A high calorie diet causes memory loss, metabolic syndrome and oxidative stress into hippocampus and temporal cortex of rats

Synapse ◽  
2015 ◽  
Vol 69 (9) ◽  
pp. 421-433 ◽  
Author(s):  
Samuel Treviño ◽  
Patrícia Aguilar-Alonso ◽  
Jose Angel Flores Hernandez ◽  
Eduardo Brambila ◽  
Jorge Guevara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Temporal Cortex ◽  
Memory Loss ◽  
Calorie Diet ◽  
And Oxidative Stress ◽  
High Calorie Diet ◽  
High Calorie

scholarly journals Melon GliSODin® Prevents Diet-Induced NASH Onset by Reducing Fat Synthesis and Improving Liver Function

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1779 ◽  
Author(s):  
Nakamura ◽  
Kitamura ◽  
Yokoyama ◽  
Uchida ◽  
Kumadaki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Gene Expression Analysis ◽  
Nutritional Supplement ◽  
Fat Accumulation ◽  
Calorie Diet ◽  
Fat Synthesis ◽  
And Oxidative Stress ◽  
High Calorie Diet ◽  
High Calorie

A high-calorie diet causes fat accumulation and oxidative stress in the liver, leading to fatty liver and eventually non-alcoholic steatohepatitis (NASH). Melon GliSODin® is used as a nutritional supplement because of its antioxidant activity. This study aimed to assess the antioxidant activity of Melon GliSODin® and its effectiveness in preventing NASH, which primarily results from oxidative stress. Furthermore, we verified the protective effect of Melon GliSODin® by administering it to a mouse model of diet-induced NASH. Melon GliSODin® suppressed liver fibrosis and fat accumulation, which is characteristic of the NASH phenotype. Gene expression analysis confirmed the suppression of fat synthesis and activation of antioxidative mechanisms. These results show that Melon GliSODin® mitigates NASH onset at the molecular level, suggesting its potential application as a NASH preventive agent.

Comparative effects of intragastric Lys-Arg-Аrg-Lys-Pro-Gly-Pro peptides, warfarin, and acetylsalicylic acid on hemostasis indexes and blood glucose in development of metabolic syndrome in rats

2021 ◽  
pp. 52-59
Author(s):  
Л.А. Ляпина ◽  
Н.Ф. Мясоедов ◽  
Т.А. Шубина ◽  
Л.А. Андреева ◽  
Т.Ю. Оберган ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Acetylsalicylic Acid ◽  
Prothrombin Time ◽  
Carbohydrate Metabolism ◽  
Intragastric Administration ◽  
Calorie Diet ◽  
Time Test ◽  
High Calorie Diet ◽  
High Calorie

