Cerebral Ventricular Enlargement in Non-Genetic Schizophrenia: a Controlled Twin Study

1984 ◽  
Vol 144 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Adrianne M. Reveley ◽  
Michael A. Reveley ◽  
Robin M. Murray
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Normal Control ◽  
Twin Study ◽  
Ventricular Enlargement ◽  
Ventricular Size ◽  
Birth Complications ◽  
Twin Birth ◽  
Major Psychiatric Disorder ◽  
History Of

SummaryIn a group of schizophrenics of twin birth, no evidence of ventricular enlargement was found where there was a family history of major psychiatric disorder. Among those schizophrenics without such a family history, cerebral ventricular size was significantly increased (P <0.01), and there was also evidence of birth complications. Among normal control twins, those who reported complicated births had significantly larger ventricles.

Family History and Cerebral Ventricular Enlargement in Schizophrenia

1989 ◽  
Vol 154 (5) ◽  
pp. 629-634 ◽  
Author(s):  
Michael J. Owen ◽  
Shôn W. Lewis ◽  
Robin M. Murray
Keyword(s):  
Family History ◽  
Affective Disorder ◽  
Positive Family History ◽  
Ventricular Enlargement ◽  
Ventricular Size ◽  
Degree Relative ◽  
Distinct Subgroup ◽  
Schizophrenic Patients ◽  
History Of ◽  
Normal Controls

Ventricular size was measured from CT scans in 48 patients meeting RDC for schizophrenia who had a first-degree relative with a history of treatment for major psychiatric disorder, in 48 age- and sex-matched schizophrenic patients with no such history in first- or second-degree relatives, and in 48 matched, healthy controls. There was no difference in ventricular size between those with and without a positive family history, although both groups showed ventricular enlargement with respect to normal controls. Ventricular enlargement was demonstrated in the subgroup of 23 patients with a family history of schizophrenia, but not in the subgroup of 18 patients with a family history of affective disorder. These observations provide further evidence that schizophrenics with a family history of affective disorder may constitute an aetiologically distinct subgroup.

Obtaining a Family Psychiatric History: Is it Worth the Effort?

1993 ◽  
Vol 38 (9) ◽  
pp. 590-594 ◽  
Author(s):  
Ronald A. Remick ◽  
Adele D. Sadovnick ◽  
Boris Gimbarzevsky ◽  
Raymond W. Lam ◽  
Athanasios P. Zis ◽  
...  
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Medical Records ◽  
Psychiatric History ◽  
First Degree Relatives ◽  
History Of ◽  
Generated Family ◽  
Index Cases

The purpose of this study was to determine whether, for first-degree relatives of patients presenting to a mood disorders clinic, family history information on psychiatric conditions collected by a psychiatrist and incorporated into the patient's medical records is as informative as that gathered during an interview specifically designed to collect family history data. The study group consisted of 472 first-degree relatives of 78 randomly selected index cases from a large mood disorders genetic database. Family history of psychiatric disorders recorded in regular psychiatric medical records (“clinician history”), and data obtained by a genetic counsellor administering specific family psychiatric history questionnaires to patients and multiple family informants (“family history”) were compared using a kappa statistic. Good agreement between the two methods on the presence or absence of a psychiatric disorder was found among first-degree relatives of index cases, but poor agreement was found with respect to the presence or absence of a specific mood disorder diagnosis(es) in a relative. The results suggest that a clinician-generated family psychiatric history is sensitive to the presence or absence of a psychiatric disorder when compared to a more structured detailed genetic interview. However, for research purposes, a clinician-generated family psychiatric history of a specific mood disorder diagnosis, without supporting collateral information, may not be reliable for use in supporting a mood disorder diagnosis in a patient and/or his relatives.

Sporadic Pick's Disease in a 28-Year-Old Woman

1993 ◽  
Vol 162 (2) ◽  
pp. 259-262 ◽  
Author(s):  
H. Rana Mowadat ◽  
E. E. Kerr ◽  
D. Stclair
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Neurodegenerative Disorders ◽  
Young Patients ◽  
Initial Diagnosis ◽  
Cognitive Testing ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Functional Psychosis ◽  
History Of

Pick's disease was diagnosed in a 28-year-old woman without a family history of dementia (or other psychiatric disorder), after an initial diagnosis of functional psychosis and management with ECT and neuroleptics. The case illustrates the need for detailed neurological and cognitive testing and consideration of neurodegenerative disorders even in young patients.

