Stress-Response Syndromes: A Review of Posttraumatic and Adjustment Disorders

1986 ◽  
Vol 37 (3) ◽  
pp. 241-249 ◽  
Author(s):  
Mardi J. Horowitz
2007 ◽  
Vol 40 (3) ◽  
pp. 135-146 ◽  
Author(s):  
Andreas Maercker ◽  
Franziska Einsle ◽  
Volker Köllner

Author(s):  
Anne Doherty

The biological basis of adjustment disorders examines the evidence for the biological factors associated with this common diagnosis. Although adjustment disorder is usually characterized as a disorder of psychological adjustment to life stressors, and while it shares overlapping psychopathology with both normal stress response and with major depression, there is evidence that the diagnosis may have pathophysiological characteristics that distinguish it from both. This chapter explores the evidence supporting underlying theories derived from diverse fields including genetics, neuroimaging, and neuroendocrine and neurotransmitter functioning, and considers how the pharmacological management of adjustment disorder is linked to said theories. It discusses the gaps in our knowledge and considers the causes for the relative lack of interest in this diagnosis compared with other diagnoses.


2020 ◽  
Vol 86 (1) ◽  
pp. 39-45
Author(s):  
H. Kozhyna ◽  
O.V. Druz ◽  
K. Zelenska ◽  
I. Chernenko

The clinical phenomenology of post-stress disorders was studied in combatants. We observed 150 servicemen of the Armed Forces of Ukraine, who took a direct part in the fighting in the ATO zone, in accordance with the principles of bioethics and deontology on the basis of the National Military Medical Clinical Center «Main Military Clinical Hospital» and the Military Medical Center of the Northern Region. It is shown, that the clinical structure of post-stress disorders in combatants is represented by posttraumatic stress disorder (PTSD), acute stress response and adjustment disorders. The clinical structure of PTSD in combatants is represented by anxious (35.2 % of men and 44.2 % of women), dysphoric (33.5 % and 9.4 %), asthenic (25.4 % and 32.6 %) and somatoform (5.9 % and 13.8 %) syndrome complexes. Adjustment disorders included prolonged depressive reaction (10.1 % of men and 15.7 % of women), mixed anxiety-depressive reaction (16.5 % and 10.2 %), adjustment disorders with a predominance of disturbances of other emotions (9.8 % and 7.4 %). The major risk factors for the development of stress-related disorders in combatants were identified: prolonged participation in combat, the need to see and touch the bodies of the dead, the threat of death from sniper’s fire, the death of friends in their own eyes, the impact of harmful combat factors, family conflicts, adverse social and economic circumstances. The correlation analysis was carried out. It was found, that the severity of psychopathological symptoms is determined by the severity of combat mental trauma. High scores on the Mississippi scale are associated with prolonged mental trauma (rxy=0.64), threat of death (rxy=0.58), death of comrades (rxy=0.54), participation in close combat (rxy=0.50), the offensive (rxy=0.41), the need to touch the bodies of the dead (rxy=0.46), with the killing of opponents (rxy=0.45). There is a strong correlation of combat mental trauma with anxiety intensity (rxy=0.78), fear (rxy=0.71), sense of internal tension (rxy=0.70), disturbance of the sleep-wake cycle (rxy=0.70), incontinence of affect (rxy=0.69) and depression (rxy=0.66). Keywords: post-traumatic stress disorder, adjustment disorders, acute stress response, combat mental trauma, correlation analysis.


2011 ◽  
Vol 28 (9) ◽  
pp. 818-823 ◽  
Author(s):  
James J. Strain ◽  
Matthew J. Friedman

2019 ◽  
Vol 476 (21) ◽  
pp. 3141-3159 ◽  
Author(s):  
Meiru Si ◽  
Can Chen ◽  
Zengfan Wei ◽  
Zhijin Gong ◽  
GuiZhi Li ◽  
...  

Abstract MarR (multiple antibiotic resistance regulator) proteins are a family of transcriptional regulators that is prevalent in Corynebacterium glutamicum. Understanding the physiological and biochemical function of MarR homologs in C. glutamicum has focused on cysteine oxidation-based redox-sensing and substrate metabolism-involving regulators. In this study, we characterized the stress-related ligand-binding functions of the C. glutamicum MarR-type regulator CarR (C. glutamicum antibiotic-responding regulator). We demonstrate that CarR negatively regulates the expression of the carR (ncgl2886)–uspA (ncgl2887) operon and the adjacent, oppositely oriented gene ncgl2885, encoding the hypothetical deacylase DecE. We also show that CarR directly activates transcription of the ncgl2882–ncgl2884 operon, encoding the peptidoglycan synthesis operon (PSO) located upstream of carR in the opposite orientation. The addition of stress-associated ligands such as penicillin and streptomycin induced carR, uspA, decE, and PSO expression in vivo, as well as attenuated binding of CarR to operator DNA in vitro. Importantly, stress response-induced up-regulation of carR, uspA, and PSO gene expression correlated with cell resistance to β-lactam antibiotics and aromatic compounds. Six highly conserved residues in CarR were found to strongly influence its ligand binding and transcriptional regulatory properties. Collectively, the results indicate that the ligand binding of CarR induces its dissociation from the carR–uspA promoter to derepress carR and uspA transcription. Ligand-free CarR also activates PSO expression, which in turn contributes to C. glutamicum stress resistance. The outcomes indicate that the stress response mechanism of CarR in C. glutamicum occurs via ligand-induced conformational changes to the protein, not via cysteine oxidation-based thiol modifications.


Crisis ◽  
2001 ◽  
Vol 22 (3) ◽  
pp. 125-131 ◽  
Author(s):  
Ludmila Kryzhanovskaya ◽  
Randolph Canterbury

Summary: This retrospective study characterizes the suicidal behavior in 119 patients with Axis I adjustment disorders as assessed by psychiatrists at the University of Virginia Hospital. Results indicated that 72 patients (60.5%) had documented suicide attempts in the past, 96% had been suicidal during their admission to the hospital, and 50% had attempted suicide before their hospitalization. The most commonly used method of suicide attempts was overdosing. Of the sample group with suicide attempts in the past, 67% had Axis II diagnoses of borderline personality disorder and antisocial personality disorder. Adjustment disorder diagnosis in patients with the suicide attempts was associated with a high level of suicidality at admission, involuntary hospitalization and substance-abuse disorders. Axis II diagnoses in patients with adjustment disorders constituted risk factors for further suicidal behavior. Additional future prospective studies with reliability checks on diagnosis of adjustment disorders and suicidal behavior are needed.


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