scholarly journals Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet/STZ-Induced Diabetic Rats

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 558 ◽  
Author(s):  
Jun-bo Wang ◽  
Xin-ran Liu ◽  
Si-qi Liu ◽  
Rui-xue Mao ◽  
Chao Hou ◽  
...  
Keyword(s):  
Body Weight ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Urine Volume ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Sd Rats ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

The study was aimed to determine whether treatment with oat oligopeptides (OOPs) could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in Sprague–Dawley (SD) rats. Diabetic SD rats modeling by a joint effect of high-calorie diet for 45 days and twice intraperitoneal injection of 30 mg/kg streptozotocin at one-week interval were observed with or without OOPs administration (0.25, 0.50, 1.00, and 2.00 g/kg Body Weight) for 12 weeks. Fasting blood glucose (FBG), oral glucose test tolerance (OGTT), serum insulin, level of antioxidant, and hepatic enzymes were measured. In addition, frequency of micturition was recorded in this study for the first time. It was observed that the administration of OOPs (2.00 g/kg Body Weight) resulted in a significant decrease (p < 0.05) in FBG since 6th week and a significant decrease (p < 0.05) in the OGTT-AUC on 6th and 10th week. In addition, the administration of OOPs (2.00 g/kg Body Weight) reduced HOMA-IR index and 24-h urine volume significantly (p < 0.05) whereas increased SOD activity significantly (p < 0.05). These results suggested that OOPs may have a hypoglycemic effect in diabetic rats.

scholarly journals Antidiabetic potential of the leaf extract of Centella asiatica in alloxaninduced diabetic rats

2016 ◽  
Vol 4 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Talha Bin Emran ◽  
Mycal Dutta ◽  
Mir Muhammad Nasir Uddin ◽  
Aninda Kumar Nath ◽  
Md Zia Uddin
Keyword(s):  
Body Weight ◽  
Leaf Extract ◽  
Total Cholesterol Level ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Centella Asiatica ◽  
Liver Glycogen ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Diabetic Rat

The study was designed to evaluate the glucose and cholesterol lowering effect of the aqueous extract of Centella asiatica leaf using the alloxan-induced diabetic rats and compared the activity with diabetic control and antidiabetic drug (Glibenclamide). Leaf extract (50 mg/kg) of C. asiatica and Glibenclamide were administered to normal and experimental diabetic rats for the duration of 10 days. In the alloxan-induced diabetic rat model, C. asiatica extract (50 mg/kg) significantly (p < 0.05) lowered the fasting blood glucose level as well as the total cholesterol level. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight, serum lipid profiles and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results (p < 0.05) were observed in the estimated parameters. Surprisingly, body weight was increased significantly (p < 0.05) in the C. asiatica treated diabetic group. Phytochemical screening showed the presence of alkaloids, flavonoids, glycosides, steroids and tannins in significant amountsJahangirnagar University J. Biol. Sci. 4(1): 51-59, 2015 (June)

scholarly journals Body Weight Impact on Puberty: Effects of High-Calorie Diet on Puberty Onset in Female Rhesus Monkeys

Endocrinology ◽  
2012 ◽  
Vol 153 (4) ◽  
pp. 1696-1705 ◽  
Author(s):  
Ei Terasawa ◽  
Joseph R. Kurian ◽  
Kim L. Keen ◽  
Nicholas A. Shiel ◽  
Ricki J. Colman ◽  
...  
Keyword(s):  
Body Weight ◽  
Rhesus Monkeys ◽  
Close Monitoring ◽  
Primate Research ◽  
Genetic Traits ◽  
Female Rhesus ◽  
Calorie Diet ◽  
Puberty Onset ◽  
High Calorie Diet ◽  
High Calorie

Secular trends toward a declining age at puberty onset with correlated changes in body weight have been reported in economically advanced countries. This has been attributed to excess calorie intake along with reduced physical activity in children. However, because the timing of puberty in humans is also influenced by other factors, such as genetic traits, living conditions, geographical location, and environmental chemicals, it is difficult to distinguish the effect of diet and body size from other factors in a human population. Here we report that feeding juvenile female rhesus monkeys born and raised at the Wisconsin National Primate Research Center with a high-calorie diet results in acceleration of body growth and precocious menarche. The monkeys fed a high-calorie diet also had an elevated body mass index. The most significant treatment effects on circulating hormones were increased leptin and IGF-I levels throughout the experiment. The findings of this study suggest the importance of close monitoring of juvenile feeding behaviors as an important intervention to reduce the prevalence of precocious development and metabolic diseases in adulthood.

scholarly journals Infrared spectral markers for the nephroprotective effects of Ficus deltoidea in streptozotocin-induced diabetic rats

