Surface Studies of Coarse-Grained and Nanostructured Titanium Implants

2012 ◽  
Vol 12 (11) ◽  
pp. 8567-8572 ◽  
Author(s):  
D. M. Korotin ◽  
S. Bartkowski ◽  
E. Z. Kurmaev ◽  
M. Neumann ◽  
E. B. Yakushina ◽  
...  
Keyword(s):  
Titanium Implants ◽  
Coarse Grained ◽  
Surface Studies ◽  
Nanostructured Titanium

scholarly journals Superficial Characteristics of Titanium after Treatment of Chorreated Surface, Passive Acid, and Decontamination with Argon Plasma

2018 ◽  
Vol 9 (4) ◽  
pp. 71 ◽  
Author(s):  
María Rizo-Gorrita ◽  
Irene Luna-Oliva ◽  
María-Angeles Serrera-Figallo ◽  
Daniel Torres-Lagares
Keyword(s):  
Dental Implants ◽  
Photoelectron Spectroscopy ◽  
Bone Growth ◽  
Relative Concentration ◽  
Argon Plasma ◽  
Titanium Implants ◽  
Total Carbon ◽  
Coarse Grained ◽  
Topographic Analysis ◽  
Total Carbon Content

(1) Background. Titanium is characterized by its biocompatibility, resistance to maximum stress, and fatigue and non-toxicity. The composition, surface structure, and roughness of titanium have a key and direct influence on the osseointegration processes when it is used in the form of dental implants. The objective of the present study is to characterize, at chemical, superficial, and biological levels, the result of the application of the sandblasted with large-grit and acid-etched (SLA) treatment consisting of coarse-grained and double-passivated acid blasting with subsequent decontamination with argon plasma on the surface of titanium implants type IV. (2) Methods. Four Oxtein® dental implants (Zaragoza, Spain) were investigated with the following coding: Code L63713T (titanium grade IV, 3.75 mm in diameter, and 13 mm in length). The surface of the implants was SLA type obtained from coarse-grained, double passivated acid, and decontaminated with argon plasma. The samples were in their sealed packages and were opened in our laboratory. The X-ray photoelectron spectroscopy (XPS) technique was used to characterize the chemical composition of the surface, and the scanning electronic microscope (SEM) technique was used to perform topographic surface evaluation. Cell cultures were also performed on both surfaces. (3) Results. The superficial chemical analysis of the studied samples presented the following components, approximately, expressed in atomic percentage: O: 39%; Ti: 18%; C: 39%; N: 2%; and Si: 1%. In the same way, the topographic analysis values were obtained in the evaluated roughness parameters: Ra: 1.5 μm ± 0.02%; Rq: 1.31 μm ± 0.33; Rz: 8.98 μm ± 0.73; Rp: 5.12 μm ± 0.48; Rv: 3.76 μm ± 0.51; and Rc: 4.92 μm ± 0.24. At a biological level, the expression of osteocalcin was higher (p < 0.05) on the micro-rough surface compared to that machined at 48 and 96 h of culture. (4) Conclusions. The data obtained in our study indicate that the total carbon content, the relative concentration of titanium, and the roughness of the treatment performed on the implants are in agreement with those found in the literature. Further, the roughness of the treatment performed on the implants throws a spongy, three-dimensional surface suitable for bone growth on it. The biological results found are compatible with the clinical use of the surface tested.

scholarly journals Evaluating the osseointegration of nanostructured titanium implants in animal models: Current experimental methods and perspectives (Review)

2016 ◽  
Vol 11 (3) ◽  
pp. 030801 ◽  
Author(s):  
Vaclav Babuska ◽  
Omid Moztarzadeh ◽  
Tereza Kubikova ◽  
Amin Moztarzadeh ◽  
Daniel Hrusak ◽  
...  
Keyword(s):  
Animal Models ◽  
Experimental Methods ◽  
Titanium Implants ◽  
Nanostructured Titanium

Surface Engineering of Nanostructured Titanium Implants with Bioactive Ions

2016 ◽  
Vol 95 (5) ◽  
pp. 558-565 ◽  
Author(s):  
H.-S. Kim ◽  
Y.-J. Kim ◽  
J.-H. Jang ◽  
J.-W. Park
Keyword(s):  
Surface Engineering ◽  
Titanium Implants ◽  
Nanostructured Titanium

Titanium Nanosurface Modification by Anodization for Orthopedic Applications

2004 ◽  
Vol 845 ◽  
Author(s):  
Chang Yao ◽  
Elliott B. Slamovich ◽  
Thomas J. Webster
Keyword(s):  
Titanium Surface ◽  
Cell Function ◽  
Bone Cells ◽  
Large Degree ◽  
Titanium Implants ◽  
Simple Method ◽  
Nanostructured Titanium ◽  
Anodized Titanium ◽  
Dental Applications

ABSTRACTTitanium is broadly used in orthopedic and dental applications mainly because of its optimal mechanical properties in load-bearing applications. However, insufficient new bone formation is frequently observed on titanium which sometimes leads to implant loosening and failure. For this reason, the objective of the present in vitro study was to modify the surface of conventional titanium to include nanostructured surface features that promote the functions of osteoblasts (bone-forming cells). This study focused on creating nanostructured titanium surfaces since bone itself has a large degree of nanostructured roughness that bone cells are accustomed to interacting with. In this study, the surface of titanium was modified by anodic oxidation techniques. The electrolyte used for anodization was hydrofluoric acid. Depending on acid concentration and anodization time, two kinds of different nano-architectures, either particulate or tube-like structures, were formed on the titanium surface. X-ray diffraction results confirmed that the titanium oxide formed on the surface of titanium was amorphous. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to characterize the surface morphology. Cell adhesion studies showed that the anodized nanostructured titanium surface promoted osteoblast adhesion compared to non-anodized titanium. This result indicated that anodization may be a simple method to modify the surface of titanium implants to enhance bone-forming cell function thereby increasing orthopedic implant efficacy.

