Feasibility Analysis of Contents of Module Impulse and Momentum to Improve Student Math Skills Verbal Representation of Figures (R-VMGG)

This article reports on the results of the development of impulse and momentum modules to improve the Verbal, Mathematical, Image and Graphic Representation (R-VMGG) abilities of high school students in Besuki Raya. The research objective was to describe the feasibility level of the content, the impulse module and momentum of the development results. The trials were carried out on small samples and large samples, after validation by experts. The large sample trial is carried out after completing the small sample trial which is carried out in stages from all learning activities with the impulse and momentum module. Trials with small samples and large samples were carried out to investigate the impulse and momentum module drafts of the development results in improving the R-VMGG abilities of SMAN students in Besuki Raya. Respondents in the small sample trial were 30 high school students, while the respondents in the large sample trial were 150 high school students. The results showed that the feasibility level of the contents of the developed modules reached a high category

Pengembangan Media Pembelajaran Berbasis Virtual Reality Pada Mata Kuliah Anatomi Dan fisiologi Manusia Pada Mahasiswa Semester VI Pendidikan Biologi

The development of learning media based on virtual reality aims to determine the feasibility of this media in learning. This media is validated by two experts, namely material experts and media experts. During the validation of the media material expert, he received an assessment percentage of 79.8% and in his testing the media expert validation received a percentage of 96.8%, which means that the test is very valid. The sample trial was 9 people, got a percentage score of 74.6% (very feasible), while during the implementation trial there were about 19 people who got a percentage score of 79.2 (very feasible). From these trials it can be concluded that virtual reality learning media is very feasible and can be implemented into the real learning process.Keywords: Human Anatomy and Physiology, learning media, VR

Reasonable Care with Sample Data

This chapter considers reasonable decision making with sample data from randomized trials. It continues discussion of reasonable patient care under uncertainty. Because of its centrality to evidence-based medicine, the chapter focuses on the use of sample trial data in treatment choice. Moreover, having already addressed identification, the chapter considers only statistical imprecision, as has been the case in the statistical literature on trials. The Wald (1950) development of statistical decision theory provides a coherent framework for use of sample data to make decisions. A body of recent research applies statistical decision theory to determine treatment choices that achieve adequate performance in all states of nature, in the sense of maximum regret. This chapter describes the basic ideas and findings, which provide an appealing practical alternative to use of hypothesis tests.

PENGEMBANGAN MODUL ELEKTRONIK MATA KULIAH DESAIN GRAFIS PADA PROGRAM STUDI PENDIDIKAN TIK

This study aims to: 1) Produce the Electrocnik Graphic Design module in the P.TIK Study Program, IKIP PGRI Pontianak. 2) Knowing the student's feasibility and response to the Graphic Design electronic module. The research method used in this study is research and development. The research design used the Borg and Gall model. This research variable uses a single variable, namely the development of an electronic module in the Graphic Design course. The object of this study was the second semester students of the ICT Study Program IKIP-PGRI Pontianak 2017/2018. The results of the evaluation of the electronic module by the expert lecturer of the material obtained a score of 102.5 with eligibility criteria and the results of the evaluation of the electronic module by the media expert lecturer obtained a score of 94.5 with eligibility criteria .. While the response of students to electronic modules in a sample trial of 53 students obtained an average score of questionnaire 4 with good criteria. Based on these data it can be concluded that the electronic module application of graphic design developed is feasible and is good to use in the learning process

Designing clinical trials in 3L+ pancreatic cancer.

226 Background: An increasing percentage of pancreatic cancer (PC) patients are looking for 3L+ options. As patient outcomes are improving with advances in treatment for PC, more patients need 3L+ treatments. Few trials focus on this patient segment as evaluation of drug effects can be complicated by comorbidity rates and disease-related SAEs. Having exhausted SOC chemotherapy backbones, patients increasingly search for novel therapies and clinical trial options. This assessment was to evaluate 3L+ PC trials for 1) sufficient patient interest, 2) a clinically evaluable patient population, and 3) guidelines/restrictions that could improve clinical assessment. Methods: Initiated as a retrospective evaluation of consenting patients screened for a prospective 2L+ pancreatic cancer Phase II trial with SM-88. A comparison of recurrent PC trials was performed by Novella to assess industry wide enrollment characteristics. Results: 32% of patients searching for clinical trials YTD 2018 in PanCAN’s database were looking for 3L+ treatments, up from 25% in 2016. In the sample trial, rate of consents (n=72) increased hyperbolically, reaching ~1/pt/day by end of analysis (24 sites). Inc/exc criteria were broadly standard for sponsor-initiated trials, however ECOG PS 2 were eligible. 38% screen failed, with hepatic labs (esp Alb & ALP) as most common reason. Industry analysis indicated expected 0.35 p/s/m for refractory PC trials and 20% screen fail. 93% (37/40) of SAEs were unrelated to study drug, including 11 G4 or G5 prior to receiving drug. Preliminary safety and efficacy results for the trial are reported elsewhere. Conclusions: Rapid enrollment from 3L+ patients demonstrated significant interest among this patient segment. The screen failure rate was within reasonable expectations, implying a majority of the patients were within standard inc/exc criteria. The high level of unrelated SAEs during the consent period and initial enrollment period indicate this may not be a suitable population to properly assess drug safety. Subgroup statistical analyses may be more relevant than ITT medians since several comorbidities, such as biliary obstruction, have elsewhere been demonstrated to have a dramatic impact on OS. Clinical trial information: NCT03512756.

