scholarly journals Plasma triglyceride/HDL-cholesterol ratio, insulin resistance, and cardiometabolic risk in young adults

2013 ◽  
Vol 54 (10) ◽  
pp. 2795-2799 ◽  
Author(s):  
Miguel Murguía-Romero ◽  
J. Rafael Jiménez-Flores ◽  
Santiago C. Sigrist-Flores ◽  
Miguel A. Espinoza-Camacho ◽  
Mayra Jiménez-Morales ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Young Adults ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Plasma Triglyceride ◽  
Cholesterol Ratio

scholarly journals Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

2016 ◽  
Vol 115 (11) ◽  
pp. 1994-2002 ◽  
Author(s):  
Lucinda J. Black ◽  
Sally Burrows ◽  
Robyn M. Lucas ◽  
Carina E. Marshall ◽  
Rae-Chi Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
Inverse Association ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Over Time

AbstractEvidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient −0·01; 95 % CI −0·03, −0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient −0·002; 95 % CI −0·003, −0·001; P<0·001) and positively associated with log-TAG in females (coefficient 0·002; 95 % CI 0·0008, 0·004; P=0·003). These associations did not vary over time. There were no significant associations between serum 25(OH)D concentrations and HDL-cholesterol or SBP. Clinical trials in those with insufficient vitamin D status may be warranted to determine any beneficial effect of vitamin D supplementation on insulin resistance, while monitoring for any deleterious effect on TAG.

The Triglyceride/HDL-Cholesterol Ratio as a Tool to Predict Insulin Resistance in Obese Pediatric Patients∗

2012 ◽  
Vol 6 (3) ◽  
pp. 267
Author(s):  
Jerry Walkup ◽  
Michael B. Johnson ◽  
Kendra Simpson ◽  
Marielisa Rincon ◽  
Delisa Allen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Pediatric Patients ◽  
Hdl Cholesterol ◽  
Cholesterol Ratio

Identification of Cardiometabolic Risk: Visceral Adiposity Index Versus Triglyceride/HDL Cholesterol Ratio

2014 ◽  
Vol 127 (2) ◽  
pp. 152-157 ◽  
Author(s):  
Martin R. Salazar ◽  
Horacio A. Carbajal ◽  
Walter G. Espeche ◽  
Marcelo Aizpurúa ◽  
Pablo M. Maciel ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Cholesterol Ratio ◽  
Adiposity Index

scholarly journals Insulin Resistance Indexes as Biomarkers of Lifetime Cardiovascular Risk among Adults from Peru

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Ricardo Rojas-Humpire ◽  
Mely Olarte-Durand ◽  
Sebastian Medina-Ramirez ◽  
Rosmery Gutierrez-Ajalcriña ◽  
Josue F. Canaza ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Hdl Cholesterol ◽  
Roc Curves ◽  
Youden Index ◽  
Optimal Cutoff ◽  
Cross Sectional ◽  
Men And Women ◽  
Cholesterol Ratio ◽  
Cutoff Values

Background. Cardiovascular disease (CVD) is the most prevalent cause of death from disease and disability in the world. Reliable markers are needed to assess and reduce cardiovascular risk. This study aimed to determine if insulin resistance indexes, triglycerides to HDL-cholesterol ratio (TG/HDL-C), and triglyceride glucose index (TyG) are biomarkers for lifetime cardiovascular risk (CVR). Methods. This analytical cross-sectional study was performed on health personnel from Huaycan Hospital in Peru. The QRISK model was used to measure lifetime CVR. The association and diagnostic accuracy for TyG calculated as Ln (TG (mg/dL) × glucose (mg/dL)/2) and TG/HDL-C ratio were determined using Poisson regression models and ROC curves with Youden index. Results. In total, 291 adults (207 women and 84 men) were analyzed. In the adjusted Poisson models, each unit of TG/HDL-C increased 1.22-fold and 1.16-fold the probability of high lifetime CVR in men and women, respectively. However, each unit of TyG increased 1.98-fold in men and 3.25-fold in women the probability of high lifetime CVR. The optimal cutoff values of TG/HDL-C were 2.64 (AUC: 0.77), 3.90 (AUC: 0.80), and 2.64 (AUC: 0.74) for the overall population, men, and women, respectively. Likewise, the optimal cutoff values of TyG were 9.04 (AUC: 0.80), 8.95 (AUC: 0.79), and 9.04 (AUC: 0.80) for the overall population, men, and women, respectively. Conclusion. TG/HDL-C and TyG presented a significant association with lifetime CVR. However, TyG presented a stronger association than TG/HDL-C. Both TG/HDL-C and TyG are shown to be reliable markers for CVR in adults.