2020 ◽  
Author(s):  
Nurdiana Samsulrizal ◽  
Goh Yong-Meng ◽  
Hafandi Ahmad ◽  
Nur Syimal’ain Azmi ◽  
Noor Syaffinaz Noor Mohamad Zin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Kidney Tissue ◽  
Diabetic Rats ◽  
Ficus Deltoidea ◽  
Analytical Technique ◽  
Infrared Spectral ◽  
Clustering Pattern

AbstractFourier Transform Infrared (FTIR) is an established analytical technique to elucidate new discriminatory biomarkers. Our previous study showed that Ficus deltoidea (Ficus: Moraceae) is capable of increasing insulin secretion and improving tissue regeneration by reducing oxidative stress in diabetic rats. However, the assessment of treatment response is limited by the paucity of biomarkers. We aimed to evaluate the potential use of FTIR for assessing the nephroprotective effects of Ficus deltoidea (Ficus: Moraceae) in diabetic rats. A rat model of diabetes was induced using a single intraperitoneal injection of streptozotocin (STZ) (60 mg/kg body weight). Methanolic extract of F. deltoidea was administered orally at a dose of 1000 mg/kg body weight for eight weeks. Fasting blood glucose, serum insulin and kidney function parameters were examined. The kidneys were subsequently subjected to FTIR and histological analyses. Enzyme-linked immunosorbent assays (ELISA) assessed the levels of oxidative stress, antioxidant, and apoptosis-related proteins in the kidney tissue. The results show, for the first time, that there is a good agreement between changes in kidney and FTIR peaks. The IR peaks (1545 cm−1 and 1511 cm-1) corresponding to amide II were restored by treatment with F. deltoidea. Multivariate analysis demonstrated that the diabetic rats treated with F. deltoidea had similar clustering pattern that of the normal animals. Biochemical and histological examination further confirmed the nephroprotective effect of F. deltoidea. Thus, demonstrating how FTIR spectroscopy could be used for the diagnosis of diabetes kidney disease.

scholarly journals THE INFLUENCE OF KIDNEY BEANS ( PHASEOLUS VULGARIS ) PODS EXTRACT ON OBESITY DEVELOPMENT

2016 ◽  
Vol 72 (2) ◽  
pp. 86-88
Author(s):  
A. Yurchenko ◽  
N. Raksha ◽  
O. Savchuk
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Food Intake ◽  
Phaseolus Vulgaris ◽  
Body Mass ◽  
Diet Group ◽  
Kidney Beans ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
High Calorie

The influence of kidney beans pods extract on obesity development was investigated. It was found that administration of P. vulgaris pods extract led to decrease of body weight and body mass index of the animals which were on high-calorie diet. Found changes could be result of decrease of food intake by rats treated with extract in compare with rats in high-calorie diet group.

scholarly journals Protective Effect of Free and Bound Polyphenol Extracts from Ginger (Zingiber officinaleRoscoe) on the Hepatic Antioxidant and Some Carbohydrate Metabolizing Enzymes of Streptozotocin-Induced Diabetic Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Mutiu Idowu Kazeem ◽  
Musbau Adewunmi Akanji ◽  
Musa Toyin Yakubu ◽  
Anofi Omotayo Tom Ashafa
Keyword(s):  
Body Weight ◽  
Antioxidant Enzymes ◽  
Liver Function ◽  
Fasting Blood Glucose ◽  
Zingiber Officinale ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Metabolizing Enzymes ◽  
Antioxidant Enzymes Activities

This study investigated the hepatoprotective effects of polyphenols fromZingiber officinaleon streptozotocin-induced diabetic rats by assessing liver antioxidant enzymes, carbohydrate-metabolizing enzymes and liver function indices. Initial oral glucose tolerance test was conducted using 125 mg/kg, 250 mg/kg, and 500 mg/kg body weight of both free and bound polyphenols fromZ. officinale. 28 day daily oral administration of 500 mg/kg body weight of free and bound polyphenols fromZ. officinaleto streptozotocin-induced (50 mg/kg) diabetic rats significantly reduced (P<0.05) the fasting blood glucose compared to control groups. There was significant increase (P<0.05) in the antioxidant enzymes activities in the animals treated with both polyphenols. Similarly, the polyphenols normalised the activities of some carbohydrate metabolic enzymes (hexokinase and phosphofructokinase) in the liver of the rats treated with it and significantly reduced (P<0.05) the activities of liver function enzymes. The results from the present study have shown that both free and bound polyphenols fromZ. officinaleespecially the free polyphenol could ameliorate liver disorders caused by diabetes mellitus in rats. This further validates the use of this species as medicinal herb and spice by the larger population of Nigerians.

