Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia

2015 ◽  
Vol 75 (5) ◽  
pp. 2050-2054 ◽  
Author(s):  
Ronn P. Walvick ◽  
John P. Roche ◽  
Austin L. Reno ◽  
Matthew J. Gounis ◽  
Mitchell S. Albert
Keyword(s):  
Oxygen Sensitivity ◽  
Hyperpolarized Helium ◽  
Pulmonary Ischemia

Measurement of Large Airways Using Dynamic 3D Hyperpolarized Helium-3 MR Imaging.

2009 ◽  
Author(s):  
ET Peterson ◽  
JH Holmes ◽  
A Dattawadkar ◽  
G Agrawal ◽  
J Dai ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Hyperpolarized Helium ◽  
Large Airways ◽  
Helium 3

scholarly journals Oxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 155
Author(s):  
Daniel Morales-Cano ◽  
Bianca Barreira ◽  
Beatriz De Olaiz Navarro ◽  
María Callejo ◽  
Gema Mondejar-Parreño ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Gas Exchange ◽  
Pulmonary Circulation ◽  
Pulmonary Arteries ◽  
Blood Perfusion ◽  
Mesenteric Arteries ◽  
Oxygen Sensitivity ◽  
Low Oxygen ◽  
Oxygen Selectivity

Current approved therapies for pulmonary hypertension (PH) aim to restore the balance between endothelial mediators in the pulmonary circulation. These drugs may exert vasodilator effects on poorly oxygenated vessels. This may lead to the derivation of blood perfusion towards low ventilated alveoli, i.e., producing ventilation-perfusion mismatch, with detrimental effects on gas exchange. The aim of this study is to analyze the oxygen-sensitivity in vitro of 25 drugs currently used or potentially useful for PH. Additionally, the study analyses the effectiveness of these vasodilators in the pulmonary vs. the systemic vessels. Vasodilator responses were recorded in pulmonary arteries (PA) and mesenteric arteries (MA) from rats and in human PA in a wire myograph under different oxygen concentrations. None of the studied drugs showed oxygen selectivity, being equally or more effective as vasodilators under conditions of low oxygen as compared to high oxygen levels. The drugs studied showed low pulmonary selectivity, being equally or more effective as vasodilators in systemic than in PA. A similar behavior was observed for the members within each drug family. In conclusion, none of the drugs showed optimal vasodilator profile, which may limit their therapeutic efficacy in PH.

scholarly journals Dynamic MRI of Grid-Tagged Hyperpolarized Helium-3 for the Assessment of Lung Motion During Breathing

2009 ◽  
Vol 75 (1) ◽  
pp. 276-284 ◽  
Author(s):  
Jing Cai ◽  
Ke Sheng ◽  
Stanley H. Benedict ◽  
Paul W. Read ◽  
James M. Larner ◽  
...  
Keyword(s):  
Dynamic Mri ◽  
Hyperpolarized Helium ◽  
Lung Motion ◽  
Helium 3

scholarly journals Feature analysis of hyperpolarized helium-3 pulmonary MRI: A study of asthmatics versus nonasthmatics

2010 ◽  
Vol 63 (6) ◽  
pp. 1448-1455 ◽  
Author(s):  
Nicholas J. Tustison ◽  
Talissa A. Altes ◽  
Gang Song ◽  
Eduard E. de Lange ◽  
John P. Mugler ◽  
...  
Keyword(s):  
Feature Analysis ◽  
Hyperpolarized Helium ◽  
Helium 3

The pore region of the Kv1.2α subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity

2003 ◽  
Vol 306 (2) ◽  
pp. 450-456 ◽  
Author(s):  
Laura Conforti ◽  
Koichi Takimoto ◽  
Milan Petrovic ◽  
Olaf Pongs ◽  
David Millhorn
Keyword(s):  
Oxygen Sensitivity ◽  
Pore Region

scholarly journals Pulmonary ischemia induces lung remodeling and angiogenesis

2006 ◽  
Vol 100 (2) ◽  
pp. 587-593 ◽  
Author(s):  
Elizabeth M. Wagner ◽  
Irina Petrache ◽  
Brian Schofield ◽  
Wayne Mitzner
Keyword(s):  
Left Lung ◽  
Lung Parenchyma ◽  
Left Pulmonary Artery ◽  
Nuclear Antigen ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Visceral Pleura ◽  
Artery Ligation ◽  
Dividing Cells ◽  
Apoptotic Activity ◽  
Pulmonary Ischemia

Cellular remodeling during angiogenesis in the lung is poorly described. Furthermore, it is the systemic vasculature of the lung and surrounding the lung that is proangiogenic when the pulmonary circulation becomes impaired. In a mouse model of chronic pulmonary thromboembolism, after left pulmonary artery ligation (LPAL), the intercostal vasculature, in proximity to the ischemic lung, proliferates and invades the lung ( 12 ). In the present study, we performed a detailed investigation of the kinetics of remodeling using histological sections of the left lung of C57Bl/6J mice after LPAL (4 h to 20 days) or after sham surgery. New vessels were seen within the thickened visceral pleura 4 days after LPAL predominantly in the upper portion of the left lung. Connections between new vessels within the pleura and pulmonary capillaries were clearly discerned by 7 days after LPAL. The visceral pleura and the lung parenchyma showed intense tissue remodeling, as evidenced by markedly elevated levels of both proliferating cell nuclear antigen and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling positive cells. Rapidly dividing cells were predominantly macrophages and type II pneumocytes. The increased apoptotic activity was further quantified by caspase-3 activity, which showed a sixfold increase relative to naive lungs, by 24 h after LPAL. Because sham surgeries had little effect on measured parameters, we conclude that both thoracic wound healing and pulmonary ischemia are required for systemic neovascularization.

scholarly journals Post-transcriptional Control of Human maxiK Potassium Channel Activity and Acute Oxygen Sensitivity by Chronic Hypoxia

2003 ◽  
Vol 278 (51) ◽  
pp. 51422-51432 ◽  
Author(s):  
Matthew E. Hartness ◽  
Stephen P. Brazier ◽  
Chris Peers ◽  
Alan N. Bateson ◽  
Michael L. J. Ashford ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Transcriptional Control ◽  
Chronic Hypoxia ◽  
Oxygen Sensitivity ◽  
Channel Activity ◽  
Potassium Channel Activity
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