The Object Space Task shows cumulative memory expression in both mice and rats

ABSTRACTDeclarative memory encompasses representations of specific events as well as knowledge extracted by accumulation over multiple episodes. To investigate how these different sorts of memories are created, we developed a new behavioral task in rodents. The task consists of three distinct conditions (stable, overlapping, random). Rodents are exposed to multiple sample trials, in which they explore objects in specific spatial arrangements. In the stable condition, the locations are constant during all sample trials; in the test trial, one object’s location is changed. In the random condition, object locations are presented in the sample phase without a specific spatial pattern. In the overlapping condition, one location is shared (overlapping) between all trials while the other location changes during sample trials. We show that in the overlapping condition, instead of only remembering the last sample trial, rodents form a cumulative memory of the sample trials.Here we could show that both mice and rats can accumulate information across multiple trials and express a long-term abstracted memory.

A 3-Arm, Randomized, Controlled Trial of Heat-Sensitive Moxibustion Therapy to Determine Superior Effect among Patients with Lumbar Disc Herniation

Systematic reviews of moxibustion for LDH have identified ponderable evidence, especially for heat-sensitive moxibustion (HSM). Therefore, we designed and carried out the large sample trial to evaluate it. 456 patients were recruited from 4 centers in China and were randomly divided into three groups by the ratio of 1 : 1 : 1 to HSM (152) group, conventional moxibustion (152) group, and conventional drug plus acupuncture (152) group. Compared with usual care, there was a statistically significant reduction in mean M-JOA score at 2 weeks and 6 months for HSM (3.8 ± 2.6 versus 8.5 ± 2.9; 3.7 ± 2.2 versus 10.1 ± 2.9) and conventional moxibustion (7.9 ± 3.0 versus 8.5 ± 2.9; 8.9 ± 3.1 versus 10.1 ± 2.9). Compared with conventional moxibustion group, HSM group showed greater improvement in all the outcomes. The mean dose of moxibustion was 41.13 ± 5.26 (range 21–60) minutes in the HSM group. We found that HSM was more effective in treating patients with LDH, compared with conventional moxibustion and conventional drug plus acupuncture. This finding indicated that the application of moxibustion on the heat-sensitive points is a good moxibustion technique in treating disease.

Estrogen-Induced Memory Enhancements Are Blocked by Acute Bisphenol A in Adult Female Rats: Role of Dendritic Spines

Acute effects of bisphenol (BPA), an environmental chemical, on estradiol (17α or β-E2)-dependent recognition memory and dendritic spines in the medial prefrontal cortex and hippocampus were investigated in adult female rats. Ovariectomized rats received BPA 30 min before or immediately after a sample trial (viewing objects), and retention trials were performed 4 h later. Retention trials tested discrimination between old and new objects (visual memory) or locations (place memory). When given immediately after the sample trial, BPA, 1–400 μg/kg, did not alter recognition memory, but 1 and 40 μg/kg BPA, respectively, blocked 17β-E2-dependent increases in place and visual memory. When ovariectomized rats were tested with 17α-E2, 1 μg/kg BPA blocked place memory, but up to 40 μg did not block visual memory. BPA, given to cycling rats at 40 μg/kg, blocked visual, but not place, memory during proestrus when 2 h intertrial delays were given. Spine density was assessed at times of memory consolidation (30 min) and retention (4 h) after 17β-E2 or BPA + 17β-E2. In prefrontal cortex, BPA did not alter E2-dependent increases. In the hippocampus, BPA blocked E2 increases in basal spines at 4 h and was additive with E2 at 30 min. Thus, these novel data show that doses of BPA, below the current Environmental Protection Agency safe limit of 50 μg/kg, rapidly alter neural functions dependent on E2 in adult female rats.

Compressive Strength Characterization of Polyester Based Fillers

This paper investigates the compressive properties of polyester based fillers with different proportions of resin, sand and fly ash. The research program aims at developing a polymer based filler for a glass fibre reinforced polymer (GFRP) tube to be used as a structural rehabilitation system. It has been initiated to improve fundamental understanding of this material and to provide the knowledge required for its broad utilization. In this development, sample trial mixes were considered based on several weight percentages of polyester resin, fly ash and sand. These weight percentages were selected after analyzing volumetric properties of sand. The effect of resin (binder), sand and fly ash contents on the compressive strength of polyester based fillers with respect to age is reported. It has been found that at the age of 7 days all the batches reached about 90% of the compressive modulus. The experimental compressive stress-strain curves reported here were compared with established analytical models for normal strength concrete.