scholarly journals Platelet Serotonin Content and Transpulmonary Platelet Serotonin Gradient in Patients with Pulmonary Hypertension

Respiration ◽  
2011 ◽  
Vol 81 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Silvia Ulrich ◽  
Lars C. Huber ◽  
Manuel Fischler ◽  
Ursula Treder ◽  
Marco Maggiorini ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Serotonin Content ◽  
Platelet Serotonin

Desmopressin Induces Decrease in Platelet Serotonin Content in Uremia

1989 ◽  
Vol 61 (03) ◽  
pp. 537-537 ◽  
Author(s):  
J Matyszko ◽  
M H Pietraszek ◽  
A Azzadin ◽  
W Buczko ◽  
M Myśliwiec
Keyword(s):  
Serotonin Content ◽  
Platelet Serotonin

Improved Diagnosis of Carcinoid Tumors by Measurement of Platelet Serotonin

1992 ◽  
Vol 38 (4) ◽  
pp. 534-540 ◽  
Author(s):  
I P Kema ◽  
E G de Vries ◽  
A M Schellings ◽  
P E Postmus ◽  
F A Muskiet
Keyword(s):  
Carcinoid Tumors ◽  
Fluorometric Detection ◽  
Complementary Information ◽  
Serotonin Content ◽  
Platelet Serotonin ◽  
Serotonin Secretion ◽  
Hydroxyindoleacetic Acid ◽  
Plasma Serotonin ◽  
Term Monitoring

Abstract Carcinoid patients are diagnosed biochemically on the basis of increased urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA); urinary and platelet serotonin concentrations are considered to provide complementary information. Using established HPLC methods with fluorometric detection, we evaluated the clinical usefulness of measurements of urinary 5-HIAA and urinary, plasma, and platelet serotonin in 30 consecutive patients with histologically proven carcinoid tumors of fore-, mid-, and hindgut origin before treatment. Ten patients showed no signs of serotonin overproduction; 14 had increased concentrations of urinary 5-HIAA and platelet serotonin; and platelet serotonin, but not urinary 5-HIAA, was increased in 6. None had increased urinary 5-HIAA excretion without an increase in platelet serotonin content. In cases with high rates of tumor serotonin secretion, platelet serotonin reached a maximum and did not correlate with serotonin secretion rate, whereas urinary 5-HIAA was correlated. Increased platelet serotonin was correlated with increased plasma serotonin and with occurrence of carcinoid syndrome. Increased urinary serotonin, allegedly caused by increases in circulating 5-hydroxytryptophan, almost invariably coincided with increased platelet serotonin, but not necessarily with above-normal urinary 5-HIAA excretion. From these results and long-term monitoring of three patients during treatment, we conclude that platelet serotonin is more sensitive than urinary 5-HIAA for detecting carcinoids that secrete only small amounts of serotonin.

Platelet Serotonin of Hyperactive School Age Boys

1974 ◽  
Vol 125 (585) ◽  
pp. 138-140 ◽  
Author(s):  
Judith L. Rapoport ◽  
Patricia Quinn ◽  
Nina Scribanu ◽  
Dennis L. Murphy
Keyword(s):  
Whole Blood ◽  
School Functioning ◽  
School Age ◽  
Urinary Catecholamine ◽  
Serotonin Content ◽  
Biochemical Effects ◽  
Platelet Serotonin ◽  
Hyperactive Children ◽  
Indoleamine Metabolism

It has repeatedly been demonstrated that hyperactive children improve in behaviour and school functioning when treated with amphetamine, methylphenidate and, according to recent studies, imipramine (Conners, 1972). While these drugs affect catecholamine and indoleamine metabolism, there have been few studies intercorrelating the clinical and biochemical effects of these agents. A small number of untreated hyperactive children have been found to have normal urinary catecholamine and indoleamine excretion (Rapoport et al., 1970; Wender, 1971) although whole blood hydroxyindole concentrations have been reported as reduced (Coleman, 1971). In the present study, platelet serotonin content was examined before and during treatment with methylphenidate and imipramine of a group of boys with the hyperactivity syndrome.

