Lifetime presence of psychotic symptoms in bipolar disorder is associated with less favorable socio-demographic and certain clinical features

2017 ◽  
Vol 76 ◽  
pp. 169-176 ◽  
Author(s):  
Bernardo Dell’Osso ◽  
Giulia Camuri ◽  
Laura Cremaschi ◽  
Cristina Dobrea ◽  
Massimiliano Buoli ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Clinical Features ◽  
Psychotic Symptoms

Psychotic versus non-psychotic bipolar disorder: Socio-demographic and clinical profiles in an Italian nationwide study

2019 ◽  
Vol 53 (8) ◽  
pp. 772-781 ◽  
Author(s):  
Alfredo Carlo Altamura ◽  
Massimiliano Buoli ◽  
Bruno Mario Cesana ◽  
Andrea Fagiolini ◽  
Andrea de Bartolomeis ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Confidence Interval ◽  
Clinical Features ◽  
Odds Ratio ◽  
Age At Onset ◽  
Psychotic Symptoms ◽  
Bipolar Type ◽  
Bipolar Patients ◽  
Depressive Episodes ◽  
First Diagnosis

Objective: Psychotic versus non-psychotic patients with bipolar disorder have been traditionally associated with different unfavorable clinical features. In this study on bipolar Italian patients, we aimed to compare clinical and demographic differences between psychotic and non-psychotic individuals, exploring clinical factors that may favor early diagnosis and personalized treatment. Methods: A total of 1671 patients (males: n = 712 and females: n = 959; bipolar type 1: n = 1038 and bipolar type 2: n = 633) from different psychiatric departments were compared according to the lifetime presence of psychotic symptoms in terms of socio-demographic and clinical variables. Chi-square tests for qualitative variables and Student’s t-tests for quantitative variables were performed for group comparison, and a multivariable logistic regression was performed, considering the lifetime psychotic symptoms as dependent variables and socio-demographic/clinical characteristics as independent variables. Results: Psychotic versus non-psychotic bipolar subjects resulted to: be more frequently unemployed ( p < 0.01) and never married/partnered ( p < 0.01); have an earlier age at onset ( p < 0.01); more frequently receive a first diagnosis different from a mood disorder ( p < 0.01); have a shorter duration of untreated illness ( p < 0.01); have a more frequently hypomanic/manic prevalent polarity ( p < 0.01) and a prevalent manic–depressive type of cycling ( p < 0.01); present a lower lifetime number of depressive episodes ( p < 0.01), but have more manic episodes ( p < 0.01); and less insight ( p < 0.01) and more hospitalizations in the last year ( p < 0.01). Multivariable regression analysis showed that psychotic versus non-psychotic bipolar patients received more frequently a first diagnosis different from bipolar disorder (odds ratio = 0.64, 95% confidence interval = [0.46, 0.90], p = 0.02) or major depressive disorder (odds ratio = 0.66, 95% confidence interval = [0.48, 0.91], p = 0.02), had more frequently a prevalent manic polarity (odds ratio = 1.84, 95% confidence interval = [1.14, 2.98], p < 0.01) and had a higher number of lifetime manic episodes (more than six) (odds ratio = 8.79, 95% confidence interval = [5.93, 13.05], p < 0.01). Conclusion: Lifetime psychotic symptoms in bipolar disorder are associated with unfavorable socio-demographic and clinical features as well as with a more frequent initial misdiagnosis.

Catatonia in 26 patients with bipolar disorder: clinical features and response to electroconvulsive therapy

2015 ◽  
Vol 17 (8) ◽  
pp. 892-901 ◽  
Author(s):  
Pierpaolo Medda ◽  
Cristina Toni ◽  
Federica Luchini ◽  
Michela Giorgi Mariani ◽  
Mauro Mauri ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Clinical Features ◽  
Electroconvulsive Therapy

scholarly journals Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder

2011 ◽  
Vol 156 (3) ◽  
pp. 370-378 ◽  
Author(s):  
Pamela Belmonte Mahon ◽  
Mehdi Pirooznia ◽  
Fernando S. Goes ◽  
Fayaz Seifuddin ◽  
Jo Steele ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Analysis ◽  
Age At Onset ◽  
Genome Wide Association ◽  
Psychotic Symptoms ◽  
Genome Wide Association Analysis ◽  
Genome Wide

Cocaine Dependence Produce Psychiatric Symptoms - a Case Report

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M. Stankovic ◽  
S. Vucetic-Arsic ◽  
S. Alcaz ◽  
J. Cvejic
Keyword(s):  
Clinical Features ◽  
Male Patient ◽  
Psychiatric Symptoms ◽  
Cocaine Dependence ◽  
Psychotic Symptoms ◽  
Personal Contact ◽  
Outpatient Unit ◽  
Special Hospital ◽  
First Time ◽  
The Brain

Aim:We want to present a polymorphic clinical features like: hallutinations, paranoid ideas, agitation and violence as a result of prolonged cocaine intranasal consumption.Methods:We exposed a 30-year old male patient with ICD-X diagnostic criteria for cocaine dependence (intranasal consumption) that treated in the outpatient unit of Special Hospital of Addicitons, Belgrade, Serbia from April to July 2008. We used the medical records, psychical examination, psychiatric interwievs, standard blood sampling and cocaine urine detections sample (positive).Results:Observations a specific and polymorphic clinical features with presence of psychotic symptoms after cocaine consumptions in our male patient, for the first time after 5 years of cocaine dependence: auditory hallucinations (two- voice speakers), paranoid persecution ideas and suspiciousness, agitation with appearance of vegetative symptomatology (palpitations, sweating, pupil dilatation), extremely violence behavior to other people, complete social reductions (“armed to the outside world”, refused any personal contact and isolated from friends and family, permanent outdoor checking). There was an intensive fear too and impaired judgment.Conclusions:Permanent cocaine consumption can result with produce a numerous of psychiatric symptoms and syndromes as our experience does. It is similar to the findings of other studies and papers reviewed. It is suppose that cocaine has numerous effects on important neurotransmitters in the brain, such as increase as well as the release of dopamine and it related with aggressiveness, hallucinations and other psychiatric symptoms.

