Bipolar disorder in idiopathic dystonia: clinical features and possible neurobiology

1992 ◽  
Vol 4 (4) ◽  
pp. 435-439 ◽  
2015 ◽  
Vol 17 (8) ◽  
pp. 892-901 ◽  
Author(s):  
Pierpaolo Medda ◽  
Cristina Toni ◽  
Federica Luchini ◽  
Michela Giorgi Mariani ◽  
Mauro Mauri ◽  
...  

2018 ◽  
Vol 225 ◽  
pp. 201-206 ◽  
Author(s):  
Sarah Tebeka ◽  
Yann Le Strat ◽  
Caroline Dubertret

2020 ◽  
Vol 42 (4) ◽  
pp. 373-381
Author(s):  
Hanife Kocakaya ◽  
Emrah Songur ◽  
Sedat Batmaz ◽  
Zekiye Çelikbaş ◽  
Önder Küçük

2010 ◽  
Vol 71 (03) ◽  
pp. 296-303 ◽  
Author(s):  
Roy H. Perlis ◽  
Michael J. Ostacher ◽  
David J. Miklowitz ◽  
Aleena Hay ◽  
Andrew A. Nierenberg ◽  
...  

2017 ◽  
Vol 76 ◽  
pp. 169-176 ◽  
Author(s):  
Bernardo Dell’Osso ◽  
Giulia Camuri ◽  
Laura Cremaschi ◽  
Cristina Dobrea ◽  
Massimiliano Buoli ◽  
...  

Author(s):  
Michele Fornaro ◽  
Domenico De Berardis ◽  
Ann Koshy ◽  
Giampaolo Perna ◽  
Davy Vancampfort ◽  
...  

2019 ◽  
Vol 50 (14) ◽  
pp. 2346-2354 ◽  
Author(s):  
Steven Marwaha ◽  
Paul M. Briley ◽  
Amy Perry ◽  
Phillip Rankin ◽  
Arianna DiFlorio ◽  
...  

AbstractBackgroundChildhood abuse is a risk factor for poorer illness course in bipolar disorder, but the reasons why are unclear. Trait-like features such as affective instability and impulsivity could be part of the explanation. We aimed to examine whether childhood abuse was associated with clinical features of bipolar disorder, and whether associations were mediated by affective instability or impulsivity.MethodsWe analysed data from 923 people with bipolar I disorder recruited by the Bipolar Disorder Research Network. Adjusted associations between childhood abuse, affective instability and impulsivity and eight clinical variables were analysed. A path analysis examined the direct and indirect links between childhood abuse and clinical features with affective instability and impulsivity as mediators.ResultsAffective instability significantly mediated the association between childhood abuse and earlier age of onset [effect estimate (θ)/standard error (SE): 2.49], number of depressive (θ/SE: 2.08) and manic episodes/illness year (θ/SE: 1.32), anxiety disorders (θ/SE: 1.98) and rapid cycling (θ/SE: 2.25). Impulsivity significantly mediated the association between childhood abuse and manic episodes/illness year (θ/SE: 1.79), anxiety disorders (θ/SE: 1.59), rapid cycling (θ/SE: 1.809), suicidal behaviour (θ/SE: 2.12) and substance misuse (θ/SE: 3.09). Measures of path analysis fit indicated an excellent fit to the data.ConclusionsAffective instability and impulsivity are likely part of the mechanism of why childhood abuse increases risk of poorer clinical course in bipolar disorder, with each showing some selectivity in pathways. They are potential novel targets for intervention to improve outcome in bipolar disorder.


2019 ◽  
Vol 215 (01) ◽  
pp. 383-385 ◽  
Author(s):  
Isabel Valli ◽  
Chiara Fabbri ◽  
Allan H. Young

SummarySchizophrenia and bipolar disorder are genetically related and their clinical features overlap. Schizophrenia is conceptualised as a neurodevelopmental disorder but the evidence for bipolar disorder is less clear. Cluster-analytic approaches reveal different cognitive profiles within bipolar disorder, possibly reflective of differing neurodevelopmental loads, which are also suggested by recent genetic and neuroimaging studies. Such studies suggest the potential utility of further clinical subcategories in bipolar disorder based on neurodevelopmental load.Declaration of interestNone.


2014 ◽  
Vol 168 ◽  
pp. 58-63 ◽  
Author(s):  
Xian-Bin Li ◽  
Jin-Tong Liu ◽  
Xiong-Zhao Zhu ◽  
Liang Zhang ◽  
Yi-Lang Tang ◽  
...  

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