Role of glucocorticoid‐induced TNF receptor family gene (GITR) in collagen‐induced arthritis

2005 ◽  
Vol 19 (10) ◽  
pp. 1253-1265 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Emira Ayroldi ◽  
Rosanna Di Paola ◽  
Massimiliano Agostini ◽  
Emanuela Mazzon ◽  
...  
Keyword(s):  
Tnf Receptor ◽  
Collagen Induced Arthritis ◽  
Family Gene ◽  
Tnf Receptor Family ◽  
Receptor Family

scholarly journals Role of ADAM10 and ADAM17 in Regulating CD137 Function

2021 ◽  
Vol 22 (5) ◽  
pp. 2730
Author(s):  
Jana Seidel ◽  
Sinje Leitzke ◽  
Björn Ahrens ◽  
Maria Sperrhacke ◽  
Sucharit Bhakdi ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Soluble Form ◽  
Tnf Receptor ◽  
Anoctamin 6 ◽  
Phospholipid Scramblase ◽  
Potential Impact ◽  
A Disintegrin And Metalloproteinase ◽  
Tnf Receptor Family ◽  
Receptor Family

Human CD137 (4-1BB), a member of the TNF receptor family, and its ligand CD137L (4-1BBL), are expressed on immune cells and tumor cells. CD137/CD137L interaction mediates bidirectional cellular responses of potential relevance in inflammatory diseases, autoimmunity and oncology. A soluble form of CD137 exists, elevated levels of which have been reported in patients with rheumatoid arthritis and various malignancies. Soluble CD137 (sCD137) is considered to represent a splice variant of CD137. In this report, however, evidence is presented that A Disintegrin and Metalloproteinase (ADAM)10 and potentially also ADAM17 are centrally involved in its generation. Release of sCD137 by transfected cell lines and primary T cells was uniformly inhibitable by ADAM10 inhibition. The shedding function of ADAM10 can be blocked through inhibition of its interaction with surface exposed phosphatidylserine (PS), and this effectively inhibited sCD137 generation. The phospholipid scramblase Anoctamin-6 (ANO6) traffics PS to the outer membrane and thus modifies ADAM10 function. Overexpression of ANO6 increased stimulated shedding, and hyperactive ANO6 led to maximal constitutive shedding of CD137. sCD137 was functionally active and augmented T cell proliferation. Our findings shed new light on the regulation of CD137/CD137L immune responses with potential impact on immunotherapeutic approaches targeting CD137.

Glucocorticoid-induced TNF receptor family gene (GITR) knockout mice exhibit a resistance to splanchnic artery occlusion (SAO) shock

2004 ◽  
Vol 76 (5) ◽  
pp. 933-940 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Giuseppe Nocentini ◽  
Rosanna Di Paola ◽  
Emanuela Mazzon ◽  
Simona Ronchetti ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Artery Occlusion ◽  
Tnf Receptor ◽  
Splanchnic Artery ◽  
Family Gene ◽  
Tnf Receptor Family ◽  
Receptor Family

The T-Cell Activation Markers CD30 and OX40/CD134 Are Expressed in Nonoverlapping Subsets of Peripheral T-Cell Lymphoma

Blood ◽  
1999 ◽  
Vol 93 (10) ◽  
pp. 3487-3493 ◽  
Author(s):  
Dan Jones ◽  
Christopher D.M. Fletcher ◽  
Karen Pulford ◽  
Aliakbar Shahsafaei ◽  
David M. Dorfman
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Lymphoma ◽  
Large Cell ◽  
T Cell Lymphoma ◽  
Tnf Receptor ◽  
T Cell Lymphomas ◽  
Tumor Types ◽  
Tnf Receptor Family ◽  
Receptor Family

The tumor necrosis factor (TNF) receptor family includes several important markers of activation in T cells. We examined expression patterns of two T-cell-associated members of these receptors, namely CD30 and OX40/CD134, in 148 cases of T-cell lymphoma to identify possible objective immunohistochemical criteria for subclassification of these tumors. CD30 expression was characteristic of tumors with an anaplastic (46/47 cases [98%]) or large-cell (10/21 [48%]) morphology and was seen in only scattered cells in other tumor types. In contrast, large numbers of OX40/CD134+ tumors cells were typical of angioimmunoblastic lymphoma (15/16 [94%]), angiocentric lymphoma (4/4), a subset of large-cell lymphomas (10/21 [48%]), and lymphomas with a prominent histiocytic component (6/7 [86%]). Strong OX40/CD134 and CD30 coexpression was seen in only 4% of tumors, typically those with an anaplastic/Hodgkin’s-like appearance. OX40/CD134 expression was characteristic of tumors composed of activated CD4+ T cells and was not seen in small-cell T-cell lymphomas, lymphoblastic lymphomas, or other tumor types, including B-cell lymphomas or carcinomas. These results suggest that immunostaining for OX40/CD134 may be helpful in subclassification of peripheral T-cell lymphomas and that the patterns of TNF receptor family expression in these tumors may parallel those seen within nonneoplastic helper T-cell subsets.

scholarly journals The glucocorticoid-induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in mice

2011 ◽  
Vol 162 (5) ◽  
pp. 1186-1201 ◽  
Author(s):  
M Galuppo ◽  
G Nocentini ◽  
E Mazzon ◽  
S Ronchetti ◽  
E Esposito ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Tnf Receptor ◽  
Related Protein ◽  
Tnf Receptor Family ◽  
Receptor Family

scholarly journals A Novel TNF Receptor Family Member Binds TWEAK and Is Implicated in Angiogenesis

Immunity ◽  
2001 ◽  
Vol 15 (5) ◽  
pp. 837-846 ◽  
Author(s):  
Steven R Wiley ◽  
Linda Cassiano ◽  
Timothy Lofton ◽  
Terry Davis-Smith ◽  
Jeffrey A Winkles ◽  
...  
Keyword(s):  
Family Member ◽  
Tnf Receptor ◽  
Tnf Receptor Family ◽  
Receptor Family

scholarly journals A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors

Neuron ◽  
2005 ◽  
Vol 45 (5) ◽  
pp. 815
Author(s):  
Jong Bae Park ◽  
Glenn Yiu ◽  
Shinjiro Kaneko ◽  
Jing Wang ◽  
Jufang Chang ◽  
...  
Keyword(s):  
Family Member ◽  
Inhibitory Activity ◽  
Tnf Receptor ◽  
Nogo Receptor ◽  
Tnf Receptor Family ◽  
Receptor Family
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