Manic-Depressive Psychosis and Urinary Excretion of Cyclic AMP

1972 ◽  
Vol 121 (561) ◽  
pp. 236-237 ◽  
Author(s):  
F. A. Jenner ◽  
Gwyneth A. Sampson ◽  
Elizabeth A. Thompson ◽  
A. R. Somerville ◽  
Nicol A. Beard ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Manic Depressive Psychosis ◽  
Manic Depressive

Urinary Excretion of Cyclic Amp and Manic-Depressive Psychosis

1972 ◽  
Vol 120 (557) ◽  
pp. 405-408 ◽  
Author(s):  
B. L. Brown ◽  
J. G. Salway ◽  
J. D. M. Albano ◽  
R. P. Hullin ◽  
R. P. Ekins
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Affective Disorders ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Normal Subjects ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Mental Symptoms ◽  
Manic Patients

Recently several communications have been published implicating impaired 3′5′ cyclic adenosine monophosphate (cyclic AMP) metabolism as a causal factor in affective disorders (1, 3, 7, 8, 9, 11). In particular, the urinary excretion of cyclic AMP in manic patients is reported to be increased compared with that of normal subjects, whereas in depressed patients a decreased excretion has been observed (1, 7, 8, 9). These findings form the basis of a theory explaining the systemic and mental symptoms of affective disorders (1).

Urinary Cyclic AMP in the Switch Process from Depression to Mania

1974 ◽  
Vol 125 (588) ◽  
pp. 457-458 ◽  
Author(s):  
R. P. Hullin ◽  
J. G. Salway ◽  
M. N. E. Allsopp ◽  
Janet D. M. Albano ◽  
G. Dawn Barnes ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Bipolar Patient ◽  
Transient Increase ◽  
Short Cycle ◽  
General Lack ◽  
Mood Changes ◽  
Manic Depressive ◽  
Urinary Cyclic Amp ◽  
Depressive Patients

Various reports have suggested that the urinary excretion of adenosine cyclic 3'5’ monophosphate (cyclic AMP) is increased in mania and decreased in depression. However, our own serial studies from short-cycle bipolar manic-depressive patients showed no correlation between mood and cyclic AMP excretion (2). Jenner et al. (4) confirmed our findings, except in the case of a patient with a regular 48-hour mood cycle who did show a correlation between his mood changes and changes in cyclic AMP excretion. Paul et al. (5) also reported a general lack of correlation between these variables, but found a transient increase of urinary cyclic AMP during the rapid switch from depression to mania. We have investigated the situation in a bipolar patient who shows such a rapid switch in mood but have been unable to demonstrate any increase in cyclic AMP excretion during the switch period.

Urinary Excretion of Adenosine 3’: 5′-Cyclic Monophosphate in Depressive Illness

1974 ◽  
Vol 125 (586) ◽  
pp. 275-279 ◽  
Author(s):  
Graham J. Naylor ◽  
David A. Stansfield ◽  
Susan F. Whyte ◽  
Frederick Hutchinson
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Affective State ◽  
Depressive Illness ◽  
Control Group ◽  
Cyclic Monophosphate ◽  
Manic Depressive ◽  
Two Samples ◽  
Urinary Cyclic Amp ◽  
Depressive Patients

Changes in the excretion of adenosine 3’:5′-cyclic monophosphate (cyclic AMP) have been reported in depressive illness. Abdulla and Hamadah (1970) reported that urinary cyclic AMP excretion was lower than normal during depression and increased with recovery. However, these results were based on single 24-hour urine collections during depression and on recovery, with no creatinine estimations to suggest that the collections were complete. There was no control of diet, drugs or activity. The controls do not appear to have been matched for age. Paul, Ditzion, Pauk and Janowsky (1970) reported that the cyclic AMP excretion in neurotic depression was higher and in psychotic depression was lower than in a control group, but neither difference was statistically significant. However, on enlarging the study by including more psychotic depressives they reported that the cyclic AMP excretion of this group was significantly less than that of the controls (Paul, Cramer and Goodwin, 1971). These workers had controlled the patients' drug and dietary (but not fluid) intake. There appeared to be only minimal control of activity. The results were based on approximately two samples of urine per subject, which were very carefully checked for completeness of collection. Unfortunately the age of the controls (19–22 years) was very different from that of the patients (25–64 years). On two small groups of patients treated with either Laevodopa or lithium carbonate, they reported that changes in affective state were accompanied by changes in the urinary excretion of cyclic AMP. However, in serial studies on manic-depressive patients Paul, Cramer and Bunney (1971) failed to show a correlation between mood rating and cyclic AMP excretion in five out of seven patients; but they reported that the cyclic AMP excretion was increased on the day of rapid switch from depression to mania. The above groups of workers had used an enzymatic-isotope displacement technique to estimate the cyclic AMP. Brown, Salway, Albano, Hullin and Ekins (1972), using a saturation method to assay cyclic AMP, found no correlation between mood and cyclic AMP excretion in two short-cycle manic-depressive patients. Jenner, Sampson, Thompson, Somerville, Beard and Smith (1972) wrote: ‘We have measured daily excretion by a number of depressed and manic depressive patients over periods covering several mood changes without being able to establish any consistent correlation between cyclic AMP excretion and mood, … However, in one unusual case we have found a very marked correlation‘. We (Naylor, Dick, Dick, Moody and Stansfield, 1974) were unable to demonstrate any relationship between urinary cyclic AMP excretion and mood in a patient with recurrent psychotic episodes, in which depressive features predominated.

Manic-Depressive Psychosis: An Alternative Conceptual Model

1968 ◽  
Vol 114 (517) ◽  
pp. 1523-1530 ◽  
Author(s):  
J.H. Court
Keyword(s):  
Conceptual Model ◽  
Human Behaviour ◽  
Biological Cycle ◽  
Traditional Concept ◽  
Manic Depressive Psychosis ◽  
Manic Depressive

The traditional concept of manic-depressive psychosis has been either a bi-polar or a circular one, used interchangeably. The psychoanalytic school has invoked the polarity of much of human behaviour as an appropriate analogy. For example “The tragedy is succeeded by the satyr play: after the serious worship of God comes the merry fair… On the same basis the same sequence is represented by the cycle of guilt feelings and unscrupulousness, later by the sequence of guilt feelings and forgiveness…. The manic-depressive cycle is a cycle between periods of increased and decreased guilt feelings: … this cycle, in the last analysis, goes back to the biological cycle of hunger and satiety in the infant” (Fenichel, 1946, p. 409).

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