scholarly journals Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium

2018 ◽  
Vol 59 (13) ◽  
pp. 5494 ◽  
Author(s):  
Liying Tang ◽  
Xue Wang ◽  
Jieli Wu ◽  
San Ming Li ◽  
Zhaoqiang Zhang ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Dry Eye ◽  
Corneal Epithelium

scholarly journals The immunoregulatory role of corneal epithelium-derived thrombospondin-1 in dry eye disease

2018 ◽  
Vol 16 (4) ◽  
pp. 470-477 ◽  
Author(s):  
Xuhua Tan ◽  
Yihe Chen ◽  
William Foulsham ◽  
Afsaneh Amouzegar ◽  
Takenori Inomata ◽  
...  
Keyword(s):  
Dry Eye ◽  
Corneal Epithelium ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Thrombospondin 1

scholarly journals Effects of Eye Drops Containing Hyaluronic Acid-Nimesulide Conjugates in a Benzalkonium Chloride-Induced Experimental Dry Eye Rabbit Model

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1366
Author(s):  
Tzu-Yang Chen ◽  
Ching-Li Tseng ◽  
Chih-An Lin ◽  
Hua-Yang Lin ◽  
Parthiban Venkatesan ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Dry Eye ◽  
Goblet Cell ◽  
Corneal Epithelium ◽  
Benzalkonium Chloride ◽  
Immunofluorescent Staining ◽  
Prolonged Treatment ◽  
Eye Drops ◽  
Cell Recovery ◽  
Anti Inflammatory

Dry eye syndrome (DES) is a common ocular disease worldwide. Currently, anti-inflammatory agents and immunosuppressive drugs, such as cyclosporine A, have been widely used to treat this chronic condition. However, the multifactorial etiology of DES, poor tolerance, low bioavailability, and prolonged treatment to response time have limited their usage. In this study, nimesulide, a cyclooxygenase (COX)-2 selective inhibitor, was conjugated with hyaluronic acid (HA), and the HA-nimesulide conjugates were expected to increase the solubility and biocompatibility for alleviating the DES in the benzalkonium chloride (BAC)-induced goblet cell-loss dry eye model. The therapeutic efficacy of HA-nimesulide was assessed using fluorescein staining, goblet cell density by conjunctival impression cytology, and histology and immunohistochemistry of corneal tissues. Compared to commercial artificial tears and Restasis®, the HA-nimesulide conjugates could promote goblet cell recovery and enhance the regeneration of the corneal epithelium. Importantly, immunofluorescent staining studies demonstrated that the HA-nimesulide conjugates could decrease the number of infiltrating CD11b-positive cells after two weeks of topical application. In the anti-inflammatory test, the HA-nimesulide conjugates could inhibit the production of pro-inflammatory cytokines and prostaglandin E2 (PGE2) in the lipopolysaccharide (LPS)-stimulated Raw 264.7 cell model. In conclusion, we demonstrated that HA-nimesulide conjugates had anti-inflammatory activity, and promoted goblet cell recovery and corneal epithelium regeneration when used as topical eye drops; accordingly, the HA-nimesulide conjugates could potentially be effective for the treatment of DES.

scholarly journals Sleep deprivation disrupts the lacrimal system and induces dry eye disease

2018 ◽  
Vol 50 (3) ◽  
pp. e451-e451 ◽  
Author(s):  
Sanming Li ◽  
Ke Ning ◽  
Jing Zhou ◽  
Yuli Guo ◽  
Houjian Zhang ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Lacrimal System

Protection of corneal epithelium by repetitive magnetic stimulation in a rabbit model of dry eye

2021 ◽  
Author(s):  
Ygal Rotenstreich ◽  
Adi Tzameret ◽  
Zehavit Goldberg ◽  
Ettel Bubis ◽  
Noa Avni-Zauberman ◽  
...  
Keyword(s):  
Dry Eye ◽  
Corneal Epithelium ◽  
Magnetic Stimulation ◽  
Rabbit Model ◽  
Repetitive Magnetic Stimulation

An In Vivo Confocal Masked Study on Corneal Epithelium and Subbasal Nerves in Patients with Dry Eye

2004 ◽  
Vol 45 (9) ◽  
pp. 3030 ◽  
Author(s):  
Jose´ M. Beni´tez del Castillo ◽  
Mohamed A. S. Wasfy ◽  
Cristina Fernandez ◽  
Julian Garcia-Sanchez
Keyword(s):  
Dry Eye ◽  
Corneal Epithelium

Influence of Benzalkonium Chloride on Langerhans Cells in Corneal Epithelium and Development of Dry Eye in Healthy Volunteers

2010 ◽  
Vol 35 (8) ◽  
pp. 762-769 ◽  
Author(s):  
Andrey Zhivov ◽  
Robert Kraak ◽  
Hartwig Bergter ◽  
Günther Kundt ◽  
Ria Beck ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Dry Eye ◽  
Corneal Epithelium ◽  
Langerhans Cells ◽  
Benzalkonium Chloride

Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye

2006 ◽  
Vol 83 (3) ◽  
pp. 526-535 ◽  
Author(s):  
Cintia S. De Paiva ◽  
Rosa M. Corrales ◽  
Arturo L. Villarreal ◽  
William J. Farley ◽  
De-Quan Li ◽  
...  
Keyword(s):  
Dry Eye ◽  
Corneal Epithelium ◽  
Inflammatory Cytokine ◽  
Cytokine Expression ◽  
Mapk Activation

scholarly journals N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation–Induced Dry Eye Syndrome

2020 ◽  
Vol 10 ◽  
Author(s):  
Qi Chen ◽  
Chunyan Ji ◽  
Ruihe Zheng ◽  
Longhe Yang ◽  
Jie Ren ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Dry Eye ◽  
Dry Eye Syndrome ◽  
Lipid Homeostasis
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