Surface Engineering of Nanostructured Titanium Implants with Bioactive Ions

2016 ◽  
Vol 95 (5) ◽  
pp. 558-565 ◽  
Author(s):  
H.-S. Kim ◽  
Y.-J. Kim ◽  
J.-H. Jang ◽  
J.-W. Park
Keyword(s):  
Surface Engineering ◽  
Titanium Implants ◽  
Nanostructured Titanium

Surface Studies of Coarse-Grained and Nanostructured Titanium Implants

2012 ◽  
Vol 12 (11) ◽  
pp. 8567-8572 ◽  
Author(s):  
D. M. Korotin ◽  
S. Bartkowski ◽  
E. Z. Kurmaev ◽  
M. Neumann ◽  
E. B. Yakushina ◽  
...  
Keyword(s):  
Titanium Implants ◽  
Coarse Grained ◽  
Surface Studies ◽  
Nanostructured Titanium

Nano-Surface Modification on Titanium Implants for Drug Delivery

2007 ◽  
Vol 1054 ◽  
Author(s):  
Chang Yao ◽  
Thomas J Webster
Keyword(s):  
Drug Release ◽  
Surface Engineering ◽  
Physical Adsorption ◽  
Titanium Implants ◽  
Orthopedic Implant ◽  
Release Behavior ◽  
Oh Groups ◽  
Chemically Modified ◽  
Drug Release Behavior

ABSTRACTThe surface layer of titanium implants, i.e. titanium dioxide, is responsible for the inertness of titanium-based implants within the human body. However, their cytocompatibility properties and long-term efficacy are limited without further surface engineering since the average functional lifetime of an orthopedic implant is only 10 to 15 years. In this study, an electrochemical method known as anodization was used to create titania nanotubular structures on titanium implant surfaces. These nanotubes were about 60 nm wide (inner diameter) and 200 nm deep. In vitro studies found that anodized surfaces consisting of titania nanotube arrays were favored by bone-forming cells (osteoblasts) compared to unanodized surfaces. These titania nano-tubular structures were utilized here as novel drug release delivery systems. It is proposed that the system designed here can have multi-functional drug release to inhibit infection and wound inflammation while increasing new bone formation. For this purpose, antibiotic drugs (penicillin and streptomycin) were loaded into these nanotubular structures by physical adsorption. To mediate interactions between drug molecules and nanotube walls, anodized titanium nanotubes were modified by silanization to possess amine or methyl groups on their surface instead of −OH groups. Results showed increased hydrophobicity of chemically modified titania nanotubes (methyl > amine > hydroxyl terminated surface). These drug loaded substrates were soaked in phosphate buffered solution in a simulated body environment to determine drug release behavior. Buffer solutions were collected and replaced every day. The eluted drug amounts were measured spectroscopically. Results showed more antibiotic penicillin and streptomycin released from chemically modified nanotubes compared to unanodized titanium substrates; specifically, titania anodized nanotubes functionalized with −OH groups did quite well. In this manner, this study advances titanium currently used in orthopedics to possess drug release behavior which can improve orthopedic implant efficacy.

Bioactive Surface Engineering of Composite Titanium Implants

2021 ◽  
Vol 57 (9) ◽  
pp. 973-979
Author(s):  
T. S. Petrovskaya ◽  
N. E. Toropkov
Keyword(s):  
Surface Engineering ◽  
Titanium Implants

Surface engineering of titanium implants with enzyme-triggered antibacterial properties and enhanced osseointegrationin vivo

2018 ◽  
Vol 6 (48) ◽  
pp. 8090-8104 ◽  
Author(s):  
Zhang Yuan ◽  
Suzhou Huang ◽  
Shaoxiong Lan ◽  
Haizhou Xiong ◽  
Bailong Tao ◽  
...  
Keyword(s):  
Drug Release ◽  
Bacterial Adhesion ◽  
Surface Engineering ◽  
Antibacterial Properties ◽  
Titanium Implants ◽  
Antibacterial Drug ◽  
Effective Inhibition

A catechol-functionalized coating on a Van-loaded Ti implant achieves enhanced osseointegration and effective inhibition of bacterial adhesion and enzyme-triggered antibacterial drug release.

