scholarly journals XPS STUDIES OF CeO2/Nb2O5 INTERFACE EFFECT ON THE IMPROVEMENT OF THE OXYGEN SENSITIVITY OF CeO2 LAYER

1998 ◽  
Vol 47 (12) ◽  
pp. 2025
Author(s):  
DU XIN-HUA ◽  
LIU ZHEN-XIANG ◽  
XIE KAN ◽  
WANG YAN-BIN ◽  
CHU WU-YANG
Keyword(s):  
Interface Effect ◽  
Oxygen Sensitivity

scholarly journals Oxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 155
Author(s):  
Daniel Morales-Cano ◽  
Bianca Barreira ◽  
Beatriz De Olaiz Navarro ◽  
María Callejo ◽  
Gema Mondejar-Parreño ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Gas Exchange ◽  
Pulmonary Circulation ◽  
Pulmonary Arteries ◽  
Blood Perfusion ◽  
Mesenteric Arteries ◽  
Oxygen Sensitivity ◽  
Low Oxygen ◽  
Oxygen Selectivity

Current approved therapies for pulmonary hypertension (PH) aim to restore the balance between endothelial mediators in the pulmonary circulation. These drugs may exert vasodilator effects on poorly oxygenated vessels. This may lead to the derivation of blood perfusion towards low ventilated alveoli, i.e., producing ventilation-perfusion mismatch, with detrimental effects on gas exchange. The aim of this study is to analyze the oxygen-sensitivity in vitro of 25 drugs currently used or potentially useful for PH. Additionally, the study analyses the effectiveness of these vasodilators in the pulmonary vs. the systemic vessels. Vasodilator responses were recorded in pulmonary arteries (PA) and mesenteric arteries (MA) from rats and in human PA in a wire myograph under different oxygen concentrations. None of the studied drugs showed oxygen selectivity, being equally or more effective as vasodilators under conditions of low oxygen as compared to high oxygen levels. The drugs studied showed low pulmonary selectivity, being equally or more effective as vasodilators in systemic than in PA. A similar behavior was observed for the members within each drug family. In conclusion, none of the drugs showed optimal vasodilator profile, which may limit their therapeutic efficacy in PH.

Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia

2015 ◽  
Vol 75 (5) ◽  
pp. 2050-2054 ◽  
Author(s):  
Ronn P. Walvick ◽  
John P. Roche ◽  
Austin L. Reno ◽  
Matthew J. Gounis ◽  
Mitchell S. Albert
Keyword(s):  
Oxygen Sensitivity ◽  
Hyperpolarized Helium ◽  
Pulmonary Ischemia

Interface effect of rare-earth metals gadolinium(Gd) and lanthanum(La)

1984 ◽  
Vol 2 (5) ◽  
pp. 373-376 ◽  
Author(s):  
S.Y. Li ◽  
T.J. Zhang ◽  
S.S. Li ◽  
Y.Z. Wang
Keyword(s):  
Rare Earth ◽  
Rare Earth Metals ◽  
Interface Effect
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