scholarly journals Obstetric complications and affective psychoses

2000 ◽  
Vol 176 (6) ◽  
pp. 523-526 ◽  
Author(s):  
M. Bain ◽  
E. Juszczak ◽  
K. McInneny ◽  
R. E. Kendell
Keyword(s):  
Birth Cohort ◽  
Early Onset ◽  
Obstetric Complications ◽  
Affective Psychosis ◽  
Affective Psychoses ◽  
Patient Diagnosis

BackgroundUnlike schizophrenia, little interest has been taken in the incidence of obstetric complications in affective psychoses.AimsTo find out whether obstetric complications are more common in affective psychoses than matched controls.MethodTwo hundred and seventeen probands with an in-patient diagnosis of affective psychosis who had been born in Scotland in 1971–74, and a further 84 born in 1975–78, were closely matched with controls and the incidence of obstetric complications in the two compared using obstetric data recorded in a set format shortly after birth.ResultsAbnormal presentation of the foetus was the only complication significantly more common in the affective probands in the 1971–74 birth cohort and artificial rupture of the membranes was the only event more common in the probands in the 1975–78 cohort. Both are probably chance findings.ConclusionIt is unlikely that the incidence of obstetric complications is raised in people with affective psychoses of early onset.

scholarly journals Obstetric complications and schizophrenia

2000 ◽  
Vol 176 (6) ◽  
pp. 516-522 ◽  
Author(s):  
R. E. Kendell ◽  
K. McInneny ◽  
E. Juszczak ◽  
M. Bain
Keyword(s):  
Caesarean Section ◽  
Birth Cohort ◽  
Case Control ◽  
Emergency Caesarean Section ◽  
Obstetric Complications ◽  
Small Scale ◽  
Case Control Studies ◽  
Emergency Caesarean ◽  
Patient Diagnosis

BackgroundMost previous case–control studies of obstetric complications in schizophrenia have been small scale and many have relied on retrospective information.AimsTo determine which obstetric complications are more common in probands with schizophrenia than matched controls.MethodTwo hundred and ninety-six probands with an in-patient diagnosis of schizophrenia who had been born in Scotland in 1971–74, and a further 156 born in 1975–78, were closely matched with controls and the incidence of obstetric complications in the two compared using obstetric data recorded in a set format shortly after birth.ResultsNot a single complication of pregnancy or delivery was significantly more common in the probands with schizophrenia than the controls in the 1971–74 birth cohort and only emergency Caesarean section and labour lasting over 12 hours were significantly more common in the schizophrenia probands in the 1975–78 cohort.ConclusionThe evidence that schizophrenia is associated with a raised incidence of obstetric complications is weaker than has recently been assumed.

Association between psychotic disorder and urban place of birth is not mediated by obstetric complications or childhood socio-economic position: a cohort study

2003 ◽  
Vol 33 (4) ◽  
pp. 723-731 ◽  
Author(s):  
G. HARRISON ◽  
D. FOUSKAKIS ◽  
F. RASMUSSEN ◽  
P. TYNELIUS ◽  
A. SIPOS ◽  
...  
Keyword(s):  
Maternal Education ◽  
Disease Risk ◽  
Hazard Ratio ◽  
Obstetric Complications ◽  
Place Of Birth ◽  
Urban Place ◽  
Affective Psychosis ◽  
Affective Psychoses ◽  
Increased Risk ◽  
Economic Position

Background. Although urban place of birth has been identified as a risk factor for schizophrenia, the extent to which this association is mediated by socially patterned risk factors such as obstetric complications and childhood socio-economic position is unclear. The diagnostic specificity of the association within the clinical psychotic syndromes is also unclear.Method. A population cohort of 696025 males and females, born in Sweden between 1973 and 1980 and with linked birth and socio-economic data was followed up from age 16 for up to 9·8 years. Hospitalized cases of schizophrenia and other non-affective psychosis were identified from the Swedish Inpatient Discharge Register. We examined associations of these disorders with a three-level measure of urbanicity of birthplace before and after controlling for measures of foetal nutrition, obstetric complications and level of maternal education.Results. Urban compared to rural birthplace was associated both with increased risk of adult onset schizophrenia (hazard ratio 1·34, CI 0·91–1·96) and other non-affective psychoses (hazard ratio 1·63, CI 1·18–2·26). None of these associations was greatly affected by adjustment for obstetric complications or maternal educational level. In the group of other non-affective psychoses urban–rural differences in disease risk were strongest among those born in the winter months.Conclusion. Urbanization of birthplace is associated with increased risk of non-affective psychosis but this is not confined to narrowly defined cases. The magnitude of the association in Sweden is lower than that reported in other studies. Causal factors underlying this association appear to operate independently of risks associated with obstetric complications and parental educational status.

