Glucocorticoid-induced TNF receptor family gene (GITR) knockout mice exhibit a resistance to splanchnic artery occlusion (SAO) shock

2004 ◽  
Vol 76 (5) ◽  
pp. 933-940 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Giuseppe Nocentini ◽  
Rosanna Di Paola ◽  
Emanuela Mazzon ◽  
Simona Ronchetti ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Artery Occlusion ◽  
Tnf Receptor ◽  
Splanchnic Artery ◽  
Family Gene ◽  
Tnf Receptor Family ◽  
Receptor Family

Role of glucocorticoid‐induced TNF receptor family gene (GITR) in collagen‐induced arthritis

2005 ◽  
Vol 19 (10) ◽  
pp. 1253-1265 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Emira Ayroldi ◽  
Rosanna Di Paola ◽  
Massimiliano Agostini ◽  
Emanuela Mazzon ◽  
...  
Keyword(s):  
Tnf Receptor ◽  
Collagen Induced Arthritis ◽  
Family Gene ◽  
Tnf Receptor Family ◽  
Receptor Family

The T-Cell Activation Markers CD30 and OX40/CD134 Are Expressed in Nonoverlapping Subsets of Peripheral T-Cell Lymphoma

Blood ◽  
1999 ◽  
Vol 93 (10) ◽  
pp. 3487-3493 ◽  
Author(s):  
Dan Jones ◽  
Christopher D.M. Fletcher ◽  
Karen Pulford ◽  
Aliakbar Shahsafaei ◽  
David M. Dorfman
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Lymphoma ◽  
Large Cell ◽  
T Cell Lymphoma ◽  
Tnf Receptor ◽  
T Cell Lymphomas ◽  
Tumor Types ◽  
Tnf Receptor Family ◽  
Receptor Family

The tumor necrosis factor (TNF) receptor family includes several important markers of activation in T cells. We examined expression patterns of two T-cell-associated members of these receptors, namely CD30 and OX40/CD134, in 148 cases of T-cell lymphoma to identify possible objective immunohistochemical criteria for subclassification of these tumors. CD30 expression was characteristic of tumors with an anaplastic (46/47 cases [98%]) or large-cell (10/21 [48%]) morphology and was seen in only scattered cells in other tumor types. In contrast, large numbers of OX40/CD134+ tumors cells were typical of angioimmunoblastic lymphoma (15/16 [94%]), angiocentric lymphoma (4/4), a subset of large-cell lymphomas (10/21 [48%]), and lymphomas with a prominent histiocytic component (6/7 [86%]). Strong OX40/CD134 and CD30 coexpression was seen in only 4% of tumors, typically those with an anaplastic/Hodgkin’s-like appearance. OX40/CD134 expression was characteristic of tumors composed of activated CD4+ T cells and was not seen in small-cell T-cell lymphomas, lymphoblastic lymphomas, or other tumor types, including B-cell lymphomas or carcinomas. These results suggest that immunostaining for OX40/CD134 may be helpful in subclassification of peripheral T-cell lymphomas and that the patterns of TNF receptor family expression in these tumors may parallel those seen within nonneoplastic helper T-cell subsets.

scholarly journals The glucocorticoid-induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in mice

2011 ◽  
Vol 162 (5) ◽  
pp. 1186-1201 ◽  
Author(s):  
M Galuppo ◽  
G Nocentini ◽  
E Mazzon ◽  
S Ronchetti ◽  
E Esposito ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Tnf Receptor ◽  
Related Protein ◽  
Tnf Receptor Family ◽  
Receptor Family

scholarly journals A Novel TNF Receptor Family Member Binds TWEAK and Is Implicated in Angiogenesis

Immunity ◽  
2001 ◽  
Vol 15 (5) ◽  
pp. 837-846 ◽  
Author(s):  
Steven R Wiley ◽  
Linda Cassiano ◽  
Timothy Lofton ◽  
Terry Davis-Smith ◽  
Jeffrey A Winkles ◽  
...  
Keyword(s):  
Family Member ◽  
Tnf Receptor ◽  
Tnf Receptor Family ◽  
Receptor Family

scholarly journals A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors

Neuron ◽  
2005 ◽  
Vol 45 (5) ◽  
pp. 815
Author(s):  
Jong Bae Park ◽  
Glenn Yiu ◽  
Shinjiro Kaneko ◽  
Jing Wang ◽  
Jufang Chang ◽  
...  
Keyword(s):  
Family Member ◽  
Inhibitory Activity ◽  
Tnf Receptor ◽  
Nogo Receptor ◽  
Tnf Receptor Family ◽  
Receptor Family

A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGF/TNF receptor family

Gene ◽  
1995 ◽  
Vol 164 (2) ◽  
pp. 311-315 ◽  
Author(s):  
Morey Setareh ◽  
Herbert Schwarz ◽  
Martin Lotz
Keyword(s):  
Soluble Form ◽  
Tnf Receptor ◽  
Mrna Variant ◽  
Tnf Receptor Family ◽  
Receptor Family

Modulation of cord blood CD8+ T-cell effector differentiation by TGF-β1 and 4-1BB costimulation

Blood ◽  
2005 ◽  
Vol 105 (1) ◽  
pp. 274-281 ◽  
Author(s):  
Young-June Kim ◽  
Teresa M. Stringfield ◽  
Yan Chen ◽  
Hal E. Broxmeyer
Keyword(s):  
T Cells ◽  
T Cell ◽  
Immune Responses ◽  
Cord Blood ◽  
Cd8 T Cells ◽  
Cytotoxic T Cell ◽  
Tnf Receptor ◽  
Tnf Receptor Family ◽  
Tgf Β1 ◽  
Receptor Family

Abstract Transforming growth factor-β1 (TGF-β1), an immunosuppressive cytokine, inhibits cytotoxic T cell (CTL) immune responses. In contrast, 4-1BB (CD137), a costimulatory molecule in the tumor necrosis factor (TNF) receptor family, amplifies CTL-mediated antitumor immune responses. We investigated whether TGF-β1 responses could be reversed by 4-1BB costimulation during in vitro differentiation of naive CD8+ T cells into effector CTL cells. TGF-β1 potently suppressed CTL differentiation of human cord blood naive CD8+ T cells as determined by reduced induction of characteristic phenotypes of effector cells and cytotoxic activity. TGF-β1-mediated suppression of CTL differentiation was abrogated by 4-1BB costimulation but not by CD28 or another member in the TNF receptor family, CD30. 4-1BB costimulation suppressed Smad2 phosphorylation induced by TGF-β1, suggesting that 4-1BB effects were at the level of TGF-β1 signaling. 4-1BB effects on the TGF-β1-mediated suppression were enhanced by interleukin 12 (IL-12) but counteracted by IL-4; 4-1BB expression was up- or down-regulated, respectively, by IL-12 and IL-4. IL-4 was more dominant than IL-12 when both cytokines were present during 4-1BB costimulation in the presence of TGF-β1. This indicates critical roles for IL-4 and IL-12 in regulating 4-1BB effects on TGF-β1-mediated suppression. (Blood. 2005;105:274-281)

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