scholarly journals Ascorbic Acid Transported by Sodium-Dependent Vitamin C Transporter 2 Stimulates Steroidogenesis in Human Choriocarcinoma Cells

Endocrinology ◽  
2008 ◽  
Vol 149 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Ximei Wu ◽  
Takuma Iguchi ◽  
Norio Itoh ◽  
Kousuke Okamoto ◽  
Tatsuya Takagi ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Sodium Dependent ◽  
Choriocarcinoma Cells ◽  
Human Choriocarcinoma Cells

Sodium-dependent vitamin C transporter 2 (SVCT2) is necessary for the uptake of L-ascorbic acid into Schwann cells

Glia ◽  
2009 ◽  
pp. NA-NA ◽  
Author(s):  
Burkhard Gess ◽  
Christina Lohmann ◽  
Hartmut Halfter ◽  
Peter Young
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Schwann Cells ◽  
Sodium Dependent

Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid

2007 ◽  
Vol 575 (1-3) ◽  
pp. 1-11 ◽  
Author(s):  
Takeshi Takarada ◽  
Eiichi Hinoi ◽  
Yuki Kambe ◽  
Koichi Sahara ◽  
Shintaro Kurokawa ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Sodium Dependent

Cellular and intracellular transport of vitamin C. The physiologic aspects

2013 ◽  
Vol 154 (42) ◽  
pp. 1651-1656 ◽  
Author(s):  
András Szarka ◽  
Tamás Lőrincz
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Intracellular Transport ◽  
Initial Rate ◽  
Plasma Concentrations ◽  
Dehydroascorbic Acid ◽  
Reduced Form ◽  
Human Diet ◽  
Sodium Dependent ◽  
The One

Vitamin C requirement is satisfied by natural sources and vitamin C supplements in the ordinary human diet. The two major forms of vitamin C in the diet are L-ascorbic acid and L-dehydroascorbic acid. Both ascorbate and dehydroascorbate are absorbed along the entire length of the human intestine. The reduced form, L-ascorbic acid is imported by an active mechanism, requiring two sodium-dependent vitamin C transporters (SVCT1 and SVCT2). The transport of the oxidized form, dehydroascorbate is mediated by glucose transporters GLUT1, GLUT3 and possibly GLUT4. Initial rate of uptake of both ascorbate and dehydroascorbate is saturable with increasing external substrate concentration. Vitamin C plasma concentrations are tightly controlled when the vitamin is taken orally. It has two simple reasons, on the one hand, the capacity of the transporters is limited, on the other hand the two Na+-dependent transporters can be down-regulated by an elevated level of ascorbate. Orv. Hetil., 154 (42), 1651–1656.

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