scholarly journals Prospective association between a Mediterranean-style dietary score in childhood and cardiometabolic risk in young adults from the ALSPAC birth cohort

2021 ◽  
Author(s):  
Genevieve Buckland ◽  
Caroline M. Taylor ◽  
Pauline M. Emmett ◽  
Laura Johnson ◽  
Kate Northstone
Keyword(s):  
Young Adults ◽  
Cardiometabolic Risk ◽  
Eating Habits ◽  
Hdl Cholesterol ◽  
Cardiometabolic Health ◽  
Model Assessment ◽  
Logistic Regression Models ◽  
Arterial Blood ◽  
Parents And Children ◽  
Prospective Association

Abstract Purpose To investigate the prospective association between a children’s relative Mediterranean-style diet score (C-rMED) in childhood and a Cardiometabolic Risk (CMR) score in adolescence/young adulthood in the Avon Longitudinal Study of Parents and Children (ALSPAC). Methods A C-rMED was calculated at 7, 10 and 13 years from diet diary data. Anthropometric and biochemical data at 17 (N = 1940) and 24 years (N = 1961) were used to calculate CMR scores (sum of sex-specific log-transformed z-scores from triacylglycerol, HDL cholesterol, LDL cholesterol, mean arterial blood pressure, homeostatic model assessment of insulin resistance (HOMA-IR) and fat mass index (FMI)). Adjusted logistic regression models examined associations between C-rMED (categorical and 2-unit increments) and a high CMR score (≥ 80th percentile) and individual CMR components (≥ 80th percentile). Results A high C-rMED at 13 was associated with a 32% (OR 0.68 (95% CI: 0.49, 0.94)) decreased adjusted odds of having a high CMR score at 24 years, compared to participants with a low C-rMED. No associations were evident at other ages. Tracking of the C-rMED across the three ages showed a stronger negative association between C-rMED and CMR at 24 years when children had at least two high C-rMED scores from 7 to 13 years (adjusted OR: 0.49, 95% CI: 0.29, 0.85), compared to all low scores. FMI and HOMA-IR were the main CMR components contributing to this association. Conclusion Higher Mediterranean-style diet scores in early adolescence were associated with a better CMR profile in young adults (24 year olds). This underscores the importance of establishing healthy eating habits early in life for future cardiometabolic health.

scholarly journals Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults

2015 ◽  
Vol 172 (3) ◽  
pp. 291-300 ◽  
Author(s):  
Rui Wang ◽  
Jie Hong ◽  
Yanan Cao ◽  
Juan Shi ◽  
Weiqiong Gu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Young Adults ◽  
Insulin Sensitivity ◽  
Hdl Cholesterol ◽  
Circulating Microrna ◽  
Model Assessment ◽  
Obese Patients ◽  
Serum Samples ◽  
Functional Studies ◽  
Control Subjects

ObjectiveMicroRNAs (miRNAs) are involved in the regulation of adiposity, but functional studies have yielded inconclusive results. Examining the associations of circulating miRNAs levels with obesity and insulin sensitivity in humans may lead to improved insights.Design and methodsSerum samples collected from 112 obese and control subjects (50.0% men) were randomly divided and combined into four pools (28 samples in each obese or control pool). The genome-wide circulating miRNA profiles were detected via microarray. Elevated miR-122 was selected and validated in individual serum samples from 123 obese (46.7% men) and 107 control (50.0% men) young adults. Associations between circulating miR-122 levels and parameters related to adiposity, insulin resistance, lipid profiles and hepatic enzymes were further assessed.ResultsThirty-four miRNAs were found to be expressed differently in the sera of obese patients compared with control subjects (P<0.001). Further analyses confirmed that obese patients had 3.07-fold higher circulating miR-122 levels than controls (P<0.001). Serum miR-122 levels were correlated with BMI (r=0.469), alanine aminotransferase (r=0.634), triglycerides (r=0.448), HDL-cholesterol (r=−0.351) and homeostasis model assessment of insulin resistance (r=0.401, allP<0.01). After controlling for confounding factors, miR-122 remained as an independent risk factor for insulin resistance (OR=3.379, 95% CI=1.141–10.007,P=0.028).ConclusionsElevated circulating miR-122 is positively associated with obesity and insulin resistance in young adults. These findings provide a better understanding regarding the role of miRNAs in adiposity and insulin sensitivity.

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