The Association Between Triple X and Psychosis

1992 ◽  
Vol 160 (4) ◽  
pp. 554-557 ◽  
Author(s):  
Wendy J. Woodhouse ◽  
Anthony J. Holland ◽  
Greg McLean ◽  
Adrianne M. Reveley
Keyword(s):  
British Journal ◽  
Family History ◽  
Psychiatric Disorder ◽  
Obstetric Complications ◽  
Psychiatric Practice ◽  
Psychotic Illness ◽  
Chromosome Anomalies ◽  
Eeg Abnormalities ◽  
Management Problems ◽  
History Of

Two cases of psychotic illness in association with the karyotype triple X showed specific diagnostic and management problems as well as obstetric complications, EEG abnormalities, and lack of a family history of psychiatric disorder. Routine karyotyping during the investigation of psychosis is becoming relevant to psychiatric practice as research reports increasingly feature genetic and chromosome anomalies in association with schizophrenic psychoses.British Journal of Psychiatry (1992), 160, 554–557

Obstetric Complications, the Putative Familial-Sporadic Distinction, and Tardive Dyskinesia in Schizophrenia

1990 ◽  
Vol 157 (4) ◽  
pp. 578-584 ◽  
Author(s):  
Eadbhard O'Callaghan ◽  
Conall Larkin ◽  
Anthony Kinsella ◽  
John L. Waddington
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Tardive Dyskinesia ◽  
Genetic Factors ◽  
Cognitive Deficit ◽  
Obstetric Complications ◽  
History Of ◽  
Schizophrenic Outpatients

Obstetric complications were more common in the histories of those schizophrenic outpatients without a family history of psychiatric disorder, and were associated with an earlier onset of their illness. Those patients with tardive dyskinesia were more likely to have a family history of psychiatric disorder, less likely to have experienced obstetric complications, and showed greater cognitive deficit. Obstetric complications should be considered in juxtaposition with genetic factors in evaluating the putative familial-sporadic distinction in schizophrenia. Additionally, familial/genetic factors appear to contribute to vulnerability to tardive dyskinesia.

Obtaining a Family Psychiatric History: Is it Worth the Effort?

1993 ◽  
Vol 38 (9) ◽  
pp. 590-594 ◽  
Author(s):  
Ronald A. Remick ◽  
Adele D. Sadovnick ◽  
Boris Gimbarzevsky ◽  
Raymond W. Lam ◽  
Athanasios P. Zis ◽  
...  
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Medical Records ◽  
Psychiatric History ◽  
First Degree Relatives ◽  
History Of ◽  
Generated Family ◽  
Index Cases

The purpose of this study was to determine whether, for first-degree relatives of patients presenting to a mood disorders clinic, family history information on psychiatric conditions collected by a psychiatrist and incorporated into the patient's medical records is as informative as that gathered during an interview specifically designed to collect family history data. The study group consisted of 472 first-degree relatives of 78 randomly selected index cases from a large mood disorders genetic database. Family history of psychiatric disorders recorded in regular psychiatric medical records (“clinician history”), and data obtained by a genetic counsellor administering specific family psychiatric history questionnaires to patients and multiple family informants (“family history”) were compared using a kappa statistic. Good agreement between the two methods on the presence or absence of a psychiatric disorder was found among first-degree relatives of index cases, but poor agreement was found with respect to the presence or absence of a specific mood disorder diagnosis(es) in a relative. The results suggest that a clinician-generated family psychiatric history is sensitive to the presence or absence of a psychiatric disorder when compared to a more structured detailed genetic interview. However, for research purposes, a clinician-generated family psychiatric history of a specific mood disorder diagnosis, without supporting collateral information, may not be reliable for use in supporting a mood disorder diagnosis in a patient and/or his relatives.

Sporadic Pick's Disease in a 28-Year-Old Woman

1993 ◽  
Vol 162 (2) ◽  
pp. 259-262 ◽  
Author(s):  
H. Rana Mowadat ◽  
E. E. Kerr ◽  
D. Stclair
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Neurodegenerative Disorders ◽  
Young Patients ◽  
Initial Diagnosis ◽  
Cognitive Testing ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Functional Psychosis ◽  
History Of

Pick's disease was diagnosed in a 28-year-old woman without a family history of dementia (or other psychiatric disorder), after an initial diagnosis of functional psychosis and management with ECT and neuroleptics. The case illustrates the need for detailed neurological and cognitive testing and consideration of neurodegenerative disorders even in young patients.

scholarly journals Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies

2017 ◽  
Vol 7 (4) ◽  
pp. 141-157 ◽  
Author(s):  
Rafael G. dos Santos ◽  
José Carlos Bouso ◽  
Jaime E. C. Hallak
Keyword(s):  
Systematic Review ◽  
Family History ◽  
Adverse Reactions ◽  
Population Studies ◽  
Case Reports ◽  
Case Series ◽  
Lysergic Acid ◽  
Psychotic Illness ◽  
History Of ◽  
Low Incidence

Ayahuasca is a hallucinogen brew traditionally used for ritual and therapeutic purposes in Northwestern Amazon. It is rich in the tryptamine hallucinogens dimethyltryptamine (DMT), which acts as a serotonin 5-HT2A agonist. This mechanism of action is similar to other compounds such as lysergic acid diethylamide (LSD) and psilocybin. The controlled use of LSD and psilocybin in experimental settings is associated with a low incidence of psychotic episodes, and population studies corroborate these findings. Both the controlled use of DMT in experimental settings and the use of ayahuasca in experimental and ritual settings are not usually associated with psychotic episodes, but little is known regarding ayahuasca or DMT use outside these controlled contexts. Thus, we performed a systematic review of the published case reports describing psychotic episodes associated with ayahuasca and DMT intake. We found three case series and two case reports describing psychotic episodes associated with ayahuasca intake, and three case reports describing psychotic episodes associated with DMT. Several reports describe subjects with a personal and possibly a family history of psychosis (including schizophrenia, schizophreniform disorders, psychotic mania, psychotic depression), nonpsychotic mania, or concomitant use of other drugs. However, some cases also described psychotic episodes in subjects without these previous characteristics. Overall, the incidence of such episodes appears to be rare in both the ritual and the recreational/noncontrolled settings. Performance of a psychiatric screening before administration of these drugs, and other hallucinogens, in controlled settings seems to significantly reduce the possibility of adverse reactions with psychotic symptomatology. Individuals with a personal or family history of any psychotic illness or nonpsychotic mania should avoid hallucinogen intake.