Ventricular Enlargement in Schizophrenia

1985 ◽  
Vol 147 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Michael A. Reveley
Keyword(s):  
Ct Scans ◽  
Ventricular Enlargement ◽  
Ventricular Size ◽  
Validity And Reliability ◽  
Computerised Tomography ◽  
Twin Birth ◽  
Chronic Schizophrenics ◽  
Level Of Significance ◽  
Considerable Range ◽  
Age And Sex

SummaryThere has been a considerable range in both the prevalence of ventricular enlargement and values for ventricular size of both schizophrenics and controls, in studies using computerised tomography (CT). The CT scans of 19 unrelated chronic schizophrenics, all of monozygotic (MZ) twin birth, and 36 age-and-sex-matched normal twins from 18 MZ pairs were examined by linear, planimetric, and semi-automated computerised methods. All methods distinguished schizophrenics from controls at approximately the same level of significance, but partial volume artefact led to a greater than two-fold variation in apparent ventricular size, and significantly reduced the validity and reliability of mechanical planimetric and linear measures. Measurement error may be an important source of artefact in uncontrolled studies using those techniques, and when comparing absolute values across studies, but the use of computerised methods should significantly reduce this source of artefact and allow more meaningful comparison.

The Association Between Triple X and Psychosis

1992 ◽  
Vol 160 (4) ◽  
pp. 554-557 ◽  
Author(s):  
Wendy J. Woodhouse ◽  
Anthony J. Holland ◽  
Greg McLean ◽  
Adrianne M. Reveley
Keyword(s):  
British Journal ◽  
Family History ◽  
Psychiatric Disorder ◽  
Obstetric Complications ◽  
Psychiatric Practice ◽  
Psychotic Illness ◽  
Chromosome Anomalies ◽  
Eeg Abnormalities ◽  
Management Problems ◽  
History Of

Two cases of psychotic illness in association with the karyotype triple X showed specific diagnostic and management problems as well as obstetric complications, EEG abnormalities, and lack of a family history of psychiatric disorder. Routine karyotyping during the investigation of psychosis is becoming relevant to psychiatric practice as research reports increasingly feature genetic and chromosome anomalies in association with schizophrenic psychoses.British Journal of Psychiatry (1992), 160, 554–557

scholarly journals Suicide attempts by jumping

1998 ◽  
Vol 22 (7) ◽  
pp. 424-427 ◽  
Author(s):  
John Joyce ◽  
Simon Fleminger
Keyword(s):  
Psychiatric Disorder ◽  
Suicide Attempts ◽  
Psychological Morbidity ◽  
Suicidal Intent ◽  
National Statistics ◽  
Major Psychiatric Disorder ◽  
Poor Outcome ◽  
History Of ◽  
High Level

Those who attempt suicide by jumping often have a history of major psychiatric disorder, are left with a high level of physical and psychological morbidity and have a poor outcome. Services are failing this group in that national statistics may underestimate its size, and even when patients are in contact and are symptomatic and expressing suicidal intent before the incident many go on to jump. Care in hospital and preparation for follow up is uncoordinated.

P.1.064 Antidepressant theraphy response and age, number of episodes, duration of episodes, and family history of psychiatric disorder

1997 ◽  
Vol 7 ◽  
pp. S155
Author(s):  
Selçuk Kirli ◽  
Cengiz Güleç ◽  
Levent Küey ◽  
Mehmet Bekaroǧlu ◽  
Yunus E. Evlice ◽  
...  
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
History Of

Psychiatric Aspects of Narcolepsy

1976 ◽  
Vol 128 (6) ◽  
pp. 562-565 ◽  
Author(s):  
Alec Roy
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Social Life ◽  
Personal History ◽  
Sexual Disorder ◽  
History Of ◽  
A Current

SummaryAmong twenty patients with narcolepsy intelligence was normal and no characteristic personality or psychopathology was found. A family history of psychiatric disorder was present in five and a past personal history in ten. Eight had a current psychiatric disorder and twelve either a current or past psychiatric disorder. Chronic sexual disorder was present in eleven. Arousal appeared to be the mechanism by which emotions precipitated symptoms. Ten patients were found to have had difficulties at work, in marriage or in social life.

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