Normothymotics, “Mood-Normalizers”

1963 ◽  
Vol 109 (463) ◽  
pp. 803-809 ◽  
Author(s):  
Mogens Schou
Keyword(s):  
Clinical Psychiatry ◽  
Affective Disorders ◽  
Psychopathological Symptoms ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Mental Diseases ◽  
Drug Compounds ◽  
Almost All

The action of almost all drugs used so far in psychiatric pharmacotherapy has been directed against psychopathological symptoms or syndromes and not against mental diseases as such, the nosological entities defined by classical clinical psychiatry. In this paper the attention will be drawn towards a different type of drug: compounds with an action specific to a disease rather than to a symptom, and evidence will be presented for the existence within this class of a group that is characterized by being active against affective disorders (manic-depressive psychosis).Normothymotics, “mood-normalizers”, is proposed as a collective name for drugs belonging to this group.

scholarly journals Some problematic and discussion issues of psychosomatic relationships and somatoform disorders from the standpoint of clinical psychiatry

2018 ◽  
pp. 80-89 ◽  
Author(s):  
S. V. Litvintsev
Keyword(s):  
Clinical Psychiatry ◽  
Psychosomatic Medicine ◽  
Clinical Picture ◽  
Somatoform Disorders ◽  
Separate Group ◽  
Psychosomatic Disorders ◽  
Psychopathological Symptoms ◽  
Rehabilitation Programs ◽  
Mental Diseases ◽  
Icd 10

A brief historical digression into the doctrine of psychosomatics and the establishment of the term «psychosomatic medicine» are represented in the article. Some views on the formation and systematization of psychosomatic disorders are examined. The scientific grounds for isolating somatoform disorders into a separate group and their inclusion in the modern classifications of mental diseases (DSM and ICD-10) are analyzed. It is stated that the clinical picture of somatoform disorders does not contain specific psychopathological symptoms and syndromes but mostly consists of disparate symptom complexes, and this fact puts a question of the place of this pathology in psychiatric nosology. It is suggested that further research by experts from different fields of science should lead to the science-based principles for delineating the clinical boundaries of somatoform disorders at an interdisciplinary level that will allow developing valid therapeutic and rehabilitation programs for this group of patients.

Vanilmandelicaciduria in the Different Clinical Phases of Manic Depressive Psychosis

1970 ◽  
Vol 116 (533) ◽  
pp. 435-436 ◽  
Author(s):  
Tito Campanini ◽  
Alberto Catalano ◽  
Carlo De Risio ◽  
Giacomo Mardighian
Keyword(s):  
Affective Disorders ◽  
Adrenergic Receptor ◽  
Manic Depressive Psychosis ◽  
Relative Decrease ◽  
Manic Depressive ◽  
Receptor Sites

The catecholamine hypothesis of affective disorders proposes that 'some-if not all-depressions are associated with an absolute or relative decrease in catecholamines, particularly norepinephrine, available at central adrenergic receptor sites. Elation, conversely, may be associated with an excess of such amines' (Schildkraut, 1965).

Genetical Analysis of Unipolar and Bipolar Endogenous Affective Psychoses

1977 ◽  
Vol 131 (5) ◽  
pp. 478-485 ◽  
Author(s):  
Olga Trzebiatowska-Trzeciak
Keyword(s):  
Affective Disorders ◽  
Unipolar Depression ◽  
Genetical Analysis ◽  
Polygenic Inheritance ◽  
Affective Psychoses ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Morbidity Risk ◽  
Second Degree

The mode of inheritance of affective psychoses was studied in 800 first degree and 582 second degree relatives of 122 probands. Morbidity risk for unipolar depression was 12·0±3·2 and 11·4±2·7 per cent respectively for parents and siblings of probands suffering from unipolar depression. Morbidity risk for manic-depressive psychosis for the respective groups of first degree relatives of manic-depressive probands was 15·1±3·2 and 16·9±3·2 per cent. In second degree relatives the morbidity risk was 3·4±1·0 and 5·3±1·4 per cent for unipolar depression and manic-depressive psychosis respectively.The results indicate the role of genetical factors in the etiology of both types of affective disorder and show that unipolar depression and manic-depressive psychosis are distinct entities. The hypothesis of X-linked dominant transmission was not confirmed in either of these affective disorders. By means of the computational model of Slater, no results compatible with a polygenic inheritance of unipolar depression or manic-depressive psychosis were found.

Urinary Excretion of Cyclic Amp and Manic-Depressive Psychosis

1972 ◽  
Vol 120 (557) ◽  
pp. 405-408 ◽  
Author(s):  
B. L. Brown ◽  
J. G. Salway ◽  
J. D. M. Albano ◽  
R. P. Hullin ◽  
R. P. Ekins
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Affective Disorders ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Normal Subjects ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Mental Symptoms ◽  
Manic Patients

Recently several communications have been published implicating impaired 3′5′ cyclic adenosine monophosphate (cyclic AMP) metabolism as a causal factor in affective disorders (1, 3, 7, 8, 9, 11). In particular, the urinary excretion of cyclic AMP in manic patients is reported to be increased compared with that of normal subjects, whereas in depressed patients a decreased excretion has been observed (1, 7, 8, 9). These findings form the basis of a theory explaining the systemic and mental symptoms of affective disorders (1).

A comparison of ICD-8 and ICD-10 diagnoses of affective disorder - a case register study from Denmark

1998 ◽  
Vol 13 (7) ◽  
pp. 342-345 ◽  
Author(s):  
LV Kessing
Keyword(s):  
Personality Disorders ◽  
Affective Disorder ◽  
Clinical Psychiatry ◽  
Affective Disorders ◽  
Register Study ◽  
Case Register ◽  
Psychiatric Admissions ◽  
Manic Depressive ◽  
Icd 10 ◽  
Diagnostic Concordance

SummaryThe introduction of ICD-10 has changed the diagnostic borders of affective disorders in clinical psychiatry. The current study presents the diagnostic concordance between ICD-8 diagnoses given in 1993 and ICD-10 diagnoses given in 1994 to the same patients admitted in both years, according to the Danish register of psychiatric admissions. In total, 1,487 patients received an ICD-8 diagnosis of manicdepressive psychoses in 1993 and were re-admitted in 1994. The majority of patients (84.0%) with a manic-depressive diagnosis according to ICD-8 received a diagnosis of affective disorder according to ICD-10. Patients with a diagnosis of affective disorder according to ICD-10 had previously been diagnosed as manic-depressive (69.6%), psychogenic psychoses (8.7%). personality disorders (5.5%) or neurosis (3.2%) according to ICD-8. The ICD-10 concept of affective disorder thus appeared broader and more comprehensive compared with ICD-8.

Sign in / Sign up

Export Citation Format

Share Document