Synthesis and Properties of Hydroxyapatite-Containing Porous Titania Coating on Titanium by Ultrasonic Shot Peening and Micro-Arc Oxidation

2013 ◽  
Vol 690-693 ◽  
pp. 2081-2084 ◽  
Author(s):  
Zhen Nan Deng ◽  
Jin Song Liu ◽  
Yun He ◽  
Si Qian Wang ◽  
Jian Feng Ma
Keyword(s):  
Shot Peening ◽  
Biological Properties ◽  
Titanium Implants ◽  
Coarse Grained ◽  
Phase Identification ◽  
Porous Titania ◽  
Surface Nanostructure ◽  
Ultrasonic Shot Peening ◽  
Micro Arc Oxidation ◽  
Titania Coatings

Titanium with surface nanostructure has superior mechanical and biological properties, which benefits titanium implants. To further improve the bioactivity of Ti surfaces, Ca/P-containing porous titania coatings were prepared on Ti with surface nanostructure by ultrasonic shot peening (USP) and micro-arc oxidation (MAO). The phase identification, composition, morphology and microstructure of the coatings of Ti with surface nanostructure during MAO were investigated subsequently. The amounts of Ca, P and the Ca/P ratio of the coatings formed on Ti with surface nanostructure were greater than those on coarse-grained Ti. Incubated in a simulated body fluid, bone-like apatite was completely formed on the surface of Ti, thus evidencing preferable bioactivity.

Surface functionalization via PEO coating and RGD peptide for nanostructured titanium implants and their in vitro assessment

2019 ◽  
Vol 357 ◽  
pp. 669-683 ◽  
Author(s):  
Evgeny V. Parfenov ◽  
Lyudmila V. Parfenova ◽  
Grigory S. Dyakonov ◽  
Ksenia V. Danilko ◽  
Veta R. Mukaeva ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Rgd Peptide ◽  
Titanium Implants ◽  
Nanostructured Titanium ◽  
In Vitro Assessment

scholarly journals The Fate of Osteoblast-Like MG-63 Cells on Pre-Infected Bactericidal Nanostructured Titanium Surfaces

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1575 ◽  
Author(s):  
Jason V. Wandiyanto ◽  
Vi Khanh Truong ◽  
Mohammad Al Kobaisi ◽  
Saulius Juodkazis ◽  
Helmut Thissen ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Titanium Implants ◽  
The Body ◽  
Eukaryotic Cells ◽  
Resistant Bacteria ◽  
Bacterial Cells ◽  
Load Bearing ◽  
Nanostructured Titanium ◽  
Nanostructured Surfaces ◽  
Titanium Surfaces

Biomaterials that have been newly implanted inside the body are the substratum targets for a “race for the surface”, in which bacterial cells compete against eukaryotic cells for the opportunity to colonize the surface. A victory by the former often results in biomaterial-associated infections, which can be a serious threat to patient health and can undermine the function and performance of the implant. Moreover, bacteria can often have a ‘head start’ if implant contamination has taken place either prior to or during the surgery. Current prevention and treatment strategies often rely on systemic antibiotic therapies, which are becoming increasingly ineffective due to a growing prevalence of antibiotic-resistant bacteria. Nanostructured surfaces that kill bacteria by physically rupturing bacterial cells upon contact have recently emerged as a promising solution for the mitigation of bacterial colonization of implants. Furthermore, these nanoscale features have been shown to enhance the adhesion and proliferation of eukaryotic cells, which is a key to, for example, the successful osseointegration of load-bearing titanium implants. The bactericidal activity and biocompatibility of such nanostructured surfaces are often, however, examined separately, and it is not clear to what extent bacterial cell-surface interactions would affect the subsequent outcomes of host-cell attachment and osseointegration processes. In this study, we investigated the ability of bactericidal nanostructured titanium surfaces to support the attachment and growth of osteoblast-like MG-63 human osteosarcoma cells, despite them having been pre-infected with pathogenic bacteria. MG-63 is a commonly used osteoblastic model to study bone cell viability, adhesion, and proliferation on the surfaces of load-bearing biomaterials, such as titanium. The nanostructured titanium surfaces used here were observed to kill the pathogenic bacteria, whilst simultaneously enhancing the growth of MG-63 cells in vitro when compared to that occurring on sterile, flat titanium surfaces. These results provide further evidence in support of nanostructured bactericidal surfaces being used as a strategy to help eukaryotic cells win the “race for the surface” against bacterial cells on implant materials.

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