Adsorption of Alendronate onto Biomimetic Apatite Nanocrystals to Develop Drug Carrier Coating for Bone Implants

2012 ◽  
Vol 529-530 ◽  
pp. 475-479 ◽  
Author(s):  
Ruggero Bosco ◽  
Michele Iafisco ◽  
Jeroen van den Beucken ◽  
Sander C.G. Leeuwenburgh ◽  
John A. Jansen
Keyword(s):  
Drug Delivery ◽  
Surface Engineering ◽  
Drug Carrier ◽  
Local Treatment ◽  
Titanium Implants ◽  
Bone Implants ◽  
Bone Implant ◽  
Biomimetic Apatite

The possibility to develop a bone implant with bioactive aspects and in situ drug-delivery properties, in order to provide local treatment in vivo, is a big challenge. Where conventional surface modifications for bone implants focused on the deposition of ceramic (mostly calcium phosphate, CaP) coatings, current surface engineering approaches attempt to incorporate active features to render bone implant surfaces capable to direct biological performance. Biomimetic apatite nanocrystals (nAp) represent, among the CaPs, an elective material for bone applications and their surface functionalization with drugs allows them to act as a drug-delivery vehicle. Since load-bearing bone implants are increasingly used in patients with compromised health conditions, surface engineering is important to warrant the performance of these implants under such conditions. In view of this, bisphosphonates (BPs) represent a treatment modality for a variety of disorders of bone metabolism associated to bone loss, including Paget's bone disease, osteoporosis, fibrous dysplasia and bone metastases. In this work, we have synthesized and characterized bioinspired nAp and evaluated their functionalization with alendronate. In vitro tests will be used to evaluate the efficacy of the functionalized compound to impede the formation of osteoclasts and to show that alendronate-functionalized nAp can significantly reduce osteoclasteogenesis. Finally, alendronate-functionalized nAp (FnAp) has been deposited on titanium implants via the electrospray deposition technique in order to develop inorganic-organic coatings for bone implants with improved functionality.

scholarly journals Evaluating the osseointegration of nanostructured titanium implants in animal models: Current experimental methods and perspectives (Review)

2016 ◽  
Vol 11 (3) ◽  
pp. 030801 ◽  
Author(s):  
Vaclav Babuska ◽  
Omid Moztarzadeh ◽  
Tereza Kubikova ◽  
Amin Moztarzadeh ◽  
Daniel Hrusak ◽  
...  
Keyword(s):  
Animal Models ◽  
Experimental Methods ◽  
Titanium Implants ◽  
Nanostructured Titanium

Titanium Nanosurface Modification by Anodization for Orthopedic Applications

2004 ◽  
Vol 845 ◽  
Author(s):  
Chang Yao ◽  
Elliott B. Slamovich ◽  
Thomas J. Webster
Keyword(s):  
Titanium Surface ◽  
Cell Function ◽  
Bone Cells ◽  
Large Degree ◽  
Titanium Implants ◽  
Simple Method ◽  
Nanostructured Titanium ◽  
Anodized Titanium ◽  
Dental Applications

ABSTRACTTitanium is broadly used in orthopedic and dental applications mainly because of its optimal mechanical properties in load-bearing applications. However, insufficient new bone formation is frequently observed on titanium which sometimes leads to implant loosening and failure. For this reason, the objective of the present in vitro study was to modify the surface of conventional titanium to include nanostructured surface features that promote the functions of osteoblasts (bone-forming cells). This study focused on creating nanostructured titanium surfaces since bone itself has a large degree of nanostructured roughness that bone cells are accustomed to interacting with. In this study, the surface of titanium was modified by anodic oxidation techniques. The electrolyte used for anodization was hydrofluoric acid. Depending on acid concentration and anodization time, two kinds of different nano-architectures, either particulate or tube-like structures, were formed on the titanium surface. X-ray diffraction results confirmed that the titanium oxide formed on the surface of titanium was amorphous. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to characterize the surface morphology. Cell adhesion studies showed that the anodized nanostructured titanium surface promoted osteoblast adhesion compared to non-anodized titanium. This result indicated that anodization may be a simple method to modify the surface of titanium implants to enhance bone-forming cell function thereby increasing orthopedic implant efficacy.

Surface functionalization via PEO coating and RGD peptide for nanostructured titanium implants and their in vitro assessment

2019 ◽  
Vol 357 ◽  
pp. 669-683 ◽  
Author(s):  
Evgeny V. Parfenov ◽  
Lyudmila V. Parfenova ◽  
Grigory S. Dyakonov ◽  
Ksenia V. Danilko ◽  
Veta R. Mukaeva ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Rgd Peptide ◽  
Titanium Implants ◽  
Nanostructured Titanium ◽  
In Vitro Assessment
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