Ovariectomized rats show decreased recognition memory and spine density in the hippocampus and prefrontal cortex

2006 ◽  
Vol 1126 (1) ◽  
pp. 176-182 ◽  
Author(s):  
M. Wallace ◽  
V. Luine ◽  
A. Arellanos ◽  
M. Frankfurt
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Ovariectomized Rats ◽  
Spine Density

Dietary phytoestrogens enhance spatial memory and spine density in the hippocampus and prefrontal cortex of ovariectomized rats

2006 ◽  
Vol 1126 (1) ◽  
pp. 183-187 ◽  
Author(s):  
V. Luine ◽  
S. Attalla ◽  
G. Mohan ◽  
A. Costa ◽  
M. Frankfurt
Keyword(s):  
Prefrontal Cortex ◽  
Spatial Memory ◽  
Ovariectomized Rats ◽  
Spine Density

scholarly journals Estrogen-Induced Memory Enhancements Are Blocked by Acute Bisphenol A in Adult Female Rats: Role of Dendritic Spines

Endocrinology ◽  
2012 ◽  
Vol 153 (7) ◽  
pp. 3357-3367 ◽  
Author(s):  
T. Inagaki ◽  
M. Frankfurt ◽  
V. Luine
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Adult Female ◽  
Dendritic Spines ◽  
Environmental Protection Agency ◽  
Visual Memory ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Place Memory ◽  
Sample Trial

Acute effects of bisphenol (BPA), an environmental chemical, on estradiol (17α or β-E2)-dependent recognition memory and dendritic spines in the medial prefrontal cortex and hippocampus were investigated in adult female rats. Ovariectomized rats received BPA 30 min before or immediately after a sample trial (viewing objects), and retention trials were performed 4 h later. Retention trials tested discrimination between old and new objects (visual memory) or locations (place memory). When given immediately after the sample trial, BPA, 1–400 μg/kg, did not alter recognition memory, but 1 and 40 μg/kg BPA, respectively, blocked 17β-E2-dependent increases in place and visual memory. When ovariectomized rats were tested with 17α-E2, 1 μg/kg BPA blocked place memory, but up to 40 μg did not block visual memory. BPA, given to cycling rats at 40 μg/kg, blocked visual, but not place, memory during proestrus when 2 h intertrial delays were given. Spine density was assessed at times of memory consolidation (30 min) and retention (4 h) after 17β-E2 or BPA + 17β-E2. In prefrontal cortex, BPA did not alter E2-dependent increases. In the hippocampus, BPA blocked E2 increases in basal spines at 4 h and was additive with E2 at 30 min. Thus, these novel data show that doses of BPA, below the current Environmental Protection Agency safe limit of 50 μg/kg, rapidly alter neural functions dependent on E2 in adult female rats.

Impaired Recognition Memory and Decreased Prefrontal Cortex Spine Density in Aged Female Rats

2007 ◽  
Vol 1097 (1) ◽  
pp. 54-57 ◽  
Author(s):  
M. WALLACE ◽  
M. FRANKFURT ◽  
A. ARELLANOS ◽  
T. INAGAKI ◽  
V. LUINE
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Female Rats ◽  
Spine Density

scholarly journals Medial prefrontal cortex role in recognition memory in rodents

2015 ◽  
Vol 292 ◽  
pp. 241-251 ◽  
Author(s):  
Juan Facundo Morici ◽  
Pedro Bekinschtein ◽  
Noelia V. Weisstaub
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Medial Prefrontal Cortex

scholarly journals Direct brain recordings reveal prefrontal cortex dynamics of memory development

2018 ◽  
Vol 4 (12) ◽  
pp. eaat3702 ◽  
Author(s):  
E. L. Johnson ◽  
L. Tang ◽  
Q. Yin ◽  
E. Asano ◽  
N. Ofen
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Scene Perception ◽  
Declarative Memory ◽  
Memory Formation ◽  
Developing Brain ◽  
Memory Development ◽  
Temporal Precision ◽  
Frontal Activity

Prevailing theories link prefrontal cortex (PFC) maturation to the development of declarative memory. However, the precise spatiotemporal correlates of memory formation in the developing brain are not known. We provide rare intracranial evidence that the spatiotemporal propagation of frontal activity supports memory formation in children. Seventeen subjects (6.2 to 19.4 years) studied visual scenes in preparation for a recognition memory test while undergoing direct cortical monitoring. Earlier PFC activity predicted greater accuracy, and subsecond deviations in activity flow between subregions predicted memory formation. Activity flow between inferior and precentral sites was refined during adolescence, partially explaining gains in memory. In contrast, middle frontal activity predicted memory independent of age. These findings show with subsecond temporal precision that the developing PFC links scene perception and memory formation and underscore the role of the PFC in supporting memory development.

Recognition Memory for Emotional and Neutral Faces: An Event-Related Potential Study

2004 ◽  
Vol 16 (10) ◽  
pp. 1840-1853 ◽  
Author(s):  
Mikael Johansson ◽  
Axel Mecklinger ◽  
Anne-Cécile Treese
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Recognition Performance ◽  
Facial Affect ◽  
Test Phase ◽  
Event Related Potential ◽  
Affect Recognition ◽  
Negative Events ◽  
Familiarity And Recollection ◽  
Criterion Setting

This study examined emotional influences on the hypothesized event-related potential (ERP) correlates of familiarity and recollection (Experiment 1) and the states of awareness (Experiment 2) accompanying recognition memory for faces differing in facial affect. Participants made gender judgments to positive, negative, and neutral faces at study and were in the test phase instructed to discriminate between studied and nonstudied faces. Whereas old–new discrimination was unaffected by facial expression, negative faces were recollected to a greater extent than both positive and neutral faces as reflected in the parietal ERP old–new effect and in the proportion of remember judgments. Moreover, emotion-specific modulations were observed in frontally recorded ERPs elicited by correctly rejected new faces that concurred with a more liberal response criterion for emotional as compared to neutral faces. Taken together, the results are consistent with the view that processes promoting recollection are facilitated for negative events and that emotion may affect recognition performance by influencing criterion setting mediated by the prefrontal cortex.

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