scholarly journals Some Effects of Gram-negative Bacterial Endotoxin and its Importance as a Contaminator of Biological Preparations

1989 ◽  
Vol 31 (2) ◽  
pp. 193-206 ◽  
Author(s):  
Chahna R. Yagoda ◽  
Ann-Christin Bylund-Fellenius ◽  
Hans Kindahl
Keyword(s):  
Bacterial Endotoxin ◽  
Gram Negative

Gram-negative periodontal pathogens and bacterial endotoxin in metallic orthodontic brackets with or without an antimicrobial agent: An in-vivo study

2011 ◽  
Vol 140 (6) ◽  
pp. e281-e287 ◽  
Author(s):  
Paulo Nelson-Filho ◽  
Remberto Marcelo Argandoña Valdez ◽  
Marcela Cristina Damião Andrucioli ◽  
Maria Conceição Pereira Saraiva ◽  
Magda Feres ◽  
...  
Keyword(s):  
Antimicrobial Agent ◽  
Orthodontic Brackets ◽  
Bacterial Endotoxin ◽  
In Vivo Study ◽  
Periodontal Pathogens ◽  
Gram Negative

Cotton dust and gram-negative bacterial endotoxin correlations in two cotton textile mills

1993 ◽  
Vol 23 (2) ◽  
pp. 333-342 ◽  
Author(s):  
David C. Christiani ◽  
David H. Wegman ◽  
Ellen A. Eisen ◽  
Ting-Ting Ye ◽  
Pei-Lian Lu ◽  
...  
Keyword(s):  
Bacterial Endotoxin ◽  
Cotton Textile ◽  
Cotton Dust ◽  
Textile Mills ◽  
Gram Negative

scholarly journals Endotoxins from a Pharmacopoeial Point of View

Toxins ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 331 ◽  
Author(s):  
Elvira Franco ◽  
Verónica Garcia-Recio ◽  
Pilar Jiménez ◽  
Manuel Garrosa ◽  
Tomás Girbés ◽  
...  
Keyword(s):  
United States ◽  
Intravenous Administration ◽  
Point Of View ◽  
Bacterial Endotoxin ◽  
Gram Negative ◽  
Similarities And Differences ◽  
Pharmaceutical Laboratories

A pyrogen is a substance that causes fever after intravenous administration or inhalation. Gram negative endotoxins are the most important pyrogens to pharmaceutical laboratories. In the International, United States, Japanese and European Pharmacopoeias, there are two official methods to evaluate pyrogenicitythat is, the bacterial endotoxin test, and the pyrogen test. The main objective of this review is to compare the monographs of each test among the different Pharmacopeias, to detect similarities and differences. The former can be considered fully harmonized, and only non-significant differences were detected. The latter, which is the only available assay for some products and formulations to demonstrate apyrogenicity, shows large differences, which should be considered.

scholarly journals Cardiovascular and Metabolic Effects of Whole or Fractionated Gram-Negative Bacterial Endotoxin in the Unanesthetized Rhesus Monkey

1973 ◽  
Vol 33 (3) ◽  
pp. 346-352 ◽  
Author(s):  
MICHAEL J. REICHGOTT ◽  
KENNETH L. MELMON ◽  
RALPH P. FORSYTH ◽  
DIRK GREINEDER
Keyword(s):  
Rhesus Monkey ◽  
Bacterial Endotoxin ◽  
Metabolic Effects ◽  
Gram Negative

scholarly journals Metabolic Fingerprinting of Feces from Calves, Subjected to Gram-Negative Bacterial Endotoxin

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 108
Author(s):  
Saeid Kamel Oroumieh ◽  
Abbas Ali Naserian ◽  
Lieven Van Meulebroek ◽  
Ellen De Paepe ◽  
Reza Valizadeh ◽  
...  
Keyword(s):  
Fish Oil ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Disease Diagnosis ◽  
Bacterial Endotoxin ◽  
P Value ◽  
Gram Negative ◽  
Beneficial Effects ◽  
Lps Challenge ◽  
Before And After

Gram-negative bacteria have a well-known impact on the disease state of neonatal calves and their mortality. This study was the first to implement untargeted metabolomics on calves’ fecal samples to unravel the effect of Gram-negative bacterial endotoxin lipopolysaccharide (LPS). In this context, calves were challenged with LPS and administered with fish oil, nanocurcumin, or dexamethasone to evaluate treatment effects. Ultra-high-performance liquid-chromatography high-resolution mass spectrometry (UHPLC-HRMS) was employed to map fecal metabolic fingerprints from the various groups before and after LPS challenge. Based on the generated fingerprints, including 9650 unique feature ions, significant separation according to LPS group was achieved through orthogonal partial least squares discriminant analysis (Q2 of 0.57 and p-value of 0.022), which allowed the selection of 37 metabolites as bacterial endotoxin markers. Tentative identification of these markers suggested that the majority belonged to the subclass of the carboxylic acid derivatives—amino acids, peptides, and analogs—and fatty amides, with these subclasses playing a role in the metabolism of steroids, histidine, glutamate, and folate. Biological interpretations supported the revealed markers’ potential to aid in disease diagnosis, whereas beneficial effects were observed following dexamethasone, fish oil, and nanocurcumin treatment.

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