scholarly journals Effects of Papaya Seed Oil (Carica papaya Linn.) on Food Consumption, Weight Gain and Hormones of Animals Treated With a High Calorie Diet

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1245-1245
Author(s):  
Lidiani Santana ◽  
Diana Aquino ◽  
Bruna Espirito Santo ◽  
Adriana Guércio ◽  
Mariana Tatara ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Consumption ◽  
Seed Oil ◽  
Saline Treatment ◽  
Calorie Diet ◽  
Hypercaloric Diet ◽  
High Calorie Diet ◽  
Papaya Seed ◽  
High Calorie

Abstract Objectives To evaluate the effects of papaya seed oil (Carica papaya Linn.) on food consumption, weight gain and hormonal of animals treated with a high calorie diet. Methods The project was approved by protocol no980/2018 (CEUA). Swiss, male, adult mice were used and divided into the experimental groups: control group (CT - Nuvital® diet - saline treatment), AIN-93M group (AIN-93M diet - saline treatment), HPL group (hypercaloric diet - saline treatment), HPL OS group (hypercaloric diet - soybean oil treatment), HPL AZ group (hypercaloric diet - olive oil treatment) and HPL OM group (hypercaloric diet - papaya seed oil treatment). The animals received treatment daily by gavage, 1 mL/kg, for 8 weeks. Body weight and food consumption were evaluated (Camry® analytical digital scale). At the end of the experiment, the animals were submitted to euthanasia and the blood was collected for quantification of leptin, insulin and resistin (commercial kit MADKMAG-71K®-Merck). The results were expressed as mean ± standard deviation, using Prisma 5.0 software (GraphPad Software, USA) (P ≤ 0.05).It was observed that the papaya seed oil reduced food consumption and body weight, as well as increased the concentration of leptin, maintaining insulin and resistin, thus being effective in combating the metabolic changes caused by the high fat diet. Results In the first month of the study, food consumption was lower in the HPL AZ and HPL OM groups than in the CT (P &lt; 0.005), and in the second month all groups that received HPL diet consumed less if compared to the CT, being that HPL OM have significantly lower consumption than groups AIN-93M, CT and HPL (P &lt; 0.05). At the beginning of the experiment, all animals were weighed and evenly distributed in the groups (P = 0.938). In the first and second weeks, HLP OM had a lower weight than HLP OS and HPL (P &lt; 0.05). In the weeks that followed, the weight gain of the HLP OM group was lower compared to the groups that received a high-fat diet, but without significant difference. In the evaluation of the hormone leptin, a higher value was found in the HPL OM group (P &lt; 0.001), with values of resistin and insulin similar to the control groups. Conclusions It was observed that the papaya seed oil reduced food consumption and body weight, as well as increased the concentration of leptin, maintaining insulin and resistin. Funding Sources CNPQ.

scholarly journals ANTIDIABETIC EFFECT OF THYMUS SATUREIOIDES AQUEOUS EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

2016 ◽  
Vol 8 (9) ◽  
pp. 140 ◽  
Author(s):  
Mohamed El Kabbaoui ◽  
Alae Chda ◽  
Najlae Mejrhit ◽  
Abdellah Farah ◽  
Lotfi Aarab ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Aqueous Extract ◽  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Aerial Parts ◽  
Thymus Satureioides

<p><strong>Objective</strong>:<strong> </strong>The aerial parts of <em>Thymus satureioides </em>have been traditionally used to treat diabetes mellitus and its complications in Morocco. The aim of the present study was to investigate the antidiabetic and antihyperlipidemic effects of the aqueous extract of <em>Thymus satureioides </em>aerial parts in streptozotocin (STZ) induced diabetic rats.</p><p><strong>Methods: </strong>Experimental diabetes was induced in overnight fasted rats by intraperitoneal injection of streptozotocin (45 mg/kg). Diabetic rats were orally administered with aqueous extract of <em>Thymus satureioides</em> (500 mg/kg b.w.) for 28 d. Glibenclamide (2 mg/kg), a standard antidiabetic drug, was used as a positive control drug. Body weight and fasting blood glucose (FGB) were measured every week. Oral glucose tolerance, change in lipid parameters, urea, creatinine, aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) levels of diabetic rats were evaluated at the end of the treatment.</p><p><strong>Results: </strong>Administration of <em>Thymus satureioides </em>aqueous extract to diabetic rats for 28 d reduced their fasting blood glucose levels significantly compared to the diabetic control rats. The extract improved body weight and glucose tolerance in diabetic rats. The antihyperlipidemic assessment of the extract revealed a decrease in plasma total cholesterol, triglycerides, LDL levels and an increase in HDL level in the plasma of treated diabetic rats. Furthermore, the biochemical liver and kidney functional tests have shown that serum biomarkers of liver and renal dysfunction were significantly reduced in treated diabetic rats.</p><strong>Conclusion: </strong>The present findings suggest that <em>Thymus satureioides </em>extract has both antidiabetic and antihyperlipidemic effects in experimental diabetic rats which can be beneficial in the management of diabetes and its complications.<p> </p>

