Ultrasound protocols to measure carotid intima–media thickness: a post-hoc analysis of the OPAL study

2008 ◽  
Vol 25 (1) ◽  
pp. 109-122 ◽  
Author(s):  
S. Dogan ◽  
Y. Plantinga ◽  
G. W. Evans ◽  
R. Meijer ◽  
D. E. Grobbee ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Post Hoc Analysis ◽  
Media Thickness ◽  
Post Hoc

scholarly journals Endothelial Dysfunction, a Marker of Atherosclerosis, Is Independent of Metabolic Syndrome in NAFLD Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Jimmy Narayan ◽  
Haribhakti Seba Das ◽  
Preetam Nath ◽  
Ayaskanta Singh ◽  
Debakanta Mishra ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cardiac Events ◽  
Post Hoc Analysis ◽  
Media Thickness ◽  
Flow Mediated Dilatation ◽  
Post Hoc

Background. The study was designed to assess cardiovascular risk factors flow-mediated dilatation % (FMD%) and carotid intima-media thickness (CIMT) in NAFLD. Methods. 126 NAFLD subjects and 31 chronic hepatitis B (CHB) controls were studied. Measuring carotid intima-media thickness (CIMT) and the flow-mediated dilatation % (FMD%) by brachial artery Doppler ultrasound were used to assess atherosclerosis. The risk of cardiac events at 10 years (ROCE 10) was estimated by the Prospective Cardiovascular Munster Study (PROCAM) score. Results. 58 of 126 NAFLD have coexistent metabolic syndrome. Mean CIMT was 0.73±0.041 mm among NAFLD with MS, 0.66±0.016 mm among NAFLD without MS, and 0.66±0.037 in controls CHB patients. FMD% in NAFLD with MS was 10.43±3.134%, but was 8.56±3.581% in NAFLD without MS and 17.78±6.051% in controls. PROCAM score of NAFLD with MS was 46.95±6.509 while in NAFLD without MS was 38.2±3.738. Controls had a PROCAM score of 38.13±5.755. ROCE 10 in NAFLD with MS was 13.64±8.568 while NAFLD without MS was 5.55±1.949. Controls have a ROCE 10 of 5.95±3.973. Post hoc analysis showed CIMT was dependent upon MS while FMD% was different between all subgroups hence independent of metabolic syndrome. Conclusion. The markers of endothelial dysfunction are significantly higher in patients with NAFLD than controls.

scholarly journals Carotid Intima Media Thickness in Nondiabetic Hypertensive Nigerians: Role of Fasting and Postprandial Blood Glucose

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
B. N. Okeahialam ◽  
S. A. Muoneme ◽  
H. O. Kolade-Yunusa
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Intima Media Thickness ◽  
Threshold Level ◽  
Carotid Intima Media Thickness ◽  
Postprandial Blood Glucose ◽  
Atherosclerotic Vascular Disease ◽  
Media Thickness ◽  
Significant Difference ◽  
Post Hoc

Background/Aims. Carotid intima media thickness (CIMT) tracks atherosclerotic vascular disease. Hypertension and diabetes chiefly contribute to atherosclerosis with 75% of symptomatic cardiovascular disease cases having dysglycaemia even in normal cases. Hypothesising that postprandial hyperglycaemia contributes to cardiovascular morbidity, we sought to determine if any relationship existed between glycaemic profile in nondiabetic hypertensives and atherosclerosis.Methods. In a study of CIMT in nondiabetic, statin-naïve hypertensives, we evaluated fasting blood glucose (FBG) and 2-hour postprandial sugar (2hPPBG) in the patients and compared them with the CIMT. CIMT was measured on both sides, 1 cm proximal to the carotid bulb using a 7.5 mHz transducer of ALOKA SSD-3500 ultrasound machine.Results. The subjects with complete data were 86 (63 F). The mean (SD) of CIMT was 0.89 (0.15) mm, FBG 4.8 (0.097) mmol/L, and 2hPPBG 6.5 (1.81) mmol/L. There was no significant correlation between FBG and 2hPPBG with CIMT. Blood pressure had no bearing on this. When blood glucose data were divided into quartiles and post hoc multiple comparison was done, there was significant difference in CIMT for the different ranges. This was not so for 2hPPBG.Conclusion. Though expected from other studies, we did not show any significant correlation between FBG and 2hPPBG status and CIMT. This may be our pattern as the degree of excursion of 2hPPBG was low. There may be a threshold level above which PPBG starts to impact CIMT.

Correlation of Serum Sclerostin Levels with Carotid Intima Media Thickness in Chronic Kidney Disease Hemodialysis

2020 ◽  
Vol 6 (1) ◽  
pp. 18-26
Author(s):  
Adhi Permana ◽  
Ian Effendi ◽  
Taufik Indrajaya
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Calcification ◽  
Ultrasound Examination ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
The Mean ◽  
Sclerostin Level ◽  
Hemodialysis Duration

Chronic kidney disease is associated with a high mortality rate, especially cardiovascular disease associated with mineral and bone disorders. Sclerostin is an inhibitor of Wnt signaling which has the effect of increasing the occurrence of vascular calcification in patients with chronic kidney disease. There are several studies that show different results. Carotid intima media thickness ultrasound examination is a tool to identify atherosclerosis which is part of vascular calcification. The aim of this study is to look at the correlation of sclerostin with carotid intima media thickness (CIMT) in patients with chronic kidney disease undergoing hemodialysis. In this cross section, the concentration of sclerostin was measured by examination of enzymed linked immunosorbent assay. CIMT measurement by ultrasound mode B examination. There were 40 patients in this study. The mean sclerostin level was 256.68 ± 127.76 pg / ml. Sclerostin levels are declared high if above 162 pg / ml there are 30 people. CIMT thickening was present in 11 patients. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis (r-0.32 p0,847). In multivariate linear regression, hemodialysis duration is an independent factor that is significantly significant with CIMT. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis.

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