Early-onset of symptoms predicts conversion to non-affective psychosis in ultra-high risk individuals

2006 ◽  
Vol 84 (1) ◽  
pp. 67-76 ◽  
Author(s):  
G.P. Amminger ◽  
S. Leicester ◽  
A.R. Yung ◽  
L.J. Phillips ◽  
G.E. Berger ◽  
...  
Keyword(s):  
High Risk ◽  
Early Onset ◽  
Affective Psychosis ◽  
Ultra High Risk

Obstetric complications, treatment response and brain morphology in adult-onset and early-onset males with schizophrenia

1998 ◽  
Vol 28 (3) ◽  
pp. 645-653 ◽  
Author(s):  
G. N. SMITH ◽  
L. C. KOPALA ◽  
J. S. LAPOINTE ◽  
G. W. MacEWAN ◽  
S. ALTMAN ◽  
...  
Keyword(s):  
Treatment Response ◽  
Early Onset ◽  
Age At Onset ◽  
Obstetric Complications ◽  
Brain Morphology ◽  
Brain Anatomy ◽  
Adult Onset ◽  
Course Of Illness ◽  
Illness Onset ◽  
Duration Of Illness

Background. Substantial variability in age at onset of illness and course of illness exists between patients with schizophrenia. Recent studies suggest that age at illness onset may be useful in defining biologically and clinically distinct subgroups of patients.Methods. Two hundred and ten males with schizophrenia were classified as early-onset or adult-onset according to their age at first hospitalization. Birth history, clinical functioning and treatment response was assessed in a subgroup of patients. Brain anatomy was assessed from CT scans in all patients and in 32 non-psychiatric control subjects.Results. Patients with an early-onset were likely to have a history of obstetric complications, a poor response to neuroleptic treatment, and showed no relationship between ventricle size and duration of illness. Adult-onset patients were less likely to have obstetric complications, more likely to respond to treatment in the first years of illness, and showed an association between brain structure and duration of illness.Conclusions. The distinction between early- and adult-onset patients may have important aetiological and treatment implications.

scholarly journals Perinatal risk factors for early onset of Type 1 diabetes in a 2000-2005 birth cohort

2009 ◽  
Vol 26 (12) ◽  
pp. 1193-1197 ◽  
Author(s):  
C. S. Algert ◽  
A. McElduff ◽  
J. M. Morris ◽  
C. L. Roberts
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Birth Cohort ◽  
Early Onset ◽  
Perinatal Risk Factors ◽  
Perinatal Risk

Familial Psychiatric Illness and Obstetric Complications in Early-Onset Affective Disorder

1993 ◽  
Vol 163 (4) ◽  
pp. 492-498 ◽  
Author(s):  
Christian Guth ◽  
Peter Jones ◽  
Robin Murray
Keyword(s):  
Affective Disorder ◽  
Early Onset ◽  
Psychiatric Illness ◽  
Familial Risk ◽  
Adult Life ◽  
Obstetric Complications ◽  
History Of ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Early-onset affective disorder is associated with obstetric complications and a high familial risk of psychiatric illness, in particular psychosis. In a matched case-control study, we investigated 47 adult in-patients with major depressive disorder or bipolar 1 disorder, who had earlier in life presented to a child psychiatry department. Cases were matched on sex, social class and ethnic group with 47 controls, who were admitted to hospital for affective disorders in adult life but had no psychiatric contact before the age of 21. We found that both psychiatric disorder in first-degree relatives and a history of obstetric complications were associated with early onset. Childhood symptoms did not predict the type of adult affective disorder.

Growth in Young Adults Who Screen Positive for Non-Affective Psychosis: Birth Cohort Study

2009 ◽  
Vol 43 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Joy Welham ◽  
James Scott ◽  
Gail Williams ◽  
Jake Najman ◽  
Michael O'Callaghan ◽  
...  
Keyword(s):  
Young Adults ◽  
Cohort Study ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Affective Psychosis

scholarly journals Associations between premorbid intellectual performance, early-life exposures and early-onset schizophrenia

2002 ◽  
Vol 181 (4) ◽  
pp. 298-305 ◽  
Author(s):  
David Gunnell ◽  
Glynn Harrison ◽  
Finn Rasmussen ◽  
Dimitris Fouskakis ◽  
Per Tynelius
Keyword(s):  
Early Onset ◽  
Intellectual Development ◽  
Parental Education ◽  
Complete Data ◽  
Intellectual Performance ◽  
Affective Psychoses ◽  
Admission Data ◽  
Increased Risk ◽  
Early Life Exposures

BackgroundImpaired intellectual performance is associated with an increased risk of schizophrenia.AimsTo investigate whether this association is due to the influence of prenatal and early childhood exposures on both intellectual development and the risk of schizophrenia.MethodCohort of 197 613 Swedish male conscripts with linked birth, census and hospital admission data together with five measures of verbal and non-verbal intellectual performance recorded at conscription. Results 109 643 subjects had complete data; over a mean 5-year follow-up, 60 developed schizophrenia and 92 developed other non-affective psychoses. Poor scores for each of the five tests were associated with 3-to 14-fold increased risk of psychosis, particularly schizophrenia. Controlling for birth-related exposures, including birth weight, and parental education did not attenuate these associations.Results109 643 subjects had complete data; over amean 5-year follow-up,60 developed schizophrenia and 92 developed other non-affective psychoses. Poor scores for each of the five testswere associatedwith 3-to 14-foldincreasedrisk of psychosis, particularly schizophrenia. Controlling for birth-related exposures, including birthweight, and parental education didnot attenuate these associations.ConclusionsPoor intellectual performance at 18 years of age is associated with early-onset psychotic disorder. Associations do not appear to be confounded by prenatal adversity or childhood circumstances, as indexed by parental education.

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