Baseline and prodromal characteristics of first- versus multiple-episode mania in a French cohort of bipolar patients

2011 ◽  
Vol 27 (8) ◽  
pp. 557-562 ◽  
Author(s):  
J.-M. Azorin ◽  
A. Kaladjian ◽  
M. Adida ◽  
E. Fakra ◽  
E. Hantouche ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicide Attempts ◽  
Correct Diagnosis ◽  
Manic Episode ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Prodromal Phase ◽  
Multiple Episode ◽  
Patients At Risk ◽  
Bipolar Patients

AbstractObjective:To identify some of the main features of bipolar disorder for both first-episode (FE) mania and the preceding prodromal phase, in order to increase earlier recognition.Methods:One thousand and ninety manic patients (FE=81, multiple-episodes [ME]=1009) were assessed for clinical and temperamental characteristics.Results:Compared to ME, FE patients reported more psychotic and less depressive symptoms but were comparable with respect to temperamental measures and comorbid anxiety. The following independent variables were associated with FE mania: a shorter delay before correct diagnosis, greater substance use, being not divorced, greater stressors before current mania, a prior diagnosis of an anxiety disorder, lower levels of depression during index manic episode, and more suicide attempts in the past year.Conclusion:In FE patients, the diagnosis of mania may be overlooked, as they present with more psychotic symptoms than ME patients. The prodromal phase is characterised by high levels of stress, suicide attempts, anxiety disorders and alcohol or substance abuse. Data suggest to consider these prodromes as harmful consequences of temperamental predispositions to bipolar disorder that may concur to precipitate mania onset. Their occurrence should therefore incite clinicians to screen for the presence of such predispositions, in order to identify patients at risk of FE mania.

Is parity status associated with bipolar disorder clinical features, severity or evolution?

2018 ◽  
Vol 225 ◽  
pp. 201-206 ◽  
Author(s):  
Sarah Tebeka ◽  
Yann Le Strat ◽  
Caroline Dubertret
Keyword(s):  
Bipolar Disorder ◽  
Clinical Features

scholarly journals Impact of metabolic syndrome and clinical features on functioning in patients with bipolar disorder: a cross-sectional study

2020 ◽  
Vol 42 (4) ◽  
pp. 373-381
Author(s):  
Hanife Kocakaya ◽  
Emrah Songur ◽  
Sedat Batmaz ◽  
Zekiye Çelikbaş ◽  
Önder Küçük
Keyword(s):  
Metabolic Syndrome ◽  
Bipolar Disorder ◽  
Clinical Features ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Psychotic symptoms in bipolar disorder: Two years’ retrospective study

2017 ◽  
Vol 13 (1) ◽  
pp. 49-57
Author(s):  
Baikuntha Raj Adhikari ◽  
S Mishra ◽  
S Nepal ◽  
N Sapkota
Keyword(s):  
Bipolar Disorder ◽  
Retrospective Study ◽  
Bipolar Depression ◽  
Bipolar Disorders ◽  
Unipolar Depression ◽  
Common Type ◽  
Psychotic Symptoms ◽  
Mixed Episode ◽  
Auditory Verbal Hallucinations ◽  
Primary Substance

Background: Psychosis in bipolar disorder is common but still not well understood. There is paucity of literature from our country and none from this institute which serves the eastern part of Nepal.Objective: To describe the hallucinations and delusions in bipolar disorders in our place.Methods: Patients-record files of bipolar disorders with psychosis discharged in two years’ time from 2012 to 2014 were analysed. Patients with unipolar depression, recurrent depressive disorder, serious organic illness, and primary substance use disorders were excluded. Information was collected in a structured performa. Association of delusion and hallucination was observed.Results: During the study period, ninety-five patients with bipolardisorder had psychosis. Hallucination was present in 29 (30.5%) cases, and out of these 23 (79.3%) were cases of mania. In 26 (89.7%) patients, the hallucinations were mood congruent. The median duration of appearance of hallucination was 10 days and appeared early in mania. Among hallucinations, auditory verbal hallucinations were present in all 29 patients. Delusions were present in 77 (81.1%) of patients, and grandiose delusions were the most common. Grandiose delusions tended to occur even in the absence of hallucinations. Conclusion: Psychosis is common in bipolar disorder. Grandiose delusions are the most common delusion and are relatively independent of hallucination. The auditory verbal hallucinations are the most common type of hallucination. Hallucinations in mania tend to manifest earlier than in bipolar depression and mixed episode, and most of the hallucinations in bipolar disorder are mood congruent. Health Renaissance 2015;13 (1): 49-57

Irritable temperament and lifetime psychotic symptoms as predictors of anxiety symptoms in bipolar disorder

2017 ◽  
Vol 72 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Gianluca Serafini ◽  
Pierre A. Geoffroy ◽  
Andrea Aguglia ◽  
Giulia Adavastro ◽  
Giovanna Canepa ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anxiety Symptoms ◽  
Psychotic Symptoms
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