Oxygen Sensitivity of Central Cardiorespiratory Regions

2003 ◽  
pp. 682-697
Keyword(s):  
Oxygen Sensitivity

scholarly journals Oxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 155
Author(s):  
Daniel Morales-Cano ◽  
Bianca Barreira ◽  
Beatriz De Olaiz Navarro ◽  
María Callejo ◽  
Gema Mondejar-Parreño ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Gas Exchange ◽  
Pulmonary Circulation ◽  
Pulmonary Arteries ◽  
Blood Perfusion ◽  
Mesenteric Arteries ◽  
Oxygen Sensitivity ◽  
Low Oxygen ◽  
Oxygen Selectivity

Current approved therapies for pulmonary hypertension (PH) aim to restore the balance between endothelial mediators in the pulmonary circulation. These drugs may exert vasodilator effects on poorly oxygenated vessels. This may lead to the derivation of blood perfusion towards low ventilated alveoli, i.e., producing ventilation-perfusion mismatch, with detrimental effects on gas exchange. The aim of this study is to analyze the oxygen-sensitivity in vitro of 25 drugs currently used or potentially useful for PH. Additionally, the study analyses the effectiveness of these vasodilators in the pulmonary vs. the systemic vessels. Vasodilator responses were recorded in pulmonary arteries (PA) and mesenteric arteries (MA) from rats and in human PA in a wire myograph under different oxygen concentrations. None of the studied drugs showed oxygen selectivity, being equally or more effective as vasodilators under conditions of low oxygen as compared to high oxygen levels. The drugs studied showed low pulmonary selectivity, being equally or more effective as vasodilators in systemic than in PA. A similar behavior was observed for the members within each drug family. In conclusion, none of the drugs showed optimal vasodilator profile, which may limit their therapeutic efficacy in PH.

Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia

2015 ◽  
Vol 75 (5) ◽  
pp. 2050-2054 ◽  
Author(s):  
Ronn P. Walvick ◽  
John P. Roche ◽  
Austin L. Reno ◽  
Matthew J. Gounis ◽  
Mitchell S. Albert
Keyword(s):  
Oxygen Sensitivity ◽  
Hyperpolarized Helium ◽  
Pulmonary Ischemia

The pore region of the Kv1.2α subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity

2003 ◽  
Vol 306 (2) ◽  
pp. 450-456 ◽  
Author(s):  
Laura Conforti ◽  
Koichi Takimoto ◽  
Milan Petrovic ◽  
Olaf Pongs ◽  
David Millhorn
Keyword(s):  
Oxygen Sensitivity ◽  
Pore Region

scholarly journals Post-transcriptional Control of Human maxiK Potassium Channel Activity and Acute Oxygen Sensitivity by Chronic Hypoxia

2003 ◽  
Vol 278 (51) ◽  
pp. 51422-51432 ◽  
Author(s):  
Matthew E. Hartness ◽  
Stephen P. Brazier ◽  
Chris Peers ◽  
Alan N. Bateson ◽  
Michael L. J. Ashford ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Transcriptional Control ◽  
Chronic Hypoxia ◽  
Oxygen Sensitivity ◽  
Channel Activity ◽  
Potassium Channel Activity

Hydrogen-Activating Enzymes: Activity Does Not Correlate with Oxygen Sensitivity

2008 ◽  
Vol 47 (11) ◽  
pp. 2052-2054 ◽  
Author(s):  
Carole Baffert ◽  
Marie Demuez ◽  
Laurent Cournac ◽  
Bénédicte Burlat ◽  
Bruno Guigliarelli ◽  
...  
Keyword(s):  
Oxygen Sensitivity ◽  
Enzymes Activity

scholarly journals XPS STUDIES OF CeO2/Nb2O5 INTERFACE EFFECT ON THE IMPROVEMENT OF THE OXYGEN SENSITIVITY OF CeO2 LAYER

1998 ◽  
Vol 47 (12) ◽  
pp. 2025
Author(s):  
DU XIN-HUA ◽  
LIU ZHEN-XIANG ◽  
XIE KAN ◽  
WANG YAN-BIN ◽  
CHU WU-YANG
Keyword(s):  
Interface Effect ◽  
Oxygen Sensitivity

Development of Algal Systems for Hydrogen Photoproduction: Addressing the Hydrogenase Oxygen-sensitivity Problem

2006 ◽  
pp. 211-227 ◽  
Author(s):  
Maria L. Ghirardi ◽  
Paul King ◽  
Sergey Kosourov ◽  
Marc Forestier ◽  
Liping Zhang ◽  
...  
Keyword(s):  
Oxygen Sensitivity ◽  
Hydrogen Photoproduction ◽  
Sensitivity Problem

Anaerobic Methods, Techniques and Principles for Food Bacteriology: A Review

1983 ◽  
Vol 46 (9) ◽  
pp. 811-822 ◽  
Author(s):  
KEVIN L. ANDERSON ◽  
DANIEL Y. C. FUNG
Keyword(s):  
Environmental Microbiology ◽  
Reducing Agents ◽  
Food Microbiology ◽  
Oxygen Sensitivity ◽  
Theoretical Concepts ◽  
Cultivation Systems ◽  
Early Stages ◽  
Modern Methods ◽  
Canning Industry ◽  
Modern Era

Anaerobic systems for cultivation of bacteria have been studied extensively in clinical and environmental microbiology. Such studies have not received much attention in food microbiology, except perhaps in the canning industry. This review summarizes the developments of anaerobic methodology from early stages to the modern era. Theories and principles behind modern methods are presented as well as a discussion of problems that may arise. Also theoretical concepts attributing to oxygen sensitivity of anaerobes and practical use of reducing agents in the cultivation of anaerobes are considered. The purpose of this review is to provide food microbiologists with some guidelines in use and development of anaerobic methodology and cultivation systems in bacteriology.

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