Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents

2014 ◽  
Vol 24 (7) ◽  
pp. 737-743 ◽  
Author(s):  
L. Pacifico ◽  
E. Bonci ◽  
G. Andreoli ◽  
S. Romaggioli ◽  
R. Di Miscio ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Carotid Artery ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Intima Media Thickness ◽  
Nonalcoholic Fatty Liver ◽  
Cholesterol Ratio

scholarly journals Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Ya-Nan Zhang ◽  
Qin-Qiu Wang ◽  
Yi-Shu Chen ◽  
Chao Shen ◽  
Cheng-Fu Xu
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver ◽  
Cholesterol Ratio

Background/Aim. The risk factors for nonalcoholic fatty liver disease (NAFLD) in lean population have not been fully clarified. This study aimed to explore the association between uric acid to HDL-cholesterol ratio (UHR) and NAFLD in lean Chinese adults. Methods. A cross-sectional study was performed among 6285 lean Chinese adults (body mass index < 24 kg/m2) who took their annual health checkups. NAFLD was diagnosed based on hepatic ultrasound examination, with exclusion of other etiologies. Results. Of 6285 lean participants enrolled, 654 NAFLD cases were diagnosed. The overall NAFLD prevalence was 10.41%, and the prevalence was 15.45% and 7.16% in men and women, respectively. UHR was significantly higher in NAFLD patients than in controls (14.25 ± 5.33% versus 10.09 ± 4.23%, P<0.001). UHR quintiles were positively associated with NAFLD prevalence, which was 1.91% in the first UHR quintile and increased to 3.58%, 7.81%, 14.17%, and 24.54% in the second, third, fourth, and fifth quintile groups, respectively (P<0.001 for trend). Multivariate logistic regression analysis showed that UHR was independently associated with an increased risk of NAFLD (odds ratio: 1.105; 95% CI: 1.076–1.134; P<0.001). Sensitivity analysis showed that UHR remained significantly associated with NAFLD in lean participants with normal range of serum uric acid and HDL-cholesterol levels. Conclusions. UHR was significantly associated with NAFLD and may serve as a novel and reliable marker for NAFLD in lean adults.

Carotid Artery Intima-media Thickness in Nonalcoholic Fatty Liver Disease

2008 ◽  
Vol 121 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Anna Ludovica Fracanzani ◽  
Larry Burdick ◽  
Sara Raselli ◽  
Paola Pedotti ◽  
Liliana Grigore ◽  
...  
Keyword(s):  
Liver Disease ◽  
Carotid Artery ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Intima Media Thickness ◽  
Nonalcoholic Fatty Liver ◽  
Media Thickness

scholarly journals Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model*

Hepatology ◽  
2013 ◽  
Vol 57 (2) ◽  
pp. 566-576 ◽  
Author(s):  
Marcela Aparicio-Vergara ◽  
Pascal P.H. Hommelberg ◽  
Marijke Schreurs ◽  
Nanda Gruben ◽  
Rinke Stienstra ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Tumor Necrosis Factor ◽  
Fatty Liver ◽  
Murine Model ◽  
Fatty Liver Disease ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Nonalcoholic Fatty Liver ◽  
Necrosis Factor
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