scholarly journals Endothelial Dysfunction, a Marker of Atherosclerosis, Is Independent of Metabolic Syndrome in NAFLD Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Jimmy Narayan ◽  
Haribhakti Seba Das ◽  
Preetam Nath ◽  
Ayaskanta Singh ◽  
Debakanta Mishra ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cardiac Events ◽  
Post Hoc Analysis ◽  
Media Thickness ◽  
Flow Mediated Dilatation ◽  
Post Hoc

Background. The study was designed to assess cardiovascular risk factors flow-mediated dilatation % (FMD%) and carotid intima-media thickness (CIMT) in NAFLD. Methods. 126 NAFLD subjects and 31 chronic hepatitis B (CHB) controls were studied. Measuring carotid intima-media thickness (CIMT) and the flow-mediated dilatation % (FMD%) by brachial artery Doppler ultrasound were used to assess atherosclerosis. The risk of cardiac events at 10 years (ROCE 10) was estimated by the Prospective Cardiovascular Munster Study (PROCAM) score. Results. 58 of 126 NAFLD have coexistent metabolic syndrome. Mean CIMT was 0.73±0.041 mm among NAFLD with MS, 0.66±0.016 mm among NAFLD without MS, and 0.66±0.037 in controls CHB patients. FMD% in NAFLD with MS was 10.43±3.134%, but was 8.56±3.581% in NAFLD without MS and 17.78±6.051% in controls. PROCAM score of NAFLD with MS was 46.95±6.509 while in NAFLD without MS was 38.2±3.738. Controls had a PROCAM score of 38.13±5.755. ROCE 10 in NAFLD with MS was 13.64±8.568 while NAFLD without MS was 5.55±1.949. Controls have a ROCE 10 of 5.95±3.973. Post hoc analysis showed CIMT was dependent upon MS while FMD% was different between all subgroups hence independent of metabolic syndrome. Conclusion. The markers of endothelial dysfunction are significantly higher in patients with NAFLD than controls.

scholarly journals Vascular function long term after Kawasaki disease: another piece of the puzzle?

2016 ◽  
Vol 27 (3) ◽  
pp. 488-497 ◽  
Author(s):  
Fátima F. Pinto ◽  
Inês Gomes ◽  
Petra Loureiro ◽  
Sérgio Laranjo ◽  
Ana T. Timóteo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endothelial Dysfunction ◽  
Kawasaki Disease ◽  
Vascular Function ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cardiac Complications ◽  
Media Thickness ◽  
Coronary Lesions

AbstractBackgroundKawasaki disease is an acute systemic vasculitis. Cardiac complications are frequent and include endothelial dysfunction in patients with coronary anomalies. Thus far, endothelial dysfunction in patients with no coronary lesions is poorly understood. Our aim was to access the vascular function in adolescents and young adults long term after Kawasaki disease, but without coronary aneurysms or any other cardiac risk factors.MethodsWe carried out a single-centre prospective study in a Portuguese population. We evaluated two groups of subjects: (1) Kawasaki disease patients over 11 years of age, diagnosed >5 years ago, with no coronary lesions or any other risk factors for cardiovascular disease; (2) control group of individuals without cardiovascular risk factors. Patients and controls were clinically assessed. Endo-PAT and carotid intima-media thickness assessment were performed to determine vascular function.ResultsIn total, 43 Kawasaki disease patients were assessed and compared with 43 controls. Kawasaki disease patients presented a decreased reactive hyperaemia index compared with controls (1.59±0.45 versus 1.98±0.41; p<0.001). Augmentation index was similar in both groups (−4.5±7 versus −5±9%; p 0.6). The mean carotid intima-media thickness was not significantly increased in the Kawasaki disease group. There were no statistically significant changes with regard to laboratory data.ConclusionsChildren with Kawasaki disease may have long-term sequelae, even when there is no discernible coronary artery involvement in the acute stage of the disease. Further research is needed to assess whether known strategies to improve endothelial function would bring potential benefits to Kawasaki disease patients.

Ultrasound protocols to measure carotid intima–media thickness: a post-hoc analysis of the OPAL study

2008 ◽  
Vol 25 (1) ◽  
pp. 109-122 ◽  
Author(s):  
S. Dogan ◽  
Y. Plantinga ◽  
G. W. Evans ◽  
R. Meijer ◽  
D. E. Grobbee ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Post Hoc Analysis ◽  
Media Thickness ◽  
Post Hoc

scholarly journals The Influence of Metabolic Syndrome Risk Factors on Carotid Intima Media Thickness in Children

2021 ◽  
Vol 8 ◽  
pp. 2333794X2098745
Author(s):  
Robert Downing ◽  
Timothy Michael ◽  
Rebecca Place ◽  
Eric Hoffman ◽  
Paul Visich
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Health Concern ◽  
Vascular Health ◽  
Major Health ◽  
Non Invasive ◽  
Media Thickness ◽  
Premature Cardiovascular Disease

Pediatric obesity is a major health concern today, which pre-disposes individuals to metabolic syndrome (MS), and the risk of premature cardiovascular disease (CVD). Use of carotid intima media thickness (CIMT) is recognized as non-invasive way to assess vascular health. The objective of this study was to determine which MBS risk factors has an influence on increasing one’s risk of an increased CIMT in children. In southern Maine 189 children (age: 10.52 ± .52 years) had their MBS risk factors and CIMT assessed. Based on CIMT, children were divided into quartiles and compared to MBS risk factors. Children in the highest quartile for CIMT had the highest waist circumference ( P < .05) compared to all other groups, using a one-way analysis of variance. No other MBS risk factors had an influence on CIMT. It appears early identification of children with an elevated WC may be beneficial in identifying children at risk of premature CVD.

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