Comparison of the Prophylactic Action of Flupenthixol with Placebo in Lithium Treated Manic-Depressive Patients

1986 ◽  
Vol 148 (6) ◽  
pp. 723-725 ◽  
Author(s):  
J. Esparon ◽  
J. Kolloori ◽  
G. J. Naylor ◽  
A. M. McHarg ◽  
A. H. W. Smith ◽  
...  
Keyword(s):  
Prophylactic Effect ◽  
Double Blind ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Depressive Patients

A double-blind cross-over trial of depot flupenthixol in recurrent manic depressive psychosis was carried out. Ail patients continued on lithium. Eleven patients completed the two-year trial. Flupenthixol appeared to have no prophylactic effect.

A Genetic Study of Affective Illness in Patients over 50

1964 ◽  
Vol 110 (465) ◽  
pp. 244-254 ◽  
Author(s):  
G. Hopkinson
Keyword(s):  
General Population ◽  
Later Life ◽  
Manic Depressive Psychosis ◽  
Affective Illness ◽  
Manic Depressive ◽  
Increased Risk ◽  
Involutional Melancholia ◽  
Relationship Of ◽  
The Relationship ◽  
Depressive Patients

The genetic evidence concerning affective illness of later life is still conflicting and the relationship of such conditions to the manic-depressive psychosis unclear. Kallman (1955) believed that, genetically, involutional melancholia bore a closer relationship to schizophrenia than to the manic-depressive psychosis. An increased risk for schizophrenia amongst the relatives of such patients was not observed by Kay (1959) and Stenstedt (1952). Both these writers do however describe a lower loading for manic-depressive psychosis than would be found amongst the relations of manic-depressive patients, though a much higher incidence than in the general population. Both Stenstedt and Kay assumed that they were dealing with a heterogeneous group of patients containing both psychotic and neurotic depressions.

Controlled Studies of the Acute Antidepressant Effects of Lithium

1979 ◽  
Vol 135 (3) ◽  
pp. 255-262 ◽  
Author(s):  
E. P. Worrall ◽  
J. P. Moody ◽  
M. Peet ◽  
P. Dick ◽  
A. Smith ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Antidepressant Activity ◽  
Antidepressant Effect ◽  
Controlled Trials ◽  
Double Blind ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Antidepressant Effects

SummaryIn two randomized double-blind controlled trials on 63 depressed female in-patients subject to recurrent affective disorder (bipolar and unipolar manic-depressive psychosis) lithium was shown to have major acute antidepressant effects. At the end of three weeks lithium produced more uniform improvement than did imipramine; lithium in combination with tryptophan (in the form of Optimax) was superior to tryptophan alone—the latter drug having no discernible antidepressant activity in this group of patients.Lithium did not produce an antidepressant effect until the second and third week of both trials.

Renin and Aldosterone Relationships in Manic Depressive Psychosis

1977 ◽  
Vol 131 (6) ◽  
pp. 575-581 ◽  
Author(s):  
R. P. Hullin ◽  
T. C. Jerram ◽  
M. R. Lee ◽  
M. J. Levell ◽  
S. P. Tyrer
Keyword(s):  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Plasma Sodium ◽  
Primary Defect ◽  
Sodium Potassium ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Aldosterone Production ◽  
Depressive Patients

SUMMARY The paper describes a two-month period of study in four bipolar manic-depressive patients in a metabolic ward. Plasma renin activity, packed cell volume, plasma sodium and potassium were determined at intervals. Twenty-four-hour urinary sodium, potassium and creatinine were also estimated daily. Aldosterone production rate was measured on two occasions for each patient. Three of the patients showed at least one episode each of mania and depression during the study, while the fourth patient, who was receiving prophylactic lithium throughout, had one ten-day depressive episode but was otherwise normal.No obvious relationship between mood and plasma renin activity was observed, but the group showed a high resting renin activity, a blunted renin response to posture, and inappropriate aldosterone production rates for the renin activity found.It is postulated that a primary defect in the aldosterone-renin system may be present in bipolar manic-depressive psychosis.

The therapeutic effect of ascorbic acid and EDTA in manic-depressive psychosis: double-blind comparisons with standard treatments

1984 ◽  
Vol 14 (3) ◽  
pp. 533-539 ◽  
Author(s):  
D. S. G. Kay ◽  
G. J. Naylor ◽  
A. H. W. Smith ◽  
C. Greenwood
Keyword(s):  
Ascorbic Acid ◽  
Acetic Acid ◽  
Therapeutic Effect ◽  
Ethylene Diamine ◽  
Double Blind ◽  
Manic Depressive Psychosis ◽  
Treatment Regimes ◽  
Manic Depressive ◽  
Significant Difference ◽  
Manic Patients

SynopsisThe effect of ascorbic acid and ethylene diamine tetra acetic acid (EDTA) in the treatment of manic-depressive psychosis was compared, using double-blind procedures, with recognized treatment regimes. There was no significant difference between the response of depressed patients to amitriptyline or ascorbic acid and EDTA. Manic patients responded significantly better to lithium than to ascorbic acid and EDTA. These results are in keeping with the suggestion that vanadium may be of aetiological importance in depressive psychosis, but do not support such a suggestion for mania.

Daily variations of the urine content of 3-methoxy-4-hydroxyphenylglycol in two manic-depressive patients

1972 ◽  
Vol 2 (1) ◽  
pp. 81-85 ◽  
Author(s):  
P. A. Bond ◽  
F. A. Jenner ◽  
Gwyneth A. Sampson
Keyword(s):  
Noradrenaline Metabolism ◽  
Normal Range ◽  
Manic Depressive Psychosis ◽  
Daily Variations ◽  
Manic Depressive ◽  
Brain Noradrenaline ◽  
Depressive Patients

SYNOPSISDaily measurements of MHPG in urine have been carried out in two patients with manic-depressive psychosis. In both cases, levels in mania were elevated and in depression lowered with interval levels which were intermediate and within the normal range. The results lend some support to the suggestion that there might be an increase in brain noradrenaline metabolism in mania and a decrease in depression.

INHIBITION OF ALDOSTERONE PRODUCTION IN ADRENAL CELL SUSPENSIONS BY SERUM FROM PATIENTS WITH MANIC-DEPRESSIVE PSYCHOSIS

1979 ◽  
Vol 80 (1) ◽  
pp. 41-50 ◽  
Author(s):  
M. J. O'BRIEN ◽  
M. J. LEVELL ◽  
R. P. HULLIN
Keyword(s):  
Angiotensin Ii ◽  
Zona Glomerulosa ◽  
Serum Samples ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Aldosterone Production ◽  
Human Sera ◽  
Depressive Patients ◽  
Individual Human

A method of preparing a suspension of cells of the zona glomerulosa from rat adrenal capsules treated with crude collagenase is described. The cells responded to ACTH, angiotensin II and serotonin by increased production of aldosterone. Pooled human sera or individual human sera (from healthy normal or non-psychiatric in-patients) to a final concentration of 30% had no effect on ACTH-stimulated production of aldosterone. Many serum samples from five patients with manic-depressive psychosis, however, caused a reduction in aldosterone production; 65% of those samples taken during depression, 44% of the samples taken during manic episodes and 23% of the samples taken when the mood was normal. Sera from manic-depressive patients also reduced the production of aldosterone caused by angiotensin II or serotonin. This effect of serum from manic-depressives in vitro may be related to the abnormalities of aldosterone control in such patients.

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