Введение. Препараты разной структуры - углеводной, пептидной, белковой оказывают значительный противосвертывающий эффект в кровотоке с одновременным улучшением углеводного обмена. Цель - изучение в сравнительном аспекте влияния препаратов разной структуры (пептида, производного диоксикумарина и ацетилсалициловой кислоты -АСК) на свертывание крови, изменение углеводного обмена при интрагастральном способе их введении крысам. Методика. Использовались стандартные коагулологические методы и способы определения уровня глюкозы крови крыс. Каждый из препаратов (пептид Lys-Arg-Arg-Lys-Pro-Gly-Pro, варфарин и АСК) вводили лабораторным крысам Wistar интрагастрально в эффективной дозе (100 мкг/кг - пептид и варфарин и 1 мг/кг - АСК) в течение 7 сут на фоне развития метаболического синдрома, индуцируемого высококалорийной диетой (ВКД). Определения производили через 20 и 168 ч после последнего введения препаратов при продолжающемся постоянном кормлении крыс ВКД. Результаты. Установлено, что как через 20 ч, так и через 168 ч после последнего введения пептида и АСК агрегация тромбоцитов имела тенденцию к снижению и составляла 72-76% (через 20 ч) и 81-66,7% (через 168 ч); фибринолиз статистически значимо повышался при действии пептида на 61-180%, АСК - на 15-41%, варфарина - на 14-34%; активированное частичное тромбопластиновое время значимо удлинялось под влиянием пептида и варфарина на 24-52 и 31-52% соответственно; свертывание крови по тесту протромбинового времени снижалось только под влиянием варфарина (на 12.3%); уровень глюкозы крови нормализовался под влиянием всех использованых препаратов и составлял 4,9-6,5 ммоль/л против 8.1-8.8 ммоль/л при метаболическом синдроме. Заключение. При сравнении действия пептида, варфарина и АСК установлены гипокоагуляционные и гипогликемические эффекты в разной степени. Максимальным антикоагулянтным и фибринолитическим действием обладал пептид; варфарин проявлял антикоагулянтное действие только по тесту протромбиновое время, ацетилсалициловая кислота обладала антитромбоцитарным и фибриндеполимеризационным действием. Drugs with different structure, carbohydrates, peptides, and proteins, can produce a significant anticoagulation effect and simultaneously improve carbohydrate metabolism. The aim of this study was to compare effects of drugs with different structure, a peptide, a dioxicoumarin derivative, and acetylsalicylic acid (ASA), on coagulation and changes of carbohydrate metabolism in intragastric administration to rats. Methods. Standard methods for studying coagulation and measuring blood glucose in rats were used. Each of the study drugs (Lys-Arg-Arg-Lys-Pro-Gly-Pro peptide, warfarin, and ASA) was administered to Wistar rats intragastrically at an effective dose (100 mcg/kg for the peptide and warfarin and 1 mg/kg for ASA) for 7 days during the development of metabolic syndrome (MS) induced by a high-calorie diet (HCD). Measurements were performed at 20 and 168 h after the last administration of the drugs with continuing HCD. Results. Both at 20 and 168 h after the last administration of the peptide and ASA, platelet aggregation showed a tendency to a decrease and was 72-76% (at 20 h) and 81-66.7% (at 168 h); fibrinolysis significantly increased under the action of the peptide, ASA, and warfarin by 61-180%, 15-41%, and 14-34%, respectively. Activated partial thromboplastin time significantly increased under the action of the peptide and warfarin by 24-52% and 31-52%, respectively; blood clotting as estimated in the prothrombin time test decreased only under the action of warfarin by 12.3%; blood glucose returned to a normal level under the action of each of the three study drugs and was 4.9-6.5 mmol/l vs. 8.1-8.8 mmol/l in MS. Conclusion. The peptide, warfarin, and ASA produced different degrees of the anticoagulation and hypoglycemic effects. The peptide had the strongest anticoagulation and fibrinolytic effects, warfarin produced an anticoagulant effect only according to the prothrombin time test, and acetylsalicylic acid exerted both antiplatelet and fibrin-depolymerizing effects.

scholarly journals MORPHOMETRIC, INSTRUMENTAL AND LABORATORY PARAMETERS OF FEMALE RATS WITH EXPERIMENTAL METABOLIC SYNDROME

2020 ◽  
pp. 20-25
Author(s):  
O. A. Hrygorieva ◽  
Y. V. Korotchuk
Keyword(s):  
Metabolic Syndrome ◽  
Water Regime ◽  
Female Rats ◽  
Control Group ◽  
Laboratory Parameters ◽  
The Metabolic Syndrome ◽  
Calorie Diet ◽  
Experimental Group ◽  
High Calorie Diet ◽  
High Calorie

The aim of the study – to learn the dynamics of changes of morphometric, instrumental and laboratory parameters in mature females rats with experimental metabolic syndrome. Material and Methods. 20 females of white, mature laboratory rats, aged 18–20 months were divided into 2 groups. The first one is an experimental group: 13 female rats with experimental metabolic syndrome; the second one  – control group: 7 intact rats, with standard food and water regime. When working with animals, the standards of the Council of Europe Bioethics Convention 1997, the European Convention for the Protection of Vertebrate Animals were observed. Instruments used during scientific research were subject to metrological control. The simulation of the metabolic syndrome occurred during 60 days. The females supported a special high-calorie diet (grain with margarine 82 % milk fat, corn and sunflower seeds). The water regime included a 20 % solution of fructose and regular water ad libitum, with change every other day. Also, during the first and the fourth weeks of the experiment, the female daily subcutaneously administered Dexamethasone solution at a dosage of 0.1 mg/kg. Results. Since the beginning of the experiment, female rats who received a special high-calorie diet showed a statistically significant increase in all morphometric and instrumental indexes compared to similar rats in the control group. An increase in body weight in the experimental group was found to be 28.93 % higher than the original weight, was observed arterial hypertension (141/85±5) mmHg, dyslipidemia: elevated total cholesterol (5.37±0.33) mmol/L and TG (2.55±0.24) mmol/L; elevated level glucose (8.52±0.17) mmol/L. The above indicators are criteria indicating the presence of metabolic syndrome in animals under study. Conclusions. The proposed model of experimental metabolic syndrome, which includes subcutaneous administration of Dexamethasone solution at a dosage of 0.1 mg/kg in the first and the fourth weeks of experiment, with a special high calorie diet and a 20 % solution of fructose, is an effective way to reproduce the metabolic syndrome in small rodents.

scholarly journals Expediency of application of animals with the spontaneous hypertensia for modelling of the metabolic syndrome

