A Critical Appraisal of X-Linked Bipolar Illness

1992 ◽  
Vol 160 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Johannes Hebebrand
Keyword(s):  
Critical Appraisal ◽  
Depressive Illness ◽  
Dominant Mode ◽  
Manic Depressive Illness ◽  
The Past ◽  
X Linkage ◽  
Manic Depressive ◽  
Segregation Ratios ◽  
Assumed Mode ◽  
Mode Of Inheritance

The major assumption underlying all X-linkage studies of bipolar disorder has been that a subgroup of manic–depressive illness follows an X-linked dominant mode of inheritance. An evaluation of the segregation patterns in the pedigrees that have been analysed for X-linkage over the past 20 years does not support this assumption, because the formal genetic criteria for an X-linked dominant mode of inheritance are virtually absent. Not a single pedigree has been ascertained in which the segregation pattern is suggestive of the assumed mode of inheritance. This is mainly because segregation ratios characteristic for X-linked dominant inheritance cannot be observed among the offspring of affected males.

scholarly journals X-linkage in manic-depressive illness.

BMJ ◽  
1973 ◽  
Vol 3 (5874) ◽  
pp. 290-290
Author(s):  
J Mendlewicz ◽  
J D Rainer
Keyword(s):  
Depressive Illness ◽  
Manic Depressive Illness ◽  
X Linkage ◽  
Manic Depressive

scholarly journals Revisiting Shimoda's “Shuuchaku-Kishitsu” (Statothymia): A Japanese View of Manic-Depressive Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-7
Author(s):  
Hitoshi Tsuda
Keyword(s):  
Clinical Significance ◽  
Outer Space ◽  
Academic Research ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
The Past ◽  
Manic Depressive ◽  
Continental Origin ◽  
Personality Features ◽  
Depressive Patients

Although the empiric paradigm is now dominant in academic research, in Japan quite a few psychiatric clinicians still take phenomenological-anthropological approaches into consideration, especially when they address manic-depressive illness with typical endogenous features. This is because Shimoda's concept of “shuuchaku-kishitsu” (statothymia) has been widely accepted, together with other phenomenological views of continental origin. In the present paper the author first delineates Shimoda's concept which is based on observations of patients' personality features and the characteristics of their emotionality. He then attempts to refine this concept in spatiotemporal terms, presenting the view that in patients the past self tends to adhere to the present self (the term “shuuchaku” means “adhering to” or “preoccupied with”). He also considers that patients tend to incorporate “soto” (outer space) into “uchi” (inner space), where they believe that symbiotic relations are preserved. Finally, he argues the clinical significance of the presented views in the cultural milieu in which Japanese psychiatric practices are situated.

X-Linkage and Manic-Depressive Illness

1975 ◽  
Vol 127 (5) ◽  
pp. 482-488 ◽  
Author(s):  
Armand W. Loranger
Keyword(s):  
Genetic Markers ◽  
Depressive Illness ◽  
Linkage Studies ◽  
Review Of The Literature ◽  
Manic Depressive Illness ◽  
X Linkage ◽  
Manic Depressive ◽  
Affected Parent ◽  
Additional Support ◽  
General Explanation

SummaryThirty years ago it was suggested that the apparently higher incidence of manic-depressive illness in women might be due to X-linked heredity. The hypothesis was undermined by subsequent reports of the frequent occurrence of father to son transmission. Winokur and his associates recently revived it, providing data which indicated that such transmission is absent or rare in the bipolar form of the illness. Additional support has come from linkage studies with known genetic markers located on the X chromosome. The present study, based on the 400 parents of 100 male and 100 female bipolar manic-depressive probands, failed to discover a lack of father-son compared to other affected parent-child pairs. This finding, together with a review of the literature, would indicate that it is premature to invoke X-linked heredity as a general explanation for bipolar manic-depressive illness, though there is mounting evidence that it may account for the illness in some family pedigrees.

Through the Looking Glass: A Psychologist's Experience of Depression

CNS Spectrums ◽  
1998 ◽  
Vol 3 (5) ◽  
pp. 38-47
Author(s):  
Martha Manning
Keyword(s):  
Mood Disorder ◽  
Psychiatric Illness ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Psychiatric Unit ◽  
The Past ◽  
Manic Depressive ◽  
The World ◽  
Looking Glass

Driving to the symposium, the vague anxiety and discomfort I had heen experiencing for the past few days finally culminated in the realization that 7 years ago that day, I awoke from my first night as an inpatient at a psychiatric unit.Since then and because of that, I've learned a great deal about depressive and manic-depressive illness. I've learned about stigma and shame. I've learned about the devastation that the violence we benignly call “mood disorder” wreaks on families. I have been awed by the array of treatments we've found to ease the suffering, and humbled by the fact that we still have a long way to go. I have become painfully aware of how unenlightened the world still is about psychiatric illness, and saddened by the cruel irony that the only thing more stigmatizing than suffering from a psychiatric illness is seeking treatment for it.

The Phenomenology of Bipolar I Manic-Depressive Illness

1982 ◽  
Vol 27 (2) ◽  
pp. 150-154 ◽  
Author(s):  
Lawrence G. Wilson ◽  
Norman E. Rosenthal ◽  
David L. Dunner
Keyword(s):  
Social Adjustment ◽  
Stressful Life Events ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Course Of Illness ◽  
The Past ◽  
Manic Depressive ◽  
Bipolar Patients ◽  
Psychotic Features

There have been several advances in the knowledge of the phenomenology of Bipolar Manic-Depressive Illness in the past decade. Studies of groups of carefully diagnosed bipolar patients have characterized features of the course of illness, the presence and prognostic influence of psychotic features, the influence of stressful life events, features of social adjustment and aspects of personality and long-term functioning. Similar studies of bipolar illness in non-western cultures would be of interest.

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