Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery
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Published By Springer New York

9780387340562, 9780387449616

Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords

Optimizing Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_17 ◽

2007 ◽

pp. 411-421

Author(s):

Geoffrey S Ginsburg ◽

Julie Lekstrom-Himes ◽

William Trepicchio

Keyword(s):

Drug Development ◽

Clinical Studies ◽

Lead Optimization ◽

Optimization Stage

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Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_16 ◽

2007 ◽

pp. 355-410 ◽

Cited By ~ 17

Author(s):

Thomas J. Raub ◽

Barry S. Lutzke ◽

Paula K. Andrus ◽

Geri A. Sawada ◽

Brian A. Staton

Keyword(s):

Lead Optimization ◽

Preclinical Evaluation ◽

Brain Exposure ◽

Hit Identification

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Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_1 ◽

2007 ◽

pp. 1-23 ◽

Cited By ~ 1

Author(s):

Dhiren R. Thakker

Keyword(s):

In Vitro Models ◽

Pharmacokinetic Studies ◽

Lead Compounds ◽

Adme Properties

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The Relevance of Transporters in Determining Drug Disposition

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_18 ◽

2007 ◽

pp. 423-459

Author(s):

Hartmut Glaeser ◽

Richard B. Kim

Keyword(s):

Drug Disposition

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Case History: Toxicology Biomarker Development Using Toxicogenomics

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_12 ◽

2007 ◽

pp. 255-270 ◽

Cited By ~ 1

Author(s):

David E. Watson ◽

Timothy P. Ryan ◽

James L. Stevens

Keyword(s):

Case History

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The Application of PK/PD Modeling and Simulations During Lead Optimization

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_15 ◽

2007 ◽

pp. 323-353

Author(s):

Stuart Friedrich ◽

Evelyn Lobo ◽

Karen Zimmerman ◽

Anthony Borel ◽

Carlos O. Garner

Keyword(s):

Lead Optimization ◽

Modeling And Simulations

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Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_7 ◽

2007 ◽

pp. 151-166 ◽

Cited By ~ 6

Author(s):

Brian R. Rohrs

Keyword(s):

Oral Exposure

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Elementary Predictive Toxicology for Advanced Applications

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_14 ◽

2007 ◽

pp. 301-322

Author(s):

Constantine Kreatsoulas ◽

Stephen K. Durham ◽

Laura L. Custer ◽

Greg M. Pearl

Keyword(s):

Predictive Toxicology ◽

Advanced Applications

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Predicting Idiosyncratic Drug Reactions

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_13 ◽

2007 ◽

pp. 271-299

Author(s):

Alastair Cribb

Keyword(s):

Idiosyncratic Drug Reactions ◽

Drug Reactions

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Application of Physicochemical Data to Support Lead Optimization by Discovery Teams

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery ◽

10.1007/978-0-387-44961-6_8 ◽

2007 ◽

pp. 167-193 ◽

Cited By ~ 1

Author(s):

Li Di ◽

Edward H. Kerns

Keyword(s):

Lead Optimization ◽

Physicochemical Data

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Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug DiscoveryLatest Publications

TOTAL DOCUMENTS

H-INDEX

Published By Springer New York

Optimizing Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development

Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization

Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds

The Relevance of Transporters in Determining Drug Disposition

Case History: Toxicology Biomarker Development Using Toxicogenomics

The Application of PK/PD Modeling and Simulations During Lead Optimization

Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure

Elementary Predictive Toxicology for Advanced Applications

Predicting Idiosyncratic Drug Reactions

Application of Physicochemical Data to Support Lead Optimization by Discovery Teams

Biotechnology: Pharmaceutical Aspects - Optimizing the “Drug-Like” Properties of Leads in Drug Discovery
Latest Publications