Platelet serotonin content and free and total plasma tryptophan in healthy volunteers during 24 hours

1993 ◽  
Vol 39 (11) ◽  
pp. 2337-2340 ◽  
Author(s):  
N Eynard ◽  
E Flachaire ◽  
C Lestra ◽  
M Broyer ◽  
R Zaidan ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Healthy Volunteers ◽  
Psychiatric Disorders ◽  
Hplc Method ◽  
Total Plasma ◽  
Circadian Variations ◽  
Serotonin Content ◽  
Plasma Tryptophan ◽  
Platelet Serotonin

Abstract The determination of platelet serotonin (5-HT) and plasma tryptophan concentrations is useful in the diagnosis, investigation of etiologies, and treatment of psychiatric disorders. To determine the usual circadian variations in platelet 5-HT and free and total tryptophan concentrations, we measured these variables during 24 h at 1-h intervals and every 30 min from 2000 to 0800 in seven clinically healthy young men with an HPLC method. No common circadian rhythm for platelet serotonin concentrations was observed in our subjects; however, there was a distinct rhythm for both free and total plasma tryptophan: Concentrations were maximal in the afternoon and minimal during the night.

Relationship between platelet serotonin content and rejections of unfair offers in the ultimatum game

2008 ◽  
Vol 437 (2) ◽  
pp. 158-161 ◽  
Author(s):  
Enzo Emanuele ◽  
Natascia Brondino ◽  
Marco Bertona ◽  
Simona Re ◽  
Diego Geroldi
Keyword(s):  
Ultimatum Game ◽  
Serotonin Content ◽  
Platelet Serotonin

scholarly journals Assessment of Platelet and Plasma Serotonin in Canine Pulmonary Hypertension Secondary to Degenerative Mitral Valve Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Nattawan Tangmahakul ◽  
Pussadee Makoom ◽  
Sirilak Disatian Surachetpong
Keyword(s):  
Pulmonary Hypertension ◽  
Mitral Valve ◽  
Mitral Valve Disease ◽  
High Probability ◽  
Valve Disease ◽  
Serotonin Concentration ◽  
Platelet Serotonin ◽  
The Difference ◽  
Post Hoc ◽  
Plasma Serotonin

Background: Pulmonary hypertension (PH) is a common complication of degenerative mitral valve disease (DMVD), the most common cardiovascular disease in dogs. Serotonin has been suspected to play a role in the pathogenesis of PH, so this study aimed to investigate the differences in platelet and plasma serotonin between normal, DMVD and DMVD with PH (DMVD+PH) dogs.Materials and Methods: Sixty-two small-breed dogs were enrolled to the study and divided into the normal (n = 22), DMVD (n = 20), and DMVD+PH (n = 20) groups. The platelet and plasma serotonin concentrations were measured by the competitive ELISA.Results: The Kruskal–Wallis revealed the difference among the four groups of normal (179.73 [102.37–352.24] ng/109 platelets), DMVD (325.99 [96.84–407.66] ng/109 platelets), DMVD with intermediate probability of PH (291.11 [106.69–400.84] ng/109 platelets) and DMVD with high probability of PH (35.82 [2.69–126.35] ng/109 platelets) (p = 0.014). The Dunn's post-hoc test showed a decrease in the platelet serotonin concentration of the DMVD dogs with high probability of PH compared to the DMVD group (p = 0.008). The plasma serotonin concentration was not different between normal, DMVD, and DMVD+PH dogs.Conclusion: In conclusion, a decrease in platelet serotonin concentration, which is associated with a degree of PH probability was found in DMVD dogs with PH. Further studies investigating roles of platelet serotonin in PH secondary to DMVD should be performed.

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