scholarly journals Altered Lipid Responses to Dietary Interventions in Obesity

2015 ◽  
Vol 3 (1) ◽  
pp. 01-11
Author(s):  
Meena Godhia ◽  
Nagma Naik
Keyword(s):  
Vitamin D ◽  
Body Weight ◽  
Hematological Parameters ◽  
Fasting Blood Glucose ◽  
Vitamin D Supplementation ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Oral Glucose ◽  
Hematological Analysis ◽  
Glycemic Profile

Results obtained from studies on the effect of vitamin D supplementation with or without calcium on glucose homeostasis and hematological parameters have been inconsistent. This experimentally-controlled designed study investigated the combined effects of Ca2+ and Vit.D-fortified diet on body weight, glycemic profile, biochemical, haemostatic and haematological parameters in 2 groups (n=8, each) of experimental male diabetic and healthy albino rats following treatment with Ca2+ and Vit.D-fortified diet for 6 weeks. 2 similar groups of rats (n=8, each) on normal diets served as normal and diabetic controls respectively to allow comparison between groups. Induction of diabetes (100mg/dL, intraperitoneally) was achieved with freshly prepared alloxan monohydrate solution after 15 hours overnight fast while oral glucose tolerance test, biochemical and hematological analysis were performed on blood samples. Fasting blood glucose (FBG) was taken at study baseline and 6 weeks after feeding. Mean weights were significantly (p < 0.05) lower in calcium/vitamin D-fortifed diet-fed diabetic and normal rats compared with their respective controls. Actual percentage numerical weight gain at 6 weeks of study includes: diabetic rats on treatment diet (15.50%); diabetic controlled rats (18.70%); normal rats on treatment diet (20.40%); normal controlled rats (25.10%). At 6 weeks of study, experimental diabetic rats showed significant (p < 0.05) reduction (22.83%) in mean FBG concentration compared with the diabetic control rats. Experimental rats fed on calcium and vitamin D-fortified diet displayed improved glycemic tolerance over their respective controls. Hematological analysis revealed insignificant (p > 0.05) difference in hematological and hemostatic indices between the experimental and controlled rats. In diabetic rats, Ca2+ and Vit.D-fortified diet reduced body weight with beneficial hypoglycemic and remarkable glycemic tolerant effects on glycemic profile without significant impact on hemostatic and hematological indices.

scholarly journals Differential impact of maternal overnutrition and undernutrition on offspring glucose homeostasis

2020 ◽  
Author(s):  
Praise B. Adekunbi ◽  
Abimbola O. Ogunsola ◽  
Daniel A. Adekunbi
Keyword(s):  
Blood Glucose ◽  
Birth Weight ◽  
Fasting Blood Glucose ◽  
Female Offspring ◽  
Male Offspring ◽  
Maternal Undernutrition ◽  
Calorie Diet ◽  
Maternal Overnutrition ◽  
High Calorie Diet ◽  
High Calorie

AbstractTo test the hypothesis that maternal undernutrition exerts a greater effect on offspring metabolic function compared to maternal overnutrition, female rats (n=10 per group) were subjected to a high calorie diet or 50 % global nutrient restriction relative to control rats on standard rat chow, for 8 weeks prior to pregnancy and during pregnancy. Birth weight was determined on the day dams were found with pups. At 3 months of age, offspring’s fasting blood glucose, serum insulin and triglyceride levels as well as glucose tolerance and insulin sensitivity were determined. A 50 % calorie restriction caused a significant weight loss in the under-nourished dams but those on high calorie diet had similar body weight as control rats. Maternal overnutrition and undernutrition significantly lowered birth weight, indicating intra-uterine growth restriction in these animals. Fasting blood glucose was significantly higher in female offspring of over-nourished dams, but neither maternal overnutrition nor undernutrition affected offspring’s glucose tolerance. Male offspring of dams exposed to maternal overnutrition or undernutrition had a significantly higher insulin level compared to control, whereas female offspring were unaffected. The development of hyperinsulinaemia in male offspring of undernourished dams was accompanied by reduced insulin sensitivity. This study demonstrates that early-life exposure to two extreme ends of the nutritional plane is associated with similar birth weight outcome but different metabolic phenotype in adulthood. Evidence of insulin resistance only in male offspring of under-nourished dams indicates differences in sex-specific metabolic effect of maternal undernutrition compared to overnutrition.

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