- Neutrophilic Granulocytes in the Treatment of Atherosclerosis

2012 ◽  
pp. 381-408
Keyword(s):  
Neutrophilic Granulocytes

The interaction of carbon nanoparticles with neutrophilic granulocytes: a target for therapeutic approaches

Pneumologie ◽  
2013 ◽  
Vol 67 (12) ◽  
Author(s):  
U Sydlik ◽  
U Krämer ◽  
M Kroker ◽  
A Paunel ◽  
S Keymel ◽  
...  
Keyword(s):  
Carbon Nanoparticles ◽  
Neutrophilic Granulocytes ◽  
Therapeutic Approaches

scholarly journals Synthetic Hexanucleotides as a Tool to Overcome Excessive Neutrophil Activation Caused by CpG-Containing Oligonucleotides

Pathogens ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 530
Author(s):  
Ekaterina A. Golenkina ◽  
Svetlana I. Galkina ◽  
Nina G. Dolinnaya ◽  
Evgenii A. Arifulin ◽  
Yulia M. Romanova ◽  
...  
Keyword(s):  
Neutrophil Activation ◽  
Immunomodulatory Activity ◽  
Neutrophilic Granulocytes ◽  
Negative Consequences ◽  
Prooxidant Effect ◽  
Bacterial Dna ◽  
Cpg Odns ◽  
Tissue Damages ◽  
The One ◽  
Tissue Origin

Mimicking bacterial DNA, synthetic CpG-containing oligodeoxyribonucleotides (CpG-ODNs) have a powerful immunomodulatory potential. Their practical application is mainly associated with the production of vaccines, where they are used as adjuvants, as well as in local antimicrobial therapy. CpG-ODNs act on a wide variety of immune cells, including neutrophilic granulocytes. On the one hand, the stimulatory effect provides both the direct implementation of their antimicrobial and fungicidal mechanisms, and an avalanche-like strengthening of the immune signal due to interaction with other participants in the immune process. On the other hand, hyperactivation of neutrophilic granulocytes can have negative consequences. In particular, the formation of unreasonably high amounts of reactive oxygen species leads to tissue damages and, as a consequence, a spontaneous aggravation and prolongation of the inflammatory process. Under physiological conditions, a large number of DNA fragments are present in inflammation foci: both of microbial and self-tissue origin. We investigated effects of several short modified hexanucleotides on the main indicators of neutrophil activation, as well as their influence on the immunomodulatory activity of known synthetic CpG-ODNs. The results obtained show that short oligonucleotides partially inhibit the prooxidant effect of synthetic CpG-ODNs without significantly affecting the ability of the latter to overcome bacteria-induced pro-survival effects on neutrophilic granulocytes.

Resonance Raman Imaging of the NADPH Oxidase Subunit Cytochromeb558in Single Neutrophilic Granulocytes

2003 ◽  
Vol 125 (40) ◽  
pp. 12112-12113 ◽  
Author(s):  
Henk-Jan van Manen ◽  
Natallia Uzunbajakava ◽  
Robin van Bruggen ◽  
Dirk Roos ◽  
Cees Otto
Keyword(s):  
Nadph Oxidase ◽  
Resonance Raman ◽  
Raman Imaging ◽  
Neutrophilic Granulocytes ◽  
Oxidase Subunit
Sign in / Sign up

Export Citation Format

Share Document