Ascorbic Acid and Sodium-Dependent Vitamin C Transporters in the Peripheral Nervous System: From Basic Science to Clinical Trials

2013 ◽  
Vol 19 (17) ◽  
pp. 2105-2114 ◽  
Author(s):  
Burkhard Gess ◽  
Dominik Röhr ◽  
Peter Young
Keyword(s):  
Clinical Trials ◽  
Ascorbic Acid ◽  
Nervous System ◽  
Vitamin C ◽  
Peripheral Nervous System ◽  
Basic Science ◽  
Sodium Dependent

Effect of Vitamin C on Plasma Lipids

1995 ◽  
Vol 29 (11) ◽  
pp. 1129-1136 ◽  
Author(s):  
Patricia A Howard ◽  
David G Meyers
Keyword(s):  
Clinical Trials ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
English Language ◽  
Plasma Lipids ◽  
Antioxidant Properties ◽  
Plasma Lipid ◽  
High Density Lipoproteins ◽  
Medline Search ◽  
Review Articles

Objective: To review the effects of vitamin C (ascorbic acid) on plasma lipid concentrations, and to address the proposed mechanisms through which vitamin C may potentially alter lipid concentrations. Data Source: A MEDLINE search was performed to identify pertinent English-language literature including studies, abstracts, and review articles. Key search terms were vitamin C, ascorbic acid, lipoproteins, lipids, and atherosclerosis. Study Selection and Data Extraction: Studies examining the relationships between vitamin C and plasma lipid concentrations including animal, observational, and clinical trials were selected. Because there were no large randomized, controlled clinical trials, data were extracted from all clinical trials, regardless of design. Review articles discussing the effects of vitamin C on plasma lipid concentrations and the atherosclerotic process also were included. Pertinent information, as judged by the authors, was extracted for discussion. Data Synthesis: Evidence suggests an inverse relationship between vitamin C intake and the development of atherosclerosis, although the effect has not yet been proven in clinical trials. It has been postulated that this effect might be mediated not only through the antioxidant properties of vitamin C, but also through a plasma lipid-modifying effect. Data from animal and observational trials suggest that high vitamin C concentrations may correlate negatively with concentrations of total cholesterol, triglycerides, and low-density lipoproteins and positively with high-density lipoproteins. Other studies, however, have not confirmed these findings. Similarly, results from clinical trials have been widely variable and inconclusive. Conclusions: Analysis of the literature suggests an association between vitamin C and plasma lipid concentrations and a potential role in slowing the development of atherosclerosis. Significant variations and inadequacies in trial design, however, prohibit definitive conclusions. On the basis of these preliminary data, it appears that there is justification for additional well-designed trials to further evaluate the relationship between vitamin C and plasma lipid concentrations.

scholarly journals Ascorbic Acid Transported by Sodium-Dependent Vitamin C Transporter 2 Stimulates Steroidogenesis in Human Choriocarcinoma Cells

Endocrinology ◽  
2008 ◽  
Vol 149 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Ximei Wu ◽  
Takuma Iguchi ◽  
Norio Itoh ◽  
Kousuke Okamoto ◽  
Tatsuya Takagi ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Sodium Dependent ◽  
Choriocarcinoma Cells ◽  
Human Choriocarcinoma Cells

Sodium-dependent vitamin C transporter 2 (SVCT2) is necessary for the uptake of L-ascorbic acid into Schwann cells

Glia ◽  
2009 ◽  
pp. NA-NA ◽  
Author(s):  
Burkhard Gess ◽  
Christina Lohmann ◽  
Hartmut Halfter ◽  
Peter Young
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Schwann Cells ◽  
Sodium Dependent

Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid

2007 ◽  
Vol 575 (1-3) ◽  
pp. 1-11 ◽  
Author(s):  
Takeshi Takarada ◽  
Eiichi Hinoi ◽  
Yuki Kambe ◽  
Koichi Sahara ◽  
Shintaro Kurokawa ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Sodium Dependent

scholarly journals Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 553
Author(s):  
Maria Bogdan ◽  
Andreea Daniela Meca ◽  
Mihail Virgil Boldeanu ◽  
Dorin Nicolae Gheorghe ◽  
Adina Turcu-Stiolica ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Trials ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Periodontal Disease ◽  
Fruits And Vegetables ◽  
Water Soluble ◽  
Beneficial Effects ◽  
Positive Effects ◽  
Water Soluble Vitamin

Ascorbic acid (vitamin C) is an important water-soluble vitamin found in many fruits and vegetables. It has well-documented beneficial effects on the human body and is used as a supplement, alone or in combination with other vitamins and minerals. Over recent years, research has focused on possible new therapeutic actions in chronic conditions including periodontal disease (PD). We conducted a systematic review on clinical trials from four databases (PubMed, Clinical Trials, Cochrane, Web of Science) which measured plasmatic/salivary levels of ascorbic acid in PD–diabetes mellitus (DM) association. Six studies were included in our review, three of them analyzing patients with different grades of PD and DM who received vitamin C as a treatment (500 mg vitamin C/day for 2 months and 450 mg/day for 2 weeks) or as part of their alimentation (guava fruits), in combination with standard therapies and procedures. Decreased levels of vitamin C were observed in PD patients with DM but data about efficacy of vitamin C administration are inconclusive. Given the important bidirectional relationship between PD and DM, there is a strong need for more research to assess the positive effects of ascorbic acid supplementation in individuals suffering from both diseases and also its proper regimen for these patients.

scholarly journals Role of the Peripheral Nervous System in PD Pathology, Diagnosis, and Treatment

2021 ◽  
Vol 15 ◽  
Author(s):  
Chengxiao Ma ◽  
Wen Zhang ◽  
Maohong Cao
Keyword(s):  
Clinical Trials ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Animal Studies ◽  
Neuronal Damage ◽  
Motor Dysfunction ◽  
The Central Nervous System ◽  
Diagnostic Research ◽  
Non Motor Symptoms

Studies on Parkinson disease (PD) have mostly focused on the central nervous system—specifically, on the loss of mesencephalic dopaminergic neurons and associated motor dysfunction. However, the peripheral nervous system (PNS) is gaining prominence in PD research, with increasing clinical attention being paid to non-motor symptoms. Researchers found abnormal deposition of α-synuclein and neuroinflammation in the PNS. Attempts have been made to use these pathological changes during the clinical diagnosis of PD. Animal studies demonstrated that combined transplantation of autologous peripheral nerves and cells with tyrosine hydroxylase activity can reduce dopaminergic neuronal damage, and similar effects were observed in some clinical trials. In this review, we will systematically explain PNS performance in PD pathology and its clinical diagnostic research, describe PNS experimental results [especially Schwann cell (SC) transplantation in the treatment of PD animal models] and the results of clinical trials, and discuss future directions. The mechanism by which SCs produce such a therapeutic effect and the safety of transplantation therapy are briefly described.

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