Platelet Serotonin of Hyperactive School Age Boys

1974 ◽  
Vol 125 (585) ◽  
pp. 138-140 ◽  
Author(s):  
Judith L. Rapoport ◽  
Patricia Quinn ◽  
Nina Scribanu ◽  
Dennis L. Murphy
Keyword(s):  
Whole Blood ◽  
School Functioning ◽  
School Age ◽  
Urinary Catecholamine ◽  
Serotonin Content ◽  
Biochemical Effects ◽  
Platelet Serotonin ◽  
Hyperactive Children ◽  
Indoleamine Metabolism

It has repeatedly been demonstrated that hyperactive children improve in behaviour and school functioning when treated with amphetamine, methylphenidate and, according to recent studies, imipramine (Conners, 1972). While these drugs affect catecholamine and indoleamine metabolism, there have been few studies intercorrelating the clinical and biochemical effects of these agents. A small number of untreated hyperactive children have been found to have normal urinary catecholamine and indoleamine excretion (Rapoport et al., 1970; Wender, 1971) although whole blood hydroxyindole concentrations have been reported as reduced (Coleman, 1971). In the present study, platelet serotonin content was examined before and during treatment with methylphenidate and imipramine of a group of boys with the hyperactivity syndrome.

Desmopressin Induces Decrease in Platelet Serotonin Content in Uremia

1989 ◽  
Vol 61 (03) ◽  
pp. 537-537 ◽  
Author(s):  
J Matyszko ◽  
M H Pietraszek ◽  
A Azzadin ◽  
W Buczko ◽  
M Myśliwiec
Keyword(s):  
Serotonin Content ◽  
Platelet Serotonin

Non-Thrombogenicity of Clean Glass Revealed by Native Whole Blood Assay in Bead Columns

1983 ◽  
Vol 50 (04) ◽  
pp. 814-820 ◽  
Author(s):  
J A Bergeron ◽  
J M DiNovo ◽  
A F Razzano ◽  
W J Dodds
Keyword(s):  
Whole Blood ◽  
Glass Bead ◽  
Factor Xii ◽  
Platelet Factor ◽  
Serotonin Content ◽  
Whole Blood Assay ◽  
Vascular Integrity ◽  
Blood Assay ◽  
Standard Contact ◽  
Recalcification Time

SummaryThe previously described native whole blood assay for materials in solution or suspension has been adapted to materials in a bead column configuration. These experiments showed that the glass itself accounts for little or none of the high blood-reactivity observed with conventional glass bead columns. Columns composed solely of soft glass that was “cleaned” by heat treatment (500-595° C 18 hr, electric oven) were benign toward flowing native whole blood for all variables measured (platelet count and platelet-free plasma [C14]-serotonin content, platelet factor 3 and factor XII activities, and recalcification time) with the standard contact protocol. In addition, the effluent successfully maintained perfusion of the isolated kidney, a measure of the ability of platelets to support vascular integrity. Prolonged (30 min) normothermic contact with titrated whole blood increased the subsequent reactivity of initially clean glass toward whole blood albeit to a level much less than that of conventional glass bead columns.

Improved Diagnosis of Carcinoid Tumors by Measurement of Platelet Serotonin

1992 ◽  
Vol 38 (4) ◽  
pp. 534-540 ◽  
Author(s):  
I P Kema ◽  
E G de Vries ◽  
A M Schellings ◽  
P E Postmus ◽  
F A Muskiet
Keyword(s):  
Carcinoid Tumors ◽  
Fluorometric Detection ◽  
Complementary Information ◽  
Serotonin Content ◽  
Platelet Serotonin ◽  
Serotonin Secretion ◽  
Hydroxyindoleacetic Acid ◽  
Plasma Serotonin ◽  
Term Monitoring

