scholarly journals A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model

2019 ◽  
Vol 10 (10) ◽  
pp. 6851-6857 ◽  
Author(s):  
Eric Rochester ◽  
Brooke E. Wickman ◽  
Andrea Bell ◽  
Christy Simecka ◽  
Zachary S. Clayton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Density ◽  
Rat Model ◽  
Zucker Rat ◽  
Chemical Structures ◽  
Similar Chemical ◽  
Obese Zucker Rat ◽  
Osteogenic Gene Expression ◽  
Osteogenic Gene ◽  
Plant Compounds

Phytoestrogens are nonsteroidal plant compounds with similar chemical structures to mammalian estrogen capable of mimicking the effect of estrogen in selective tissues.

scholarly journals Correction: A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model

2019 ◽  
Vol 10 (12) ◽  
pp. 8309-8309
Author(s):  
Eric Rochester ◽  
Brooke E. Wickman ◽  
Andrea Bell ◽  
Christy Simecka ◽  
Zachary S. Clayton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Density ◽  
Rat Model ◽  
Zucker Rat ◽  
Obese Zucker Rat ◽  
Osteogenic Gene Expression ◽  
Osteogenic Gene

Correction for ‘A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model’ by Eric Rochester et al., Food Funct., 2019, 10, 6851–6857.

scholarly journals Effect of Pistachios and Mixed Nuts on Bone Density and Osteogenic Gene Expression in Young Male Rats

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Brooke E. Wickman ◽  
Eric Rochester ◽  
Laura Hauffe ◽  
Mark Kern ◽  
Mee Young Hong ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Density ◽  
Young Male ◽  
Male Rats ◽  
Osteogenic Gene Expression ◽  
Osteogenic Gene

A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model

2017 ◽  
Vol 8 (3) ◽  
pp. 1293-1298 ◽  
Author(s):  
Andrea Bell ◽  
Soheila Korourian ◽  
Huawei Zeng ◽  
Joshua Phelps ◽  
Reza Hakkak
Keyword(s):  
Rat Model ◽  
Liver Steatosis ◽  
Zucker Rat ◽  
Obese Zucker Rat ◽  
Body Weights

Low daidzeinversushigh daidzein mean (±SD) body weights over 8 weeks.

scholarly journals MicroRNA treatment modulates osteogenic differentiation potential of mesenchymal stem cells derived from human chorion and placenta

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kulisara Marupanthorn ◽  
Chairat Tantrawatpan ◽  
Pakpoom Kheolamai ◽  
Duangrat Tantikanlayaporn ◽  
Sirikul Manochantr
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Transcription Factor ◽  
Osteogenic Differentiation ◽  
Differentiation Potential ◽  
Osteogenic Gene Expression ◽  
Osteogenic Gene

AbstractMesenchymal stem cells (MSCs) are important in regenerative medicine because of their potential for multi-differentiation. Bone marrow, chorion and placenta have all been suggested as potential sources for clinical application. However, the osteogenic differentiation potential of MSCs derived from chorion or placenta is not very efficient. Bone morphogenetic protein-2 (BMP-2) plays an important role in bone development. Its effect on osteogenic augmentation has been addressed in several studies. Recent studies have also shown a relationship between miRNAs and osteogenesis. We hypothesized that miRNAs targeted to Runt-related transcription factor 2 (Runx-2), a major transcription factor of osteogenesis, are responsible for regulating the differentiation of MSCs into osteoblasts. This study examines the effect of BMP-2 on the osteogenic differentiation of MSCs isolated from chorion and placenta in comparison to bone marrow-derived MSCs and investigates the role of miRNAs in the osteogenic differentiation of MSCs from these sources. MSCs were isolated from human bone marrow, chorion and placenta. The osteogenic differentiation potential after BMP-2 treatment was examined using ALP staining, ALP activity assay, and osteogenic gene expression. Candidate miRNAs were selected and their expression levels during osteoblastic differentiation were examined using real-time RT-PCR. The role of these miRNAs in osteogenesis was investigated by transfection with specific miRNA inhibitors. The level of osteogenic differentiation was monitored after anti-miRNA treatment. MSCs isolated from chorion and placenta exhibited self-renewal capacity and multi-lineage differentiation potential similar to MSCs isolated from bone marrow. BMP-2 treated MSCs showed higher ALP levels and osteogenic gene expression compared to untreated MSCs. All investigated miRNAs (miR-31, miR-106a and miR148) were consistently downregulated during the process of osteogenic differentiation. After treatment with miRNA inhibitors, ALP activity and osteogenic gene expression increased over the time of osteogenic differentiation. BMP-2 has a positive effect on osteogenic differentiation of chorion- and placenta-derived MSCs. The inhibition of specific miRNAs enhanced the osteogenic differentiation capacity of various MSCs in culture and this strategy might be used to promote bone regeneration. However, further in vivo experiments are required to assess the validity of this approach.

Biomimetic fetal rotation bioreactor for engineering bone tissues—Effect of cyclic strains on upregulation of osteogenic gene expression

2018 ◽  
Vol 12 (4) ◽  
pp. e2039-e2050 ◽  
Author(s):  
Akhilandeshwari Ravichandran ◽  
Feng Wen ◽  
Jing Lim ◽  
Mark Seow Khoon Chong ◽  
Jerry K.Y. Chan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Osteogenic Gene Expression ◽  
Osteogenic Gene

Exogenous micro-RNA and antagomir modulate osteogenic gene expression in tenocytes

2019 ◽  
Vol 378 (2) ◽  
pp. 119-123
Author(s):  
Michelle Xiao ◽  
Kag C. Iglinski-Benjamin ◽  
Orr Sharpe ◽  
William H. Robinson ◽  
Geoffrey D. Abrams
Keyword(s):  
Gene Expression ◽  
Micro Rna ◽  
Osteogenic Gene Expression ◽  
Osteogenic Gene

scholarly journals Bone-specific overexpression of DMP1 influences osteogenic gene expression during endochondral and intramembranous ossification

2014 ◽  
Vol 55 (sup1) ◽  
pp. 121-124 ◽  
Author(s):  
Joshua D. Padovano ◽  
Amsaveni Ramachandran ◽  
Sara Bahmanyar ◽  
Sriram Ravindran ◽  
Anne George
Keyword(s):  
Gene Expression ◽  
Intramembranous Ossification ◽  
Osteogenic Gene Expression ◽  
Osteogenic Gene
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