Impaired Recognition Memory and Decreased Prefrontal Cortex Spine Density in Aged Female Rats

2007 ◽  
Vol 1097 (1) ◽  
pp. 54-57 ◽  
Author(s):  
M. WALLACE ◽  
M. FRANKFURT ◽  
A. ARELLANOS ◽  
T. INAGAKI ◽  
V. LUINE
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Female Rats ◽  
Spine Density

scholarly journals Estrogen-Induced Memory Enhancements Are Blocked by Acute Bisphenol A in Adult Female Rats: Role of Dendritic Spines

Endocrinology ◽  
2012 ◽  
Vol 153 (7) ◽  
pp. 3357-3367 ◽  
Author(s):  
T. Inagaki ◽  
M. Frankfurt ◽  
V. Luine
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Adult Female ◽  
Dendritic Spines ◽  
Environmental Protection Agency ◽  
Visual Memory ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Place Memory ◽  
Sample Trial

Acute effects of bisphenol (BPA), an environmental chemical, on estradiol (17α or β-E2)-dependent recognition memory and dendritic spines in the medial prefrontal cortex and hippocampus were investigated in adult female rats. Ovariectomized rats received BPA 30 min before or immediately after a sample trial (viewing objects), and retention trials were performed 4 h later. Retention trials tested discrimination between old and new objects (visual memory) or locations (place memory). When given immediately after the sample trial, BPA, 1–400 μg/kg, did not alter recognition memory, but 1 and 40 μg/kg BPA, respectively, blocked 17β-E2-dependent increases in place and visual memory. When ovariectomized rats were tested with 17α-E2, 1 μg/kg BPA blocked place memory, but up to 40 μg did not block visual memory. BPA, given to cycling rats at 40 μg/kg, blocked visual, but not place, memory during proestrus when 2 h intertrial delays were given. Spine density was assessed at times of memory consolidation (30 min) and retention (4 h) after 17β-E2 or BPA + 17β-E2. In prefrontal cortex, BPA did not alter E2-dependent increases. In the hippocampus, BPA blocked E2 increases in basal spines at 4 h and was additive with E2 at 30 min. Thus, these novel data show that doses of BPA, below the current Environmental Protection Agency safe limit of 50 μg/kg, rapidly alter neural functions dependent on E2 in adult female rats.

Neonatal Stress Has a Long-Lasting Sex-Dependent Effect on Anxiety-Like Behavior and Neuronal Morphology in the Prefrontal Cortex and Hippocampus

2018 ◽  
Vol 40 (2) ◽  
pp. 93-103 ◽  
Author(s):  
Silvana Regina de Melo ◽  
Caren Tatiane de David Antoniazzi ◽  
Shakhawat Hossain ◽  
Bryan Kolb
Keyword(s):  
Prefrontal Cortex ◽  
Locomotor Activity ◽  
Maternal Separation ◽  
Early Adulthood ◽  
Insular Cortex ◽  
Neuronal Morphology ◽  
Female Rats ◽  
Spine Density ◽  
Male And Female ◽  
Male And Female Rats

The long-lasting effects of early stress on brain development have been well studied. Recent evidence indicates that males and females respond differently to the same stressor. We examined the chronic effects of daily maternal separation (MS) on behavior and cerebral morphology in both male and female rats. Cognitive and anxiety-like behaviors were evaluated, and neuroplastic changes in 2 subregions of the prefrontal cortex (dorsal agranular insular cortex [AID] and cingulate cortex [Cg3]) and hippocampus (CA1 and dentate gyrus) were measured in adult male and female rats. The animals were subjected to MS on postnatal day (P) 3–14 for 3 h per day. Cognitive and emotional behaviors were assessed in the object/context mismatch task, elevated plus maze, and locomotor activity test in early adulthood (P87–P95). Anatomical assessments were performed in the prefrontal cortex (i.e., cortical thickness and spine density) and hippocampus (i.e., spine density). Sex-dependent effects were observed. MS increased anxiety-related behavior only in males, whereas locomotor activity was higher in females, with no effects on cognition. MS decreased spine density in the AID and increased spine density in the CA1 area in males. Females exhibited an increase in spine density in the Cg3. Our findings confirm previous work that found that MS causes long-term behavioral and anatomical effects, and these effects were dependent on sex and the duration of MS stress.

scholarly journals Medial prefrontal cortex role in recognition memory in rodents

2015 ◽  
Vol 292 ◽  
pp. 241-251 ◽  
Author(s):  
Juan Facundo Morici ◽  
Pedro Bekinschtein ◽  
Noelia V. Weisstaub
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Medial Prefrontal Cortex

scholarly journals Direct brain recordings reveal prefrontal cortex dynamics of memory development

2018 ◽  
Vol 4 (12) ◽  
pp. eaat3702 ◽  
Author(s):  
E. L. Johnson ◽  
L. Tang ◽  
Q. Yin ◽  
E. Asano ◽  
N. Ofen
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Scene Perception ◽  
Declarative Memory ◽  
Memory Formation ◽  
Developing Brain ◽  
Memory Development ◽  
Temporal Precision ◽  
Frontal Activity

Prevailing theories link prefrontal cortex (PFC) maturation to the development of declarative memory. However, the precise spatiotemporal correlates of memory formation in the developing brain are not known. We provide rare intracranial evidence that the spatiotemporal propagation of frontal activity supports memory formation in children. Seventeen subjects (6.2 to 19.4 years) studied visual scenes in preparation for a recognition memory test while undergoing direct cortical monitoring. Earlier PFC activity predicted greater accuracy, and subsecond deviations in activity flow between subregions predicted memory formation. Activity flow between inferior and precentral sites was refined during adolescence, partially explaining gains in memory. In contrast, middle frontal activity predicted memory independent of age. These findings show with subsecond temporal precision that the developing PFC links scene perception and memory formation and underscore the role of the PFC in supporting memory development.

Sign in / Sign up

Export Citation Format

Share Document