Abstract Carcinoid patients are diagnosed biochemically on the basis of increased urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA); urinary and platelet serotonin concentrations are considered to provide complementary information. Using established HPLC methods with fluorometric detection, we evaluated the clinical usefulness of measurements of urinary 5-HIAA and urinary, plasma, and platelet serotonin in 30 consecutive patients with histologically proven carcinoid tumors of fore-, mid-, and hindgut origin before treatment. Ten patients showed no signs of serotonin overproduction; 14 had increased concentrations of urinary 5-HIAA and platelet serotonin; and platelet serotonin, but not urinary 5-HIAA, was increased in 6. None had increased urinary 5-HIAA excretion without an increase in platelet serotonin content. In cases with high rates of tumor serotonin secretion, platelet serotonin reached a maximum and did not correlate with serotonin secretion rate, whereas urinary 5-HIAA was correlated. Increased platelet serotonin was correlated with increased plasma serotonin and with occurrence of carcinoid syndrome. Increased urinary serotonin, allegedly caused by increases in circulating 5-hydroxytryptophan, almost invariably coincided with increased platelet serotonin, but not necessarily with above-normal urinary 5-HIAA excretion. From these results and long-term monitoring of three patients during treatment, we conclude that platelet serotonin is more sensitive than urinary 5-HIAA for detecting carcinoids that secrete only small amounts of serotonin.

scholarly journals School maturity of pre-school age visually impaired children

2015 ◽  
Vol 3 ◽  
pp. 33
Author(s):  
Vytautas Gudonis
Keyword(s):  
Visually Impaired ◽  
Motor Coordination ◽  
School Education ◽  
School Age ◽  
Visual Motor Coordination ◽  
Number Of Children ◽  
Hyperactive Children ◽  
Visual Motor ◽  
Impaired Children ◽  
Visually Impaired Children

The sample or research is 310 pre-school age visually impaired children. The average age of the surveyed is 6.3 years, the sharpness of vision is V 0.3–1. The research employed the methods for assessment of children’s maturity for school worked out by G. Gintilienė, D. Butkienė, S. Girdzijauskienė et al. (2005). During the investigation, essential problems of pre-school age visually impaired children have been estimated: a number of hyperactive children increases; also, a number of children who can hardly focus and retain attention increases; poor visual-motor coordination; narrow vocabulary; they explain notions of active vocabulary with difficulty. Results of school maturity of pre-school age visually impaired children proved significance of pre-school education institutions in visually impaired children’s preparation for school. It has been found that when surveying children of pre-school groups twice, in September and May, as well as preparing and using psychologists’ recommendations for pedagogues and parents, the level of pupils’ school maturity increases.

Platelet serotonin content and free and total plasma tryptophan in healthy volunteers during 24 hours

1993 ◽  
Vol 39 (11) ◽  
pp. 2337-2340 ◽  
Author(s):  
N Eynard ◽  
E Flachaire ◽  
C Lestra ◽  
M Broyer ◽  
R Zaidan ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Healthy Volunteers ◽  
Psychiatric Disorders ◽  
Hplc Method ◽  
Total Plasma ◽  
Circadian Variations ◽  
Serotonin Content ◽  
Plasma Tryptophan ◽  
Platelet Serotonin

Abstract The determination of platelet serotonin (5-HT) and plasma tryptophan concentrations is useful in the diagnosis, investigation of etiologies, and treatment of psychiatric disorders. To determine the usual circadian variations in platelet 5-HT and free and total tryptophan concentrations, we measured these variables during 24 h at 1-h intervals and every 30 min from 2000 to 0800 in seven clinically healthy young men with an HPLC method. No common circadian rhythm for platelet serotonin concentrations was observed in our subjects; however, there was a distinct rhythm for both free and total plasma tryptophan: Concentrations were maximal in the afternoon and minimal during the night.

scholarly journals Platelet Serotonin Content and Transpulmonary Platelet Serotonin Gradient in Patients with Pulmonary Hypertension

Respiration ◽  
2011 ◽  
Vol 81 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Silvia Ulrich ◽  
Lars C. Huber ◽  
Manuel Fischler ◽  
Ursula Treder ◽  
Marco Maggiorini ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Serotonin Content ◽  
Platelet Serotonin

Platelet Serotonin Levels in Hyperactive Children

1979 ◽  
Vol 4 (3) ◽  
pp. 285-296 ◽  
Author(s):  
Janice O. Goldman ◽  
Roger J. Thibert ◽  
Byron P. Rourke
Keyword(s):  
Platelet Serotonin ◽  
Hyperactive Children
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