scholarly journals Altered regulation of apolipoprotein A-IV gene expression in the liver of the genetically obese Zucker rat.

1993 ◽  
Vol 92 (4) ◽  
pp. 1766-1773 ◽  
Author(s):  
W Strobl ◽  
B Knerer ◽  
R Gratzl ◽  
K Arbeiter ◽  
Y C Lin-Lee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Zucker Rat ◽  
Apolipoprotein A ◽  
Obese Zucker Rat ◽  
Altered Regulation

scholarly journals Adipsin mRNA amounts are not decreased in the genetically obese Zucker rat

1989 ◽  
Vol 257 (3) ◽  
pp. 917-919 ◽  
Author(s):  
I Dugail ◽  
X Le Liepvre ◽  
A Quignard-Boulangé ◽  
J Pairault ◽  
M Lavau
Keyword(s):  
Gene Expression ◽  
High Fat Diet ◽  
Zucker Rats ◽  
Zucker Rat ◽  
Obese Mice ◽  
High Fat ◽  
Adult Rats ◽  
Obese Zucker Rat ◽  
Obese Rats ◽  
Obese Zucker Rats

Adipsin gene expression as assessed by mRNA amounts was examined in adipose tissue of genetically obese rats at the onset (16 days of age) or at later stages (30 and 60 days of age) of obesity. Amounts of mRNA were equivalent in obese and lean rats at 16 days of age. In adult rats, we observed a 2-fold decrease in adipsin mRNA in the obese rats compared with control lean rats, which was abolished by weaning the animals on a high-fat diet. Our data show that, in sharp contrast with genetically obese mice, adipsin mRNA is not suppressed in genetically obese Zucker rats.

scholarly journals Correction: A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model

2019 ◽  
Vol 10 (12) ◽  
pp. 8309-8309
Author(s):  
Eric Rochester ◽  
Brooke E. Wickman ◽  
Andrea Bell ◽  
Christy Simecka ◽  
Zachary S. Clayton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Density ◽  
Rat Model ◽  
Zucker Rat ◽  
Obese Zucker Rat ◽  
Osteogenic Gene Expression ◽  
Osteogenic Gene

Correction for ‘A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model’ by Eric Rochester et al., Food Funct., 2019, 10, 6851–6857.

scholarly journals A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model

2019 ◽  
Vol 10 (10) ◽  
pp. 6851-6857 ◽  
Author(s):  
Eric Rochester ◽  
Brooke E. Wickman ◽  
Andrea Bell ◽  
Christy Simecka ◽  
Zachary S. Clayton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Density ◽  
Rat Model ◽  
Zucker Rat ◽  
Chemical Structures ◽  
Similar Chemical ◽  
Obese Zucker Rat ◽  
Osteogenic Gene Expression ◽  
Osteogenic Gene ◽  
Plant Compounds

Phytoestrogens are nonsteroidal plant compounds with similar chemical structures to mammalian estrogen capable of mimicking the effect of estrogen in selective tissues.

scholarly journals Insulin resistance is accompanied by impairment of amylase-gene expression in the exocrine pancreas of the obese Zucker rat

1986 ◽  
Vol 237 (3) ◽  
pp. 807-812 ◽  
Author(s):  
E R Trimble ◽  
R Bruzzone ◽  
D Belin
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Pancreatic Amylase ◽  
Zucker Rat ◽  
Amylase Gene ◽  
Plasma Insulin Concentration ◽  
Pancreatic Acini ◽  
Obese Zucker Rat ◽  
Obese Rats

Insulin plays a major role in the control of pancreatic amylase biosynthesis. In this study we determined glucose metabolism by pancreatic acini as well as the pancreatic content of both amylase protein and amylase mRNA during development of insulin resistance in the obese Zucker rat. At age 4 weeks there were no abnormalities detected in the above parameters, although the obese animals were already hyperinsulinaemic. At 6 weeks glucose metabolism was decreased by 50% in acini from obese rats, whereas pancreatic amylase-gene expression was only slightly impaired. At 22 weeks glucose metabolism was decreased by 50%, amylase content by 55% and amylase mRNA by 60% in acinar tissue of obese rats. As expected, hyperinsulinaemia increased markedly with age. Thus development of severe insulin resistance was associated with impairment of amylase-gene expression. To decrease insulin resistance, one group of adult obese rats was treated with Ciglitazone for 4 weeks. A lowered plasma insulin concentration without alteration of food intake was taken as evidence of decreased insulin resistance. This was associated with normalization of glucose metabolism and a marked increase of both amylase content of pancreatic tissue and amylase mRNA. In conclusion, both the increase of insulin resistance with age and its partial reversal by Ciglitazone treatment appear to modulate pancreatic amylase-gene expression in the obese Zucker rat.

scholarly journals Intestinal apolipoprotein A-IV gene expression in the piglet.

1990 ◽  
Vol 31 (3) ◽  
pp. 497-505
Author(s):  
D D Black ◽  
PL Rohwer-Nutter ◽  
NO Davidson
Keyword(s):  
Gene Expression ◽  
Apolipoprotein A

A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model

2017 ◽  
Vol 8 (3) ◽  
pp. 1293-1298 ◽  
Author(s):  
Andrea Bell ◽  
Soheila Korourian ◽  
Huawei Zeng ◽  
Joshua Phelps ◽  
Reza Hakkak
Keyword(s):  
Rat Model ◽  
Liver Steatosis ◽  
Zucker Rat ◽  
Obese Zucker Rat ◽  
Body Weights

Low daidzeinversushigh daidzein mean (±SD) body weights over 8 weeks.

Reduced triglyceride secretion: a metabolic consequence of chronic exercise.

1978 ◽  
Vol 234 (3) ◽  
pp. E221 ◽  
Author(s):  
C Simonelli ◽  
R P Eaton
Keyword(s):  
Exercise Training ◽  
Genetic Model ◽  
Secretion Rate ◽  
Lipid Lowering ◽  
Zucker Rat ◽  
Chronic Exercise ◽  
Similar Reduction ◽  
Triglyceride Secretion ◽  
Obese Zucker Rat

Chronic exercise training is recognized to reduce plasma lipid levels in man and animals, but the mechanism(s) mediating this phenomenon have not been defined. In the present study, we examined triglyceride (TG) production and disposal in vivo in a genetic model of human type IV hyperlipemia, the obese Zucker rat. Utilizing the normolipemic thin littermate as the control, we investigated endogenous production of TG utilizing the Triton methodology and peripheral disposal of an exogenous lipid emulsion utilizing Intralipid injection. In the sedentary state, the hyperlipemic obese Zucker rat demonstrated a threefold elevation in triglyceride secretion rate relative to the normolipemic thin littermate. After a 3-wk period of exercise training, a reduction of basal plasma TG concentration of 42% was associated with a 51% reduction in TG secretion rate, a change adequate to account for the hypolipemic response. Moreover, chronic exercise training also improved the ability to dispose of an Intralipid load. A similar reduction in TG production with reduced TG removal was observed in the thin normolipemic rats, a result that suggests that the lipid lowering response to exercise training may be predominantly mediated by reduced secretion of TG. The possible relationship between reduced TG secretion and alterations in the bihormonal axis of insulin and glucagon are discussed.

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