5 mg / 1 kg body weight on the morphofunctional state of the visceral white adipose tissue of rats on a high-calorie diet. There were established morphofunctional changes in cells of the rats white adipose tissue on the high-calorie diet and with the introduction of silver preparations in different concentrations. The condition of the adipose tissue was evaluated on the basis of the following parameters: the relative mass of the visceral fat, the cross-sectional area of adipocytes, the relative number of adipocytes per unit area. There were compared effects of administration to animals with obesity of the silver nitrate solution at a dose of 1 mg / 1 kg body weight and 0.5 mg / 1 kg body weight, as well as a of the silver nanoparticles solution at a dose 1 mg / 1 kg body weight and 0.5 mg / 1 kg of body weight. All the above silver preparations reduced the manifestations of obesity in animals which were maintained in a high-calorie diet. In addition to the form of the silver preparation (silver nitrate solution or silver nanoparticle solution), its concentration is important. The highest efficiency was shown after the administration of the silver nanoparticles solution at a dose 0.5 mg / 1 kg of body weight. In rats of this experimental group, the studied parameters not only reached the control values, but they also exceeded them, which indicates expressed influence of the drug on the obesity manifestations. In addition, the rats showed signs of fat depletion.

The evaluation of lipid peroxidation and oxidative modification of proteins in blood serum under obesity development and the consumption of aqueous kidney beans Phaseolus vulgaris pods extract

2020 ◽  
Vol 33 (1) ◽  
pp. 38-44
Author(s):  
Alona Yurchenko ◽  
Daryna Krenytska ◽  
Olexii Savchuk ◽  
Tetiana Halenova ◽  
Natalia Raksha ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Oxidative Modification ◽  
Resistance Development ◽  
Oxidative Modification Of Proteins ◽  
Kidney Beans ◽  
Calorie Diet ◽  
Diet Control ◽  
High Calorie Diet ◽  
High Calorie

AbstractOur interest has focused on the investigation of the anti-obese potential of kidney beans (P. vulgaris) pods extract. In the course of the study, obesity development in rats was induced with high-calorie diet. Control and obese rats then have consumed with aqueous kidney beans (P. vulgaris) pods extract during 6 weeks (200 mg/kg). Results show that the long-term consumption of P. vulgaris pods extract can lead to the reduction of hyperglycemia and insulin resistance development. Furthermore, we saw a normalization of lipid peroxidation parameters and oxidative modification of protein due to the consumption of the kidney beans (P. vulgaris) pods extract. Our experimental data demonstrate the ability of the kidney beans (P. vulgaris) pod extracts to mitigate obesity development but the details of this mechanism remains to be not fully understood.

A high calorie diet causes memory loss, metabolic syndrome and oxidative stress into hippocampus and temporal cortex of rats

Synapse ◽  
2015 ◽  
Vol 69 (9) ◽  
pp. 421-433 ◽  
Author(s):  
Samuel Treviño ◽  
Patrícia Aguilar-Alonso ◽  
Jose Angel Flores Hernandez ◽  
Eduardo Brambila ◽  
Jorge Guevara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Temporal Cortex ◽  
Memory Loss ◽  
Calorie Diet ◽  
And Oxidative Stress ◽  
High Calorie Diet ◽  
High Calorie

scholarly journals A 5-Day High-Fat, High-Calorie Diet Impairs Insulin Sensitivity in Healthy, Young South Asian Men but Not in Caucasian Men

Diabetes ◽  
2013 ◽  
Vol 63 (1) ◽  
pp. 248-258 ◽  
Author(s):  
L. E. H. Bakker ◽  
L. D. van Schinkel ◽  
B. Guigas ◽  
T. C. M. Streefland ◽  
J. T. Jonker ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
South Asian ◽  
High Fat ◽  
Asian Men ◽  
Caucasian Men ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie
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