Early-onset of symptoms predicts conversion to non-affective psychosis in ultra-high risk individuals

2006 ◽  
Vol 84 (1) ◽  
pp. 67-76 ◽  
Author(s):  
G.P. Amminger ◽  
S. Leicester ◽  
A.R. Yung ◽  
L.J. Phillips ◽  
G.E. Berger ◽  
...  
Keyword(s):  
High Risk ◽  
Early Onset ◽  
Affective Psychosis ◽  
Ultra High Risk

Cannabis use and transition to psychosis in people at ultra-high risk

2014 ◽  
Vol 44 (12) ◽  
pp. 2503-2512 ◽  
Author(s):  
L. R. Valmaggia ◽  
F. L. Day ◽  
C. Jones ◽  
S. Bissoli ◽  
C. Pugh ◽  
...  
Keyword(s):  
High Risk ◽  
Early Onset ◽  
Temporal Relationship ◽  
Clinical Presentation ◽  
Late Onset ◽  
Cannabis Use ◽  
Frequent Use ◽  
Increased Risk ◽  
Ultra High Risk ◽  
Continued Use

BackgroundCannabis use is associated with an increased risk of developing a psychotic disorder but the temporal relationship between cannabis use and onset of illness is unclear. The objective of this study was to assess prospectively the influence of cannabis use on transition to psychosis in people at ultra-high risk (UHR) for the disorder.MethodLifetime and continued cannabis use was assessed in a consecutively ascertained sample of 182 people (104 male, 78 female) at UHR for psychosis. Individuals were then followed clinically for 2 years to determine their clinical outcomes.ResultsLifetime cannabis use was reported by 134 individuals (73.6%). However, most of these individuals had stopped using cannabis before clinical presentation (n = 98, 73.1%), usually because of adverse effects. Among lifetime users, frequent use, early-onset use and continued use after presentation were all associated with an increase in transition to psychosis. Transition to psychosis was highest among those who started using cannabis before the age of 15 years and went on to use frequently (frequent early-onset use: 25%; infrequent or late-onset use: 5%; χ21 = 10.971, p = 0.001). However, within the whole sample, cannabis users were no more likely to develop psychosis than those who had never used cannabis (cannabis use: 12.7%; no use: 18.8%; χ21 = 1.061, p = 0.303).ConclusionsIn people at UHR for psychosis, lifetime cannabis use was common but not related to outcome. Among cannabis users, frequent use, early-onset use and continued use after clinical presentation were associated with transition to psychosis.

P300 amplitude attenuation in high risk and early onset psychosis youth

2019 ◽  
Vol 210 ◽  
pp. 228-238 ◽  
Author(s):  
Kelsey Graber ◽  
Michelle Bosquet Enlow ◽  
Frank H. Duffy ◽  
Eugene D'Angelo ◽  
Georgios Sideridis ◽  
...  
Keyword(s):  
High Risk ◽  
Early Onset ◽  
P300 Amplitude ◽  
Amplitude Attenuation ◽  
Early Onset Psychosis

Global fractional anisotropy predicts transition to psychosis after 12 months in individuals at ultra‐high risk for psychosis

2021 ◽  
Author(s):  
Tina D. Kristensen ◽  
Louise B. Glenthøj ◽  
Karen Ambrosen ◽  
Warda Syeda ◽  
Jayachandra M. Ragahava ◽  
...  
Keyword(s):  
High Risk ◽  
Fractional Anisotropy ◽  
Ultra High Risk
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