P.1.064 Antidepressant theraphy response and age, number of episodes, duration of episodes, and family history of psychiatric disorder

1997 ◽  
Vol 7 ◽  
pp. S155
Author(s):  
Selçuk Kirli ◽  
Cengiz Güleç ◽  
Levent Küey ◽  
Mehmet Bekaroǧlu ◽  
Yunus E. Evlice ◽  
...  
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
History Of

Schizophrenics with a family history of bipolar disorder. Possible involvement of obstetric complications

1993 ◽  
Vol 8 (4) ◽  
pp. 223-226
Author(s):  
H Verdoux ◽  
M Bourgeois
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Case Reports ◽  
Obstetric Complications ◽  
Schizophrenic Patients ◽  
History Of ◽  
The Continuum

SummaryThe case reports of two DSM III-R schizophrenic patients with a family history of bipolar disorder are presented. The two patients had a history of severe obstetric complications (OCs). These cases are discussed in the light of neurodevelopmental theories of schizophrenia and in the continuum view of psychosis.

scholarly journals Association of family history of schizophrenia and history of obstetric complications at birth: relationship with age at onset and psychopathology dimensions in a Nigerian cohort

2020 ◽  
Vol 20 (2) ◽  
pp. 697-708
Author(s):  
Justus Uchenna Onu ◽  
Jude Uzoma Ohaeri
Keyword(s):  
Risk Factor ◽  
Family History ◽  
Independent Risk Factor ◽  
Age At Onset ◽  
Obstetric Complications ◽  
Symptom Dimensions ◽  
Clinical Phenotypes ◽  
The Family ◽  
Psychopathological Symptom ◽  
History Of

Background: The nature of the association between obstetric complications (OCs) at birth and the genetic aetiology of schizo- phrenia remains unclear, as some authors suggest that it is an independent risk factor while others support either interactionism or an epiphenomenon perspective. Objective: To examine the association of family history of schizophrenia (FHS) with history of OCs, with a view to assessing whether this relationship moderates clinical phenotypes such as symptom dimensions and age at onset of illness. Methods: This study examined OCs among schizophrenia probands using the Obstetric Complications Scale. An inquiry into family history was performed using the Family history method. Psychopathological symptom dimensions were assessed using standard scales. Data were analyzed to examine the interaction of FHS and history of OCs with age at onset and symptom dimensions, using ANCOVA. Results: FHS was significantly associated with the disorganized symptoms dimension (p=0.03). History of OCs was significant- ly associated with earlier age at onset (p=0.007). However, in ANCOVA, the effect of the interaction between FHS and history of OCs was not significant for age at onset and symptom dimensions (P = 0.059). Conclusion: FHS was significantly associated with disorganization syndrome, and OCs was significantly associated with age at onset. Keywords: Family history; schizophrenia; obstetric complications; symptom dimensions; age at onset.

The phenomenology and diagnosis of psychiatric illness in people with Prader–Willi syndrome

2008 ◽  
Vol 38 (10) ◽  
pp. 1505-1514 ◽  
Author(s):  
S. Soni ◽  
J. Whittington ◽  
A. J. Holland ◽  
T. Webb ◽  
E. N. Maina ◽  
...  
Keyword(s):  
Family History ◽  
Affective Disorder ◽  
Psychiatric Illness ◽  
Uniparental Disomy ◽  
Psychotic Symptoms ◽  
Chromosome 15 ◽  
Prader Willi Syndrome ◽  
Psychotic Illness ◽  
Genetic Subtype ◽  
History Of

BackgroundPsychotic illness is strongly associated with the maternal uniparental disomy (mUPD) genetic subtype of Prader–Willi syndrome (PWS), but not the deletion subtype (delPWS). This study investigates the clinical features of psychiatric illness associated with PWS. We consider possible genetic and other mechanisms that may be responsible for the development of psychotic illness, predominantly in those with mUPD.MethodThe study sample comprised 119 individuals with genetically confirmed PWS, of whom 46 had a history of psychiatric illness. A detailed clinical and family psychiatric history was obtained from these 46 using the PAS-ADD, OPCRIT, Family History and Life Events Questionnaires.ResultsIndividuals with mUPD had a higher rate of psychiatric illness than those with delPWS (22/34 v. 24/85, p<0.001). The profile of psychiatric illness in both genetic subtypes resembled an atypical affective disorder with or without psychotic symptoms. Those with delPWS were more likely to have developed a non-psychotic depressive illness (p=0.005) and those with mUPD a bipolar disorder with psychotic symptoms (p=0.00005). Individuals with delPWS and psychotic illness had an increased family history of affective disorder. This was confined exclusively to their mothers.ConclusionsPsychiatric illness in PWS is predominately affective with atypical features. The prevalence and possibly the severity of illness are greater in those with mUPD. We present a ‘two-hit’ hypothesis, involving imprinted genes on chromosome 15, for the development of affective psychosis in people with PWS, regardless of genetic subtype.

Sign in / Sign up

Export Citation Format

Share Document