Case Studies Of Parallel Synthesis In Hit Identification, Hit Exploration, Hitto- Lead, And Lead Optimization Programs

2008 ◽  
pp. 99-115 ◽  
Author(s):  
Alexander Ernst ◽  
Daniel Obrecht
Keyword(s):  
Case Studies ◽  
Parallel Synthesis ◽  
Lead Optimization ◽  
Hit Identification

Applications of Parallel Synthesis to Lead Optimization

ChemInform ◽  
2004 ◽  
Vol 35 (4) ◽  
Author(s):  
Michael Altorfer ◽  
Philipp Ermert ◽  
Juerg Faessler ◽  
Saleem Farooq ◽  
Elke Hillesheim ◽  
...  
Keyword(s):  
Parallel Synthesis ◽  
Lead Optimization

Pyrazolo[1,5-a]pyrimidin-7-yl Phenyl Amides as Novel Antiproliferative Agents: Parallel Synthesis for Lead Optimization of Amide Region.

ChemInform ◽  
2005 ◽  
Vol 36 (29) ◽  
Author(s):  
Ariamala Gopalsamy ◽  
Hui Yang ◽  
John W. Ellingboe ◽  
Hwei-Ru Tsou ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Parallel Synthesis ◽  
Lead Optimization ◽  
Antiproliferative Agents

Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis

2004 ◽  
Vol 14 (7) ◽  
pp. 1717-1720 ◽  
Author(s):  
Tao Guo ◽  
Anton E.P. Adang ◽  
Guizhen Dong ◽  
Dan Fitzpatrick ◽  
Peng Geng ◽  
...  
Keyword(s):  
Small Molecule ◽  
Parallel Synthesis ◽  
Lead Optimization ◽  
Fsh Receptor ◽  
Receptor Agonists

Discovery and Lead Optimization of a Novel Series of CC Chemokine Receptor 1 (CCR1)-Selective Piperidine Antagonists via Parallel Synthesis

2012 ◽  
Vol 55 (22) ◽  
pp. 9643-9653 ◽  
Author(s):  
Cullen L. Cavallaro ◽  
Stephanie Briceno ◽  
Jing Chen ◽  
Mary Ellen Cvijic ◽  
Paul Davies ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Parallel Synthesis ◽  
Lead Optimization ◽  
Cc Chemokine ◽  
Chemokine Receptor 1

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region

2005 ◽  
Vol 15 (6) ◽  
pp. 1591-1594 ◽  
Author(s):  
Ariamala Gopalsamy ◽  
Hui Yang ◽  
John W. Ellingboe ◽  
Hwei-Ru Tsou ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Parallel Synthesis ◽  
Lead Optimization
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