New Light Through an Old Window? The “Translational Turn” in Biomedical Research: A Historical Perspective

2016 ◽  
pp. 33-68
1979 ◽  
Vol 9 (3) ◽  
pp. 203-237 ◽  
Author(s):  
Gerald J. Gruman

The ethical dilemmas surrounding dying and death today can be understood more adequately when placed in an historical perspective. The methodology of intellectual history is employed to examine the sequence of cultural stages from prehistory to the contemporary scene, using the concept of the death system (Kastenbaum) as an organizing formulation. It is suggested in conclusion that a modern version of the meliorist ethos can lend support to the on-going modes of biomedical research and the application of the activist therapeutic principle in medical practice. Humanity has labored and suffered too much to abandon hope at this time and either submerge the personality of the individual or turn to a nihilistic “death worship” (Borkenau).


2001 ◽  
Vol 43 (4) ◽  
pp. 209-212 ◽  
Author(s):  
Augusto SIMÕES-BARBOSA ◽  
Constança SIMÕES BARBOSA ◽  
Frederico SIMÕES BARBOSA

We all hope that biotechnology will answer some social and economical unavoidable requirements of the modern life. It is necessary to improve agriculture production, food abundance and health quality in a sustainable development. It is indeed a hard task to keep the progress on taking into account the rational use of genetic resources and the conservation of biodiversity. In this context, a historical perspective and prospects of the biomedical research on parasitic diseases is described in a view of three generations of investigators. This work begins with a picture of the scientific progress on biomedical research and human health over the last centuries. This black-and-white picture is painted by dissecting current advancements of molecular biology and modern genetics, which are outlined at the meaning of prospecting achievements in health science for this new millenium.


Author(s):  
T. L. Hayes

Biomedical applications of the scanning electron microscope (SEM) have increased in number quite rapidly over the last several years. Studies have been made of cells, whole mount tissue, sectioned tissue, particles, human chromosomes, microorganisms, dental enamel and skeletal material. Many of the advantages of using this instrument for such investigations come from its ability to produce images that are high in information content. Information about the chemical make-up of the specimen, its electrical properties and its three dimensional architecture all may be represented in such images. Since the biological system is distinctive in its chemistry and often spatially scaled to the resolving power of the SEM, these images are particularly useful in biomedical research.In any form of microscopy there are two parameters that together determine the usefulness of the image. One parameter is the size of the volume being studied or resolving power of the instrument and the other is the amount of information about this volume that is displayed in the image. Both parameters are important in describing the performance of a microscope. The light microscope image, for example, is rich in information content (chemical, spatial, living specimen, etc.) but is very limited in resolving power.


Author(s):  
R. W. Cole ◽  
J. C. Kim

In recent years, non-human primates have become indispensable as experimental animals in many fields of biomedical research. Pharmaceutical and related industries alone use about 2000,000 primates a year. Respiratory mite infestations in lungs of old world monkeys are of particular concern because the resulting tissue damage can directly effect experimental results, especially in those studies involving the cardiopulmonary system. There has been increasing documentation of primate parasitology in the past twenty years.


1990 ◽  
Vol 23 (4) ◽  
pp. 571-575
Author(s):  
Charles F. Koopmann, ◽  
Willard B. Moran

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