2012 ◽  
Vol 10 (4) ◽  
pp. 91-94
Author(s):  
Maria Alexandrovna Kovaleva ◽  
Marina Nikolayevna Makarova ◽  
A. I. Selezneva ◽  
Valeriy Gennadyevich Makarov
Keyword(s):  
Metabolic Syndrome ◽  
Visceral Obesity ◽  
Cafeteria Diet ◽  
Blood Concentrations ◽  
Spontaneously Hypertensive ◽  
The Metabolic Syndrome ◽  
Calorie Diet ◽  
Wistar Kyoto ◽  
High Calorie Diet ◽  
High Calorie

When used within 11 weeks of diet “cafeteria diet” in spontaneously-hypertensive animals could lead to an increase in systolic blood pressure by 9%, sustained hyperglycemia, increased blood concentrations of triglycerides and cholesterol, as well as an increase in the relative content of visceral fat. In normotensive animals line Wistar-Kyoto prolonged use of “cafeteria diet” was accompanied only by an increase in blood glucose, cholesterol and triglycerides. Thus, the spontaneously hypertensive animals, the application of high-calorie diet demonstrated by three criteria pathogenesis of the metabolic syndrome: hyperglycemia, hypertension and visceral obesity, which allows you to use the model for the study of drugs aimed at treatment of metabolic syndrome.

The evaluation of lipid peroxidation and oxidative modification of proteins in blood serum under obesity development and the consumption of aqueous kidney beans Phaseolus vulgaris pods extract

2020 ◽  
Vol 33 (1) ◽  
pp. 38-44
Author(s):  
Alona Yurchenko ◽  
Daryna Krenytska ◽  
Olexii Savchuk ◽  
Tetiana Halenova ◽  
Natalia Raksha ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Oxidative Modification ◽  
Resistance Development ◽  
Oxidative Modification Of Proteins ◽  
Kidney Beans ◽  
Calorie Diet ◽  
Diet Control ◽  
High Calorie Diet ◽  
High Calorie

AbstractOur interest has focused on the investigation of the anti-obese potential of kidney beans (P. vulgaris) pods extract. In the course of the study, obesity development in rats was induced with high-calorie diet. Control and obese rats then have consumed with aqueous kidney beans (P. vulgaris) pods extract during 6 weeks (200 mg/kg). Results show that the long-term consumption of P. vulgaris pods extract can lead to the reduction of hyperglycemia and insulin resistance development. Furthermore, we saw a normalization of lipid peroxidation parameters and oxidative modification of protein due to the consumption of the kidney beans (P. vulgaris) pods extract. Our experimental data demonstrate the ability of the kidney beans (P. vulgaris) pod extracts to mitigate obesity development but the details of this mechanism remains to be not fully understood.

scholarly journals The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation, and Oxidative Stress Parameters and Fecal Microbiota in Patients with Depression Depending on Metabolic Syndrome Comorbidity—PRO-DEMET Randomized Study Protocol

2021 ◽  
Vol 10 (7) ◽  
pp. 1342
Author(s):  
Oliwia Gawlik-Kotelnicka ◽  
Anna Skowrońska ◽  
Aleksandra Margulska ◽  
Karolina H. Czarnecka-Chrebelska ◽  
Igor Łoniewski ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Study Protocol ◽  
Bifidobacterium Longum ◽  
White Blood Cells ◽  
Fecal Microbiota ◽  
Probiotic Supplementation ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

There is a huge need to search for new treatment options and potential biomarkers of therapeutic response to antidepressant treatment. Depression and metabolic syndrome often coexist, while a pathophysiological overlap, including microbiota changes, may play a role. The paper presents a study protocol that aims to assess the effect of probiotic supplementation on symptoms of depression, anxiety and stress, metabolic parameters, inflammatory and oxidative stress markers, as well as fecal microbiota in adult patients with depressive disorders depending on the co-occurrence of metabolic syndrome. The trial will be a four-arm, parallel-group, prospective, randomized, double-blind, controlled design that will include 200 participants and will last 20 weeks (ClinicalTrials.gov identifier: NCT04756544). The probiotic preparation will contain Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-175. We will assess the level of depression, anxiety and stress, quality of life, blood pressure, body mass index and waist circumference, white blood cells count, serum levels of C-reactive protein, high-density lipoprotein (HDL) cholesterol, triglycerides, fasting glucose, fecal microbiota composition and the level of some fecal microbiota metabolites, as well as serum inflammatory markers and oxidative stress parameters. The proposed trial may establish a safe and easy-to-use adjunctive treatment option in a subpopulation of depressive patients only partially responsive